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Information on EC 1.13.12.17 - dichloroarcyriaflavin A synthase

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IUBMB Comments
The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold . Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A . The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine .
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The expected taxonomic range for this enzyme is: Streptomyces
Synonyms
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+ = dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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