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EC 4.3.1.18 Details

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EC number

4.3.1.18

Accepted name

D-serine ammonia-lyase

Reaction

D-serine = pyruvate + NH₃ (overall reaction);;(1a) D-serine = 2-aminoprop-2-enoate + H₂O;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H₂O = pyruvate + NH₃ (spontaneous)

Other name(s)

D-hydroxyaminoacid dehydratase, D-serine dehydrase, D-hydroxy amino acid dehydratase, D-serine hydrolase, D-serine dehydratase (deaminating), D-serine deaminase, D-serine hydro-lyase (deaminating)

Systematic name

D-serine ammonia-lyase (pyruvate-forming)

CAS registry number

9015-88-7

Comment

A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme’s original classification as EC 4.2.1.14, D-serine dehydratase) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also acts, slowly, on D-threonine.

History

created 1961 as EC 4.2.1.14, transferred 2001 to EC 4.3.1.18

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

3 Hydrolases

4 Lyases

4.1 Carbon-carbon lyases

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.1 aspartate ammonia-lyase

4.3.1.2 methylaspartate ammonia-lyase

4.3.1.3 histidine ammonia-lyase

4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase

4.3.1.5 phenylalanine ammonia-lyase

4.3.1.6 β-alanyl-CoA ammonia-lyase

4.3.1.7 ethanolamine ammonia-lyase

4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003

4.3.1.9 glucosaminate ammonia-lyase

4.3.1.10 serine-sulfate ammonia-lyase

4.3.1.11 dihydroxyphenylalanine ammonia-lyase

4.3.1.12 ornithine cyclodeaminase

4.3.1.13 carbamoyl-serine ammonia-lyase

4.3.1.14 3-aminobutyryl-CoA ammonia-lyase

4.3.1.15 diaminopropionate ammonia-lyase

4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.17 L-serine ammonia-lyase

4.3.1.18 D-serine ammonia-lyase

4.3.1.19 threonine ammonia-lyase

4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, deleted 2004

4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase

4.3.1.23 tyrosine ammonia-lyase

4.3.1.24 phenylalanine ammonia-lyase

4.3.1.25 phenylalanine/tyrosine ammonia-lyase

4.3.1.26 chromopyrrolate synthase

4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase

4.3.1.28 L-lysine cyclodeaminase

4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase

4.3.1.30 dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

4.3.1.31 L-tryptophan ammonia lyase

4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

4.3.2 Amidine-lyases

4.3.3 Amine-lyases

4.3.99 Other carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases