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Literature summary for 1.13.12.17 extracted from

  • Howard-Jones, A.R.; Walsh, C.T.
    Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin (2007), J. Am. Chem. Soc., 129, 11016-11007.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+ Streptomyces longisporoflavus
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dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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?

Organism

Organism UniProt Comment Textmining
Streptomyces longisporoflavus Q06IS2
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
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Streptomyces longisporoflavus dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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?
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+ StaP/RebP is simply responsible for the two-electron intramolecular aryl-aryl coupling of dichlorochromopyrrolate to give the six-ring intermediate 5,7-dicarboxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole with all subsequent steps occurring nonenzymatically in solution. The study on the nonenzymatic steps following StaP-mediated aryl-aryl bond formation corroborates the proposed role of RebC (and by extension StaC) in intercepting and redirecting intermediates en route to the aglycones, K252c, 7-hydroxy-K252c, and arcyriaflavin A Streptomyces longisporoflavus dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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?

Synonyms

Synonyms Comment Organism
StaP
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Streptomyces longisporoflavus