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EC 4.3.1.25 Details
show Brenda entryEC number
4.3.1.25
Accepted name
phenylalanine/tyrosine ammonia-lyase
Reaction
(1) L-phenylalanine = trans-cinnamate + NH3;;
(2) L-tyrosine = trans-p-hydroxycinnamate + NH3
Other name(s)
PTAL,
bifunctional PAL
Systematic name
L-phenylalanine(or L-tyrosine):trans-cinnamate(or trans-p-hydroxycinnamate) ammonia-lyase
Comment
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.24 (phenylalanine ammonia-lyase). The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [4].
History
created 2008 (EC 4.3.1.5 created 1965, part-incorporated 2008)
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1 Oxidoreductases
2 Transferases
4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003
