Reference on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate
Biochem. J.
229
127-133
1985
Gallus gallus
Kivirikko, K.I.; Myllylä, R.
The hydroxylation of prolyl and lysyl residues
Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York
1
53-104
1980
Gallus gallus
-
Kivirikko, K.I.; Myllylä, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Gallus gallus, Homo sapiens
Puistola, U.
Catalytic properties of lysyl hydroxylase from cells synthesizing genetically different collagen types
Biochem. J.
201
215-219
1982
BRENDA: Gallus gallus, Homo sapiens
Textmining: Sterna
Royce, P.M.; Barnes, M.J.
Failure of highly purified lysyl hydroxylase to hydroxylate lysyl residues in the non-helical regions of collagen
Biochem. J.
230
475-480
1985
Gallus gallus
Puistola, U.; Turpeenniemi-Hujanen, T.M.; Myllylä, R.; Kivirikko, K.I.
Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects
Biochim. Biophys. Acta
611
40-50
1980
Gallus gallus
Puistola, U.; Turpeenniemi-Hujanen, T.M.; Myllylä, R.; Kivirikko, K.I.
Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism
Biochim. Biophys. Acta
611
51-60
1980
Gallus gallus
Turpeenniemi-Hujanen, T.M.; Puistola, U.; Kivirikko, K.I.
Isolation of lysyl hydroxylase, an enzyme of collagen synthesis, from chick embryos as a homogeneous protein
Biochem. J.
189
247-253
1980
Gallus gallus
Miller, R.L.; Varner, H.H.
Purification and enzymatic properties of lysyl hydroxylase from fetal procine skin
Biochemistry
18
5928-5932
1979
Sus scrofa
-
Murray, J.C.; Cassell, R.H.; Pinnell, S.R.
Inhibition of lysyl hydroxylase by catechol analogs
Biochim. Biophys. Acta
481
63-70
1977
BRENDA: Gallus gallus
Textmining: Transformation, Dialysis
Ryhänen, L.
Lysyl hydroxylase. Further purification and characterization of the enzyme from chick embryos and chick embryo cartilage
Biochim. Biophys. Acta
438
71-89
1976
Gallus gallus
Kivirikko, K.I.; Shudo, K.; Sakakibara, S.; Prockop, D.J.
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of alpha-ketoglutarate
Biochemistry
11
122-129
1972
Gallus gallus
Popenoe, E.A.; Aronson, R.B.
Partial purification and properties of collagen lysine hydroxylase from chick embryos
Biochim. Biophys. Acta
258
380-386
1972
Gallus gallus
Kivirikko, K.I.; Prockop, D.J.
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos
Biochim. Biophys. Acta
258
366-379
1972
Gallus gallus
Hausmann E.
Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen
Biochim. Biophys. Acta
133
591-593
1967
Gallus gallus
Kellokumpu, S.; Sormunen, R.; Heikkinen, J.; Myllyla, R.
Lysyl hydroxylase, a collagen processing enzyme, exemplifies a novel class of luminally-oriented peripheral membrane proteins in the endoplasmic reticulum
J. Biol. Chem.
269
30524-30529
1994
Homo sapiens
Valtavaara, M.; Papponen, H.; Pirttilae, A.M.; Hiltunen, K.; Helander, H.; Myllylae, R.
Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle
J. Biol. Chem.
272
6831-6834
1997
Homo sapiens (O00469), Homo sapiens
Passoja, K.; Rautavuoma, K.; Ala-Kokko, L.; Kosonen, T.; Kivirikko, K.I.
Cloning and characterization of a third human lysyl hydroxylase isoform
Proc. Natl. Acad. Sci. USA
95
10482-10486
1998
BRENDA: Homo sapiens (O60568), Homo sapiens
Textmining: Caenorhabditis elegans
Rautavuoma, K.; Takaluoma, K.; Passoja, K.; Pirskanen, A.; Kvist, A.P.; Kivirikko, K.I.; Myllyharju, J.
Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3: The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
J. Biol. Chem.
277
23084-23091
2002
Homo sapiens
Wang, C.; Risteli, M.; Heikkinen, J.; Hussa, A.K.; Uitto, L.; Myllyla, R.
Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3)
J. Biol. Chem.
277
18568-18573
2002
BRENDA: Caenorhabditis elegans
Textmining: Nematoda, Homo sapiens
Samimi, A.; Last, J.A.
Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon
Toxicol. Appl. Pharmacol.
176
181-186
2001
Rattus norvegicus (Q63321)
Armstrong, L.C.; Last, J.A.
Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system
Biochim. Biophys. Acta
1264
93-102
1995
BRENDA: Gallus gallus, Homo sapiens, Rattus norvegicus (Q63321)
Textmining: Rattus
Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Mohr, J.; Kivirikko, K.I.
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism
Biochem. J.
242
163-169
1987
Homo sapiens
Wang, C.; Luosujärvi, H.; Heikkinen, J.; Risteli, M.; Uitto, L.; Myllylä, R.
The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro
Matrix Biol.
21
559-566
2002
Homo sapiens
Ruotsalainen, H.; Vanhatupa, S.; Tampio, M.; Sipilä, L.; Valtavaara, M.; Myllylä, R.
Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase
Matrix Biol.
20
137-146
2001
Mus musculus, Mus musculus (Q9R0E1)
Mercer, D.K.; Nicol, P.F.; Kimbembe, C.; Robins, S.P.
Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms
Biochem. Biophys. Res. Commun.
307
803-809
2003
BRENDA: Rattus norvegicus, Rattus norvegicus (Q811A3)
Textmining: Rattus
Suokas, M.; Lampela, O.; Juffer, A.H.; Myllyla, R.; Kellokumpu, S.
Retrieval-independent localization of lysyl hydroxylase in the endoplasmic reticulum via a peptide fold in its iron-binding domain
Biochem. J.
370
913-920
2003
Homo sapiens
van der Slot, A.J.; Zuurmond, A.M.; Bardoel, A.F.; Wijmenga, C.; Pruijs, H.E.; Sillence, D.O.; Brinckmann, J.; Abraham, D.J.; Black, C.M.; Verzijl, N.; DeGroot, J.; Hanemaaijer, R.; TeKoppele, J.M.; Huizinga, T.W.; Bank, R.A.
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis
J. Biol. Chem.
278
40967-40972
2003
Homo sapiens (O00469), Homo sapiens
Risteli, M.; Niemitalo, O.; Lankinen, H.; Juffer, A.H.; Myllyla, R.
Characterization of collagenous peptides bound to lysyl hydroxylase isoforms
J. Biol. Chem.
279
37535-37543
2004
BRENDA: Caenorhabditis elegans, Homo sapiens
Textmining: Mus musculus, Rattus, vertebrata
Pornprasertsuk, S.; Duarte, W.R.; Mochida, Y.; Yamauchi, M.
Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells
J. Bone Miner. Res.
19
1349-1355
2004
Mus musculus
Walker, L.C.; Overstreet, M.A.; Siddiqui, A.; De Paepe, A.; Ceylaner, G.; Malfait, F.; Symoens, S.; Atsawasuwan, P.; Yamauchi, M.; Ceylaner, S.; Bank, R.A.; Yeowell, H.N.
A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an Ehlers-Danlos VIA patient
J. Invest. Dermatol.
124
914-918
2005
Homo sapiens
Walker, L.C.; Overstreet, M.A.; Yeowell, H.N.
Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts
Matrix Biol.
23
515-523
2005
Homo sapiens (O00469), Homo sapiens
Wu, J.; Reinhardt, D.P.; Batmunkh, C.; Lindenmaier, W.; Far, R.K.; Notbohm, H.; Hunzelmann, N.; Brinckmann, J.
Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts
Exp. Cell Res.
312
3485-3494
2006
Homo sapiens
Pornprasertsuk, S.; Duarte, W.R.; Mochida, Y.; Yamauchi, M.
Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization
J. Bone Miner. Res.
20
81-87
2005
BRENDA: Mus musculus
Textmining: Mus sp., Electron
Ruotsalainen, H.; Sipilae, L.; Vapola, M.; Sormunen, R.; Salo, A.M.; Uitto, L.; Mercer, D.K.; Robins, S.P.; Risteli, M.; Aszodi, A.; Faessler, R.; Myllylae, R.
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes
J. Cell Sci.
119
625-635
2006
BRENDA: Mus musculus
Textmining: Mus sp.
Salo, A.M.; Wang, C.; Sipilae, L.; Sormunen, R.; Vapola, M.; Kervinen, P.; Ruotsalainen, H.; Heikkinen, J.; Myllylae, R.
Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling
J. Cell. Physiol.
207
644-653
2006
Mus musculus
Zuurmond, A.M.; van der Slot-Verhoeven, A.J.; van Dura, E.A.; De Groot, J.; Bank, R.A.
Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis
Matrix Biol.
24
261-270
2005
Homo sapiens
Salo, A.M.; Sipilae, L.; Sormunen, R.; Ruotsalainen, H.; Vainio, S.; Myllylae, R.
The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult
Matrix Biol.
25
475-483
2006
Mus musculus
Schneider, V.A.; Granato, M.
Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2
Matrix Biol.
26
12-19
2007
BRENDA: Danio rerio (A0JMD1), Danio rerio (A4U7F8), Danio rerio (A4U7F9), Danio rerio
Textmining: vertebrata, Homo sapiens, animal
Takaluoma, K.; Lantto, J.; Myllyharju, J.
Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences
Matrix Biol.
26
396-403
2007
BRENDA: Homo sapiens
Textmining: vertebrata
Takaluoma, K.; Hyry, M.; Lantto, J.; Sormunen, R.; Bank, R.A.; Kivirikko, K.I.; Myllyharju, J.; Soininen, R.
Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice
J. Biol. Chem.
282
6588-6596
2007
BRENDA: Mus musculus (Q9R0E2)
Textmining: Mus sp., Homo sapiens
Salo, A.M.; Cox, H.; Farndon, P.; Moss, C.; Grindulis, H.; Risteli, M.; Robins, S.P.; Myllylae, R.
A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene
Am. J. Hum. Genet.
83
495-503
2008
BRENDA: Homo sapiens, Homo sapiens (O60568)
Textmining: animal
Nagaoka, H.; Mochida, Y.; Atsawasuwan, P.; Kaku, M.; Kondoh, T.; Yamauchi, M.
1,25(OH)2D3 regulates collagen quality in an osteoblastic cell culture system
Biochem. Biophys. Res. Commun.
377
674-678
2008
Mus musculus
Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco
Biomacromolecules
10
2640-2645
2009
BRENDA: Homo sapiens
Textmining: Nicotiana tabacum, animal
Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
J. Biol. Chem.
284
28204-28211
2009
BRENDA: Homo sapiens, Homo sapiens (O60568)
Textmining: Mus musculus, Mus sp.
Hyry, M.; Lantto, J.; Myllyharju, J.
Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2
J. Biol. Chem.
284
30917-30924
2009
Homo sapiens
Wang, C.; Kovanen, V.; Raudasoja, P.; Eskelinen, S.; Pospiech, H.; Myllylae, R.
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
J. Cell. Mol. Med.
13
508-521
2009
Homo sapiens (O60568)
Yeowell, H.N.; Walker, L.C.; Mauger, D.M.; Seth, P.; Garcia-Blanco, M.A.
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2
J. Invest. Dermatol.
129
1402-1411
2009
BRENDA: Homo sapiens
Textmining: Mus sp., Scleroderma
Webby, C.J.; Wolf, A.; Gromak, N.; Dreger, M.; Kramer, H.; Kessler, B.; Nielsen, M.L.; Schmitz, C.; Butler, D.S.; Yates, J.R.; Delahunty, C.M.; Hahn, P.; Lengeling, A.; Mann, M.; Proudfoot, N.J.; Schofield, C.J.; Boettger, A.
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
Science
325
90-93
2009
Homo sapiens
Mantri, M.; Krojer, T.; Bagg, E.A.; Webby, C.J.; Butler, D.S.; Kochan, G.; Kavanagh, K.L.; Oppermann, U.; McDonough, M.A.; Schofield, C.J.
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
J. Mol. Biol.
401
211-222
2010
BRENDA: Homo sapiens (Q6NYC1)
Textmining: animal, plant
Liefhebber, J.; Punt, S.; Spaan, W.; van Leeuwen, H.
The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein
BMC Cell Biol.
11
33
2010
Homo sapiens, Homo sapiens (Q8NBJ5)
Wang, C.; Ristiluoma, M.M.; Salo, A.M.; Eskelinen, S.; Myllylae, R.
Lysyl hydroxylase 3 is secreted from cells by two pathways
J. Cell. Physiol.
227
668-675
2012
Canis lupus familiaris, Homo sapiens (O60568), Canis lupus familiaris Madin-Darby
Remst, D.F.; Blaney Davidson, E.N.; Vitters, E.L.; Bank, R.A.; van den Berg, W.B.; van der Kraan, P.M.
TGF-beta induces lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling
Cell Tissue Res.
355
163-171
2013
BRENDA: Homo sapiens
Textmining: Mus musculus
Tsukamoto, H.; Yokoyama, Y.; Suzuki, T.; Mizuta, S.; Yoshinaka, R.; Akahane, Y.
Cloning and expression of cDNA encoding lysyl hydroxylase 1, 2 and 3 in tiger puffer Takifugu rubripes
Comp. Biochem. Physiol. B
166
123-132
2013
Takifugu rubripes (A5A6S1), Takifugu rubripes (A5A6S2), Takifugu rubripes (A5A6S3), Takifugu rubripes
Bunt, S.; Denholm, B.; Skaer, H.
Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod
Gene Expr. Patterns
11
72-78
2011
BRENDA: Drosophila melanogaster
Textmining: Drosophila, Phyla, animal
Luther, K.B.; Huelsmeier, A.J.; Schegg, B.; Deuber, S.A.; Raoult, D.; Hennet, T.
Mimivirus collagen is modified by bifunctional lysyl hydroxylase and glycosyltransferase enzyme
J. Biol. Chem.
286
43701-43709
2011
BRENDA: Acanthamoeba polyphaga Mimivirus, Acanthamoeba polyphaga Mimivirus L230
Textmining: Mimivirus, Bacteria, Fungi, Porifera, Homo sapiens, Viruses, Metazoa, Polyphaga
Sricholpech, M.; Perdivara, I.; Nagaoka, H.; Yokoyama, M.; Tomer, K.B.; Yamauchi, M.
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture
J. Biol. Chem.
286
8846-8856
2011
Mus musculus (Q9R0E1), Mus musculus, Mus musculus CRL-2593 (Q9R0E1)
Heikkinen, J.; Risteli, M.; Lampela, O.; Alavesa, P.; Karppinen, M.; Juffer, A.; Myllylae, R.
Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547
Matrix Biol.
30
27-33
2011
BRENDA: Homo sapiens
Textmining: Mus musculus
Mantri, M.; Webby, C.; Loik, N.; Hamed, R.; Nielsen, M.; McDonough, M.; McCullagh, J.; Boettger, A.; Schofield, C.; Wolf, A.
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
MedChemComm
3
80-85
2012
Homo sapiens
-
Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Mol. Cancer Res.
11
456-466
2013
Homo sapiens
Ruotsalainen, H.; Risteli, M.; Wang, C.; Wang, Y.; Karppinen, M.; Bergmann, U.; Kvist, A.P.; Pospiech, H.; Herzig, K.H.; Myllylae, R.
The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin
PLoS ONE
7
e50045
2012
BRENDA: Mus musculus, Mus musculus C57BL/6
Textmining: Mus sp., Homo sapiens
Watt, S.A.; Dayal, J.H.; Wright, S.; Riddle, M.; Pourreyron, C.; McMillan, J.R.; Kimble, R.M.; Prisco, M.; Gartner, U.; Warbrick, E.; McLean, W.H.; Leigh, I.M.; McGrath, J.A.; Salas-Alanis, J.C.; Tolar, J.; South, A.P.
Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa
PLoS ONE
10
e0137639
2015
Homo sapiens
Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin
PLoS ONE
9
e113498
2014
Mus sp., Mus musculus, Rattus
Guo, H.F.; Cho, E.J.; Devkota, A.K.; Chen, Y.; Russell, W.; Phillips, G.N.; Yamauchi, M.; Dalby, K.N.; Kurie, J.M.
A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay
Arch. Biochem. Biophys.
618
45-51
2017
Homo sapiens (O00469), Homo sapiens
Dayer, C.; Stamenkovic, I.
Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation
J. Biol. Chem.
290
13763-13778
2015
Homo sapiens (O60568)
Gjaltema, R.A.; de Rond, S.; Rots, M.G.; Bank, R.A.
Procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor beta-1 activation mechanism
J. Biol. Chem.
290
28465-28476
2015
Homo sapiens (O00469)
Kogan, N.M.; Melamed, E.; Wasserman, E.; Raphael, B.; Breuer, A.; Stok, K.S.; Sondergaard, R.; Escudero, A.V.; Baraghithy, S.; Attar-Namdar, M.; Friedlander-Barenboim, S.; Mathavan, N.; Isaksson, H.; Mechoulam, R.; Mueller, R.; Bajayo, A.; Gabet, Y.; Bab, I.
Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts
J. Bone Miner. Res.
30
1905-1913
2015
BRENDA: Rattus norvegicus (Q5U367), Rattus norvegicus (Q63321), Rattus norvegicus (Q811A3)
Textmining: Cannabis, Rattus
Chen, Y.; Terajima, M.; Yang, Y.; Sun, L.; Ahn, Y.H.; Pankova, D.; Puperi, D.S.; Watanabe, T.; Kim, M.P.; Blackmon, S.H.; Rodriguez, J.; Liu, H.; Behrens, C.; Wistuba, I.I.; Minelli, R.; Scott, K.L.; Sanchez-Adams, J.; Guilak, F.; Pati, D.; Thilaganathan, N.; Burns, A.R.; Creighton, C.J.; Martinez, E.D.; Zal, T.; Allen, K.; Yamauchi, M.; Kurie, J.M.
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
J. Clin. Invest.
125
1147-1162
2015
Homo sapiens (O00469), Homo sapiens, Mus musculus (Q9R0B9), Mus musculus
Zhang, L.; Li, M.M.; Corcoran, M.; Zhang, S.; Cooper, G.J.
Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin
Mol. Cell. Endocrinol.
399
164-177
2015
Mus musculus (Q9R0B9), Mus musculus (Q9R0E1), Mus musculus (Q9R0E2)
Heard, M.E.; Besio, R.; Weis, M.; Rai, J.; Hudson, D.M.; Dimori, M.; Zimmerman, S.M.; Kamykowski, J.A.; Hogue, W.R.; Swain, F.L.; Burdine, M.S.; Mackintosh, S.G.; Tackett, A.J.; Suva, L.J.; Eyre, D.R.; Morello, R.
Sc65-null mice provide evidence for a novel endoplasmic reticulum complex regulating collagen lysyl hydroxylation
PLoS Genet.
12
e1006002
2016
BRENDA: Mus musculus (Q9R0E2), Mus musculus, Mus musculus 714 (Q9R0E2)
Textmining: Mus sp.
Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin
PLoS ONE
9
e113498
2014
BRENDA: Mus musculus (Q9R0E1), Mus musculus, Mus musculus C57BL/6 (Q9R0E1)
Textmining: Mus sp., Rattus
Chen, Y.; Terajima, M.; Banerjee, P.; Guo, H.; Liu, X.; Yu, J.; Yamauchi, M.; Kurie, J.M.
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch
Sci. Rep.
7
46021
2017
Mus musculus (Q9R0B9), Mus musculus
Neyazi, B.; Tanrikulu, L.; Wilkens, L.; Hartmann, C.; Stein, K.P.; Dumitru, C.A.; Sandalcioglu, I.E.
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size
World Neurosurg.
102
79-84
2017
Homo sapiens (O00469), Homo sapiens
Scietti, L.; Chiapparino, A.; De Giorgi, F.; Fumagalli, M.; Khoriauli, L.; Nergadze, S.; Basu, S.; Olieric, V.; Cucca, L.; Banushi, B.; Profumo, A.; Giulotto, E.; Gissen, P.; Forneris, F.
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Nat. Commun.
9
3163
2018
BRENDA: Homo sapiens (O60568), Homo sapiens
Textmining: Ursidae
Piersma, B.; Bank, R.A.
Collagen cross-linking mediated by lysyl hydroxylase 2 an enzymatic battlefield to combat fibrosis
Essays Biochem.
63
377-387
2019
Homo sapiens (O00469)
Gong, S.; Wu, C.; Koehler, F.; Meixensberger, J.; Schopow, N.; Kallendrusch, S.
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase family novel prognostic biomarkers and tumor microenvironment regulators for lower-grade glioma
Front. Cell. Neurosci.
16
838548
2022
Homo sapiens (O00469), Homo sapiens (O60568), Homo sapiens (Q02809)
Xu, Y.; Zhang, L.; Wei, Y.; Zhang, X.; Xu, R.; Han, M.; Huang, B.; Chen, A.; Li, W.; Zhang, Q.; Li, G.; Wang, J.; Zhao, P.; Li, X.
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion
Oncotarget
8
23401-23413
2017
Homo sapiens (O00469), Homo sapiens
Handa, JT; Murad, S; Jaffe, GJ
Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil.
Invest Ophthalmol Vis Sci
35
463-9
1994
Homo sapiens
Zhou, P; Liu, Y; Lv, F; Nie, M; Jiang, Y; Wang, O; Xia, W; Xing, X; Li, M
Novel mutations in FKBP10 and PLOD2 cause rare Bruck syndrome in Chinese patients.
PLoS One
9
e107594
2014
Homo sapiens
Siegel, RC; Chen, KH; Greenspan, JS; Aguiar, JM
Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat.
Proc Natl Acad Sci U S A
75
2945-9
1978
Septa, Rattus
Ganesan, M; Tikhanovich, I; Vangimalla, SS; Dagur, RS; Wang, W; Poluektova, LI; Sun, Y; Mercer, DF; Tuma, D; Weinman, SA; Kharbanda, KK; Osna, NA
Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism.
Cell Mol Gastroenterol Hepatol
5
101-112
2018
Hepacivirus C
Risteli, J; Kivirikko, KI
Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities.
Biochem J
158
361-7
1976
Rattus
Risteli, J; Kivirikko, KI
Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury.
Biochem J
144
115-22
1974
Rattus
Miller, RL; Varner, HH
Purification and enzymatic properties of lysyl hydroxylase from fetal porcine skin.
Biochemistry
18
5828-32
1979
Sus scrofa, Bos taurus
Oppenheim, B; Englard, S
Inhibition by collagen chains of lysyl hydroxylase of chick embryo and of WI-38 human lung fibroblasts.
Biochem Biophys Res Commun
70
248-57
1976
Homo sapiens
Elsas, LJ; Miller, RL; Pinnell, SR
Inherited human collagen lysyl hydroxylase deficiency: ascorbic acid response.
J Pediatr
92
378-84
1978
Homo sapiens
Hautala, T; Heikkinen, J; Kivirikko, KI; Myllylä, R
Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts.
Biochem J
283 ( Pt 1)
51-4
1992
Homo sapiens
Yeowell, HN; Ha, V; Walker, LC; Murad, S; Pinnell, SR
Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine.
J Invest Dermatol
99
864-9
1992
Homo sapiens
Hautala, T; Byers, MG; Eddy, RL; Shows, TB; Kivirikko, KI; Myllylä, R
Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2.
Genomics
13
62-9
1992
Homo sapiens
Murad, S; Sivarajah, A; Pinnell, SR
Serum stimulation of lysyl hydroxylase activity in cultured human skin fibroblasts.
Connect Tissue Res
13
181-6
1985
Homo sapiens
Murad, S; Tajima, S; Pinnell, SR
A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts.
Arch Biochem Biophys
241
356-63
1985
Homo sapiens, Chelator
Ramamurthy, NS; Greenwald, RA; Schneir, M; Golub, LM
The effect of alloxan diabetes on prolyl and lysyl hydroxylase activity in uninflamed and inflamed rat gingiva.
Arch Oral Biol
30
679-83
1985
Rattus
Myllylä, R; Pajunen, L; Kivirikko, KI
Polyclonal and monoclonal antibodies to human lysyl hydroxylase and studies on the molecular heterogeneity of the enzyme.
Biochem J
253
489-96
1988
Homo sapiens, Mus musculus, Staphylococcus aureus V8
Glass, DB; Dembure, PP; Priest, JH; Elsas, LJ
A [3H]lysine-containing synthetic peptide substrate for human protocollagen lysyl hydroxylase.
Biochim Biophys Acta
840
143-52
1985
Homo sapiens
Anttinen, H; Orava, S; Ryhänen, L; Kivirikko, KI
Assay of protocollagen lysyl hydroxylase activity in the skin of human subjects and changes in the activity with age.
Clin Chim Acta
47
289-94
1973
Homo sapiens
Murad, S; Sivarajah, A; Pinnell, SR
Prolyl and lysyl hydroxylase activities of human skin fibroblasts: effect of donor age and ascorbate.
J Invest Dermatol
75
404-7
1980
Homo sapiens
Murad, S; Sivarajah, A; Pinnell, SR
Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid.
Biochem Biophys Res Commun
101
868-75
1981
Homo sapiens
Turpeenniemi-Hujanen, TM; Puistola, U; Kivirikko, KI
Human lysyl hydroxylase: purification to homogeneity, partial characterization and comparison of catalytic properties with those of a mutant enzyme from Ehlers-Danlos syndrome type VI fibroblasts.
Coll Relat Res
1
355-66
1981
Homo sapiens
Yeowell, HN; Walker, LC; Marshall, MK; Murad, S; Pinnell, SR
The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI.
Arch Biochem Biophys
321
510-6
1995
Homo sapiens
Saika, S; Ooshima, A; Hashizume, N; Yamanaka, O; Tanaka, S; Okada, Y; Kobata, S
Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts.
Graefes Arch Clin Exp Ophthalmol
233
347-53
1995
Oryctolagus cuniculus, Areas
Heikkinen, J; Hautala, T; Kivirikko, KI; Myllylä, R
Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients.
Genomics
24
464-71
1994
Homo sapiens
Yeowell, HN; Ha, V; Clark, WL; Marshall, MK; Pinnell, SR
Sequence analysis of a cDNA for lysyl hydroxylase isolated from human skin fibroblasts from a normal donor: differences from human placental lysyl hydroxylase cDNA.
J Invest Dermatol
102
382-4
1994
Homo sapiens
Krol, BJ; Murad, S; Walker, LC; Marshall, MK; Clark, WL; Pinnell, SR; Yeowell, HN
The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system.
J Invest Dermatol
106
11-6
1996
Homo sapiens
Pirskanen, A; Kaimio, AM; Myllylä, R; Kivirikko, KI
Site-directed mutagenesis of human lysyl hydroxylase expressed in insect cells. Identification of histidine residues and an aspartic acid residue critical for catalytic activity.
J Biol Chem
271
9398-402
1996
Homo sapiens
Seitzer, U; Bätge, B; Acil, Y; Müller, PK
Transforming growth factor beta 1 influences lysyl hydroxylation of collagen I and reduces steady-state levels of lysyl hydroxylase mRNA in human osteoblast-like cells.
Eur J Clin Invest
25
959-66
1995
Homo sapiens
Yeowell, HN; Walker, LC; Murad, S; Pinnell, SR
A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine.
Arch Biochem Biophys
347
126-31
1997
Homo sapiens
Passoja, K; Myllyharju, J; Pirskanen, A; Kivirikko, KI
Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1.
FEBS Lett
434
145-8
1998
Homo sapiens
Yeowell, HN; Walker, LC
Tissue specificity of a new splice form of the human lysyl hydroxylase 2 gene.
Matrix Biol
18
179-87
1999
Homo sapiens
Ruotsalainen, H; Sipilä, L; Kerkelä, E; Pospiech, H; Myllylä, R
Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse.
Matrix Biol
18
325-9
1999
Mus musculus
Uzawa, K; Grzesik, WJ; Nishiura, T; Kuznetsov, SA; Robey, PG; Brenner, DA; Yamauchi, M
Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro.
J Bone Miner Res
14
1272-80
1999
Homo sapiens
Rautavuoma, K; Passoja, K; Helaakoski, T; Kivirikko, KI
Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3).
Matrix Biol
19
73-9
2000
Homo sapiens
Yeowell, HN; Walker, LC; Farmer, B; Heikkinen, J; Myllyla, R
Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one family.
Hum Mutat
16
90
2000
Homo sapiens
Norman, KR; Moerman, DG
The let-268 locus of Caenorhabditis elegans encodes a procollagen lysyl hydroxylase that is essential for type IV collagen secretion.
Dev Biol
227
690-705
2000
Caenorhabditis elegans, Metazoa
Sipilä, L; Szatanik, M; Vainionpää, H; Ruotsalainen, H; Myllylä, R; Guénet, JL
The genes encoding mouse lysyl hydroxylase isoforms map to chromosomes 4,5, and 9.
Mamm Genome
11
1132-4
2000
Mus musculus
Rautavuoma, K; Takaluoma, K; Sormunen, R; Myllyharju, J; Kivirikko, KI; Soininen, R
Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.
Proc Natl Acad Sci U S A
101
14120-5
2004
Mus sp., Electron
Walker, LC; Teebi, AS; Marini, JC; De Paepe, A; Malfait, F; Atsawasuwan, P; Yamauchi, M; Yeowell, HN
Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
Mol Genet Metab
83
312-21
2004
Homo sapiens
Tasker, PN; Macdonald, H; Fraser, WD; Reid, DM; Ralston, SH; Albagha, OM
Association of PLOD1 polymorphisms with bone mineral density in a population-based study of women from the UK.
Osteoporos Int
2006
Homo sapiens
Tasker, PN; Macdonald, H; Fraser, WD; Reid, DM; Ralston, SH; Albagha, OM
Association of PLOD1 polymorphisms with bone mineral density in a population-based study of women from the UK.
Osteoporos Int
17
1078-85
2006
Homo sapiens
Giunta, C; Bürer-Chambaz, C; Steinmann, B
Novel human pathological mutations. Gene symbol: PLOD1. Disease: Ehlers-Danlos syndrome type VIA, kyphoscoliotic type.
Hum Genet
125
346
2009
Homo sapiens
Giunta, C; Bürer-Chambaz, C; Steinmann, B
Novel human pathological mutations. Gene symbol: PLOD1. Disease: Ehlers-Danlos syndrome type VIA, kyphoscoliotic type.
Hum Genet
125
346
2009
Homo sapiens
Surmon, L; Bobek, G; Chiu, CL; Makris, A; Lind, JM; Hennessy, A
PP001. Variability in MRNA expression of Jmjd6 and FLT-1 variants in normal and preeclamptic human placenta.
Pregnancy Hypertens
2
240
2012
Homo sapiens, collection
Aprelikova, O; Chen, K; El Touny, LH; Brignatz-Guittard, C; Han, J; Qiu, T; Yang, HH; Lee, MP; Zhu, M; Green, JE
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Clin Epigenetics
8
38
2016
Transformation, Homo sapiens, Mus musculus
Yanagihara, T; Tomino, T; Uruno, T; Fukui, Y
Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Biochem Biophys Res Commun
489
8-13
2017
Mus musculus, Rattus
van Dijk, FS; Mancini, GMS; Maugeri, A; Cobben, JM
Ehlers Danlos syndrome, kyphoscoliotic type due to Lysyl Hydroxylase 1 deficiency in two children without congenital or early onset kyphoscoliosis.
Eur J Med Genet
60
536-540
2017
Homo sapiens
Yanagihara, T; Tomino, T; Uruno, T; Fukui, Y
Corrigendum to "Thymic epithelial cell-specific deletion of Jmjd6 reduces aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes" [Biochemical and Biophysical Research Communications 489/1 (2017) 8-13].
Biochem Biophys Res Commun
491
1126
2017
Mus musculus
Wen, C; Xu, M; Mo, C; Cheng, Z; Guo, Q; Zhu, X
JMJD6 exerts function in neuropathic pain by regulating NF??B following peripheral nerve injury in rats.
Int J Mol Med
42
633-642
2018
Rattus
Mo, C; Xu, M; Wen, C; Chang, R; Huang, C; Zou, W; Zhu, X; Guo, Q
Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury.
Front Neurosci
12
542
2018
Rattus
Baek, JH; Yun, HS; Kwon, GT; Lee, J; Kim, JY; Jo, Y; Cho, JM; Lee, CW; Song, JY; Ahn, J; Kim, JS; Kim, EH; Hwang, SG
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Cell Death Dis
10
156
2019
Homo sapiens, Mus musculus
Kasamatsu, A; Uzawa, K; Hayashi, F; Kita, A; Okubo, Y; Saito, T; Kimura, Y; Miyamoto, I; Oka, N; Shiiba, M; Ito, C; Toshimori, K; Miki, T; Yamauchi, M; Tanzawa, H
Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
Biochem Biophys Res Commun
512
486-491
2019
Mus sp.
Xu, WH; Xu, Y; Wang, J; Tian, X; Wu, J; Wan, FN; Wang, HK; Qu, YY; Zhang, HL; Ye, DW
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.
Aging (Albany NY)
11
6503-6521
2019
Homo sapiens
Lee, S; Liu, H; Hill, R; Chen, C; Hong, X; Crawford, F; Kingsley, M; Zhang, Q; Liu, X; Chen, Z; Lengeling, A; Bernt, KM; Marrack, P; Kappler, J; Zhou, Q; Li, CY; Xue, Y; Hansen, K; Zhang, G
JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes.
Elife
9
2020
eukaryota
Lee, G; Hwang, JH; Kim, A; Park, JH; Lee, MJ; Kim, B; Kim, SM
Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors.
Viruses
12
2020
Foot-and-mouth disease virus
Cangiano, M; Grudniewska, M; Salji, MJ; Nykter, M; Jenster, G; Urbanucci, A; Granchi, Z; Janssen, B; Hamilton, G; Leung, HY; Beumer, IJ
Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer.
Cancers (Basel)
13
2021
Homo sapiens
Shire, K; Marcon, E; Greenblatt, J; Frappier, L
Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.
Virology
562
103-109
2021
Human gammaherpesvirus 4
Cohen, MP; Khalifa, A
Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
Biochim Biophys Acta
496
88-94
1977
Rattus, Metazoa
Lawrence, P; Conderino, JS; Rieder, E
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: Role of Jumonji C-domain containing protein 6 in RHA demethylation.
Virology
452-453
1-11
2014
Foot-and-mouth disease virus, picornaviridae
Liao, W; Bao, Z; Cheng, C; Mok, YK; Wong, WS
Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts.
Proteomics
8
2640-50
2008
Homo sapiens
Lawrence, P; Rai, D; Conderino, JS; Uddowla, S; Rieder, E
Role of Jumonji C-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus.
Virology
492
38-52
2016
Foot-and-mouth disease virus
Schwanekamp, JA; Lorts, A; Vagnozzi, RJ; Vanhoutte, D; Molkentin, JD
Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling.
Arterioscler Thromb Vasc Biol
36
60-8
2016
Mus sp.
Boonsongserm, P; Angsuwatcharakon, P; Puttipanyalears, C; Aporntewan, C; Kongruttanachok, N; Aksornkitti, V; Kitkumthorn, N; Mutirangura, A
Tumor-induced DNA methylation in the white blood cells of patients with colorectal cancer.
Oncol Lett
18
3039-3048
2019
Homo sapiens
Sun, Y; Liu, Y; Sun, X; Lin, Y; Yin, D; Xu, S; Yang, G
Insights into body size variation in cetaceans from the evolution of body-size-related genes.
BMC Evol Biol
19
157
2019
Cetacea
Oh, JE; Krapfenbauer, K; Lubec, G
Proteomic identification of collagens and related proteins in human fibroblasts.
Amino Acids
27
305-11
2004
Homo sapiens
Gistelinck, C; Eckhard Witten, P; Huysseune, A; Symoens, S; Malfait, F; Larionova, D; Simoens, P; Dierick, M; Van Hoorebeke, L; De Paepe, A; Kwon, RY; Weis, M; Eyre, DR; Willaert, A; Coucke, PJ
Loss of Type I Collagen Telopeptide Lysyl Hydroxylation Causes Musculoskeletal Abnormalities in a Zebrafish Model of Bruck Syndrome.
J Bone Miner Res
2016
Danio rerio, Homo sapiens
Liu, Y; Asan, ; Ma, D; Lv, F; Xu, X; Wang, J; Xia, W; Jiang, Y; Wang, O; Xing, X; Yu, W; Wang, J; Sun, J; Song, L; Zhu, Y; Yang, H; Wang, J; Li, M
Gene mutation spectrum and genotype-phenotype correlation in a cohort of Chinese osteogenesis imperfecta patients revealed by targeted next generation sequencing.
Osteoporos Int
2017
Homo sapiens
Semkova, ME; Hsuan, JJ
TGF?-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts.
Int J Mol Sci
22
2021
Homo sapiens
Salilew-Wondim, D; Tesfaye, D; Held, E; Schellander, K; Heppelmann, M; Pfarrer, C; Bollwein, H; Hoelker, M
111 ALTERATIONS IN BOVINE ENDOMETRIAL MESSENGER AND micro RNA EXPRESSION PROFILE DUE TO CLINICAL ENDOMETRITIS.
Reprod Fertil Dev
24
168
2011
Sequoia sempervirens
Gagliano, N; Pelillo, F; Chiriva-Internati, M; Picciolini, O; Costa, F; Schutt, RC; Gioia, M; Portinaro, N
Expression profiling of genes involved in collagen turnover in tendons from cerebral palsy patients.
Connect Tissue Res
50
203-8
2009
Homo sapiens
Valverde-Franco, G; Hum, D; Matsuo, K; Lussier, B; Pelletier, JP; Fahmi, H; Kapoor, M; Martel-Pelletier, J
The in vivo effect of prophylactic subchondral bone protection of osteoarthritic synovial membrane in bone-specific Ephb4-overexpressing mice.
Am J Pathol
185
335-46
2015
Mus sp.
Hetma?czyk-Sawicka, K; Iwanicka-Nowicka, R; Fogtman, A; Cie?la, J; W?odarski, P; ?y?y?ska-Granica, B; Filocamo, M; Dardis, A; Peruzzo, P; Bednarska-Makaruk, M; Koblowska, M; ?ugowska, A
Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease.
Neurogenetics
21
105-119
2020
Homo sapiens
Knippenberg, M; Helder, MN; Doulabi, BZ; Bank, RA; Wuisman, PI; Klein-Nulend, J
Differential Effects of Bone Morphogenetic Protein-2 and Transforming Growth Factor-beta1 on Gene Expression of Collagen-Modifying Enzymes in Human Adipose Tissue-Derived Mesenchymal Stem Cells.
Tissue Eng Part A
2009
Homo sapiens
Li, X; Kim, SW; Do, KT; Ha, YK; Lee, YM; Yoon, SH; Kim, HB; Kim, JJ; Choi, BH; Kim, KS
Analyses of porcine public SNPs in coding-gene regions by re-sequencing and phenotypic association studies.
Mol Biol Rep
2010
Sus scrofa
Brommage, R; Ohlsson, C
High Fidelity of Mouse Models Mimicking Human Genetic Skeletal Disorders.
Front Endocrinol (Lausanne)
10
934
2019
Homo sapiens, Mus musculus
Zhang, WG; Chen, L; Dong, Q; He, J; Zhao, HD; Li, FL; Li, H
mmu-miR-702 functions as an anti-apoptotic mirtron by mediating ATF6 inhibition in mice.
Gene
2013
Mus musculus
Reiser, K; Summers, P; Medrano, JF; Rucker, R; Last, J; McDonald, R
Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice.
Am J Physiol
271
R696-703
1996
Mus sp.
Yates, KE; Glowacki, J
Altered expression of connective tissue genes in postnatal chondroinduced human dermal fibroblasts.
Connect Tissue Res
44
121-7
2003
Homo sapiens
Villard, C; Eriksson, P; Hanemaaijer, R; Lindeman, JH; Hultgren, R
The composition of collagen in the aneurysm wall of men and women.
J Vasc Surg
2016
Homo sapiens
Lawrence, P; Rieder, E
Insights into Jumonji C-domain containing protein 6 (JMJD6): a multifactorial role in foot-and-mouth disease virus replication in cells.
Virus Genes
53
340-351
2017
Foot-and-mouth disease virus
Zhao, J; Adams, A; Roberts, B; O'Neil, M; Vittal, A; Schmitt, T; Kumer, S; Cox, J; Li, Z; Weinman, SA; Tikhanovich, I
Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice.
Hepatology
67
1109-1126
2018
Mus sp.
Marcolin, E; San-Miguel, B; Vallejo, D; Tieppo, J; Marroni, N; González-Gallego, J; Tuñón, MJ
Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis.
J Nutr
2012
Mus sp.
Risteli, J; Koivisto, VA; Akerblom, HK; Kivirikko, KI
Intracellular enzymes of collagen biosynthesis in rat kidney in streptozotocin diabetes.
Diabetes
25
1066-70
1976
Rattus
Anttinen, H; Tuderman, L; Oikarinen, A; Kivirikko, KI
Intracellular enzymes of collagen biosynthesis in human platelets.
Blood
50
29-37
1977
Homo sapiens
Peltonen, L; Palotie, A; Myllylä, R; Krieg, T; Oikarinen, A
Collagen biosynthesis in systemic scleroderma: regulation of posttranslational modifications and synthesis of procollagen in cultured fibroblasts.
J Invest Dermatol
84
14-8
1985
Scleroderma, Homo sapiens
Myllylä, R; Alitalo, K; Vaheri, A; Kivirikko, KI
Regulation of collagen post-translational modification in transformed human and chick-embryo cells.
Biochem J
196
683-92
1981
Homo sapiens, Rous sarcoma virus, Transformation
Murad, S; Tajima, S; Johnson, GR; Sivarajah, S; Pinnell, SR
Collagen synthesis in cultured human skin fibroblasts: effect of ascorbic acid and its analogs.
J Invest Dermatol
81
158-62
1983
Homo sapiens
Last, JA; Gerriets, JE; Armstrong, LC; Gelzleichter, TR; Reiser, KM
Hydroxylation of collagen by lungs of rats administered bleomycin.
Am J Respir Cell Mol Biol
2
543-8
1990
Rattus, Homo sapiens, Metazoa, animal
Pinnell, SR; Murad, S
Effects of minoxidil on cultured human skin fibroblasts.
Dermatologica
175 Suppl 2
12-8
1987
Homo sapiens
Yamada, H; Tajima, S; Nishikawa, T; Murad, S; Pinnell, SR
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts.
J Biochem (Tokyo)
116
892-7
1994
Homo sapiens, Scleroderma
Pines, M; Schickler, M; Hurwitz, S; Yamauchi, M
Developmental changes in skin collagen biosynthesis pathway in posthatch male and female chickens.
Poult Sci
75
484-90
1996
Gallus gallus
Casey, ML; MacDonald, PC
Interstitial collagen synthesis and processing in human amnion: a property of the mesenchymal cells.
Biol Reprod
55
1253-60
1996
Homo sapiens
Nokelainen, M; Helaakoski, T; Myllyharju, J; Notbohm, H; Pihlajaniemi, T; Fietzek, PP; Kivirikko, KI
Expression and characterization of recombinant human type II collagens with low and high contents of hydroxylysine and its glycosylated forms.
Matrix Biol
16
329-38
1998
Homo sapiens
Ishida, I; Saika, S; Ohnishi, Y
Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ.
Graefes Arch Clin Exp Ophthalmol
239
770-7
2001
Oryctolagus cuniculus
Al-Hussain, H; Zeisberger, SM; Huber, PR; Giunta, C; Steinmann, B
Brittle cornea syndrome and its delineation from the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI): report on 23 patients and review of the literature.
Am J Med Genet A
124
28-34
2004
Homo sapiens, Arabia
Yamada, Y; Ando, F; Shimokata, H
Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men.
Int J Mol Med
19
791-801
2007
Homo sapiens
Ulrich, MM; Verkerk, M; Reijnen, L; Vlig, M; van den Bogaerdt, AJ; Middelkoop, E
Expression profile of proteins involved in scar formation in the healing process of full-thickness excisional wounds in the porcine model.
Wound Repair Regen
15
482-90
0
Sus scrofa, Homo sapiens, animal
YiÅŸ, U; Dirik, E; Chambaz, C; Steinmann, B; Giunta, C
Differential diagnosis of muscular hypotonia in infants: The kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI).
Neuromuscul Disord
18
210-4
2008
Homo sapiens
Hector, EE; Robins, SP; Mercer, DK; Brittenden, J; Wainwright, CL
Quantitative measurement of mature collagen cross-links in human carotid artery plaques.
Atherosclerosis
2010
Indicator, Homo sapiens
Akins, ML; Luby-Phelps, K; Bank, RA; Mahendroo, M
Cervical Softening During Pregnancy-Regulated Changes in Collagen Cross-Linking and Composition of Matricellular Proteins in the Mouse.
Biol Reprod
2011
Mus musculus, Homo sapiens, Electron
Durán, I; Marí-Beffa, M; Santamaría, JA; Becerra, J; Santos-Ruiz, L
Actinotrichia collagens and their role in fin formation.
Dev Biol
2011
Actinotrichia, Danio rerio
Kariminejad, A; Bozorgmehr, B; Khatami, A; Kariminejad, MH; Giunta, C; Steinmann, B
Ehlers-Danlos Syndrome Type VI in a 17-Year-Old Iranian Boy with Severe Muscular Weakness - A Diagnostic Challenge?
Iran J Pediatr
20
358-62
2010
Homo sapiens
Perry, JC; Guindalini, C; Bittencourt, L; Garbuio, S; Mazzotti, DR; Tufik, S
Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans.
Respir Physiol Neurobiol
2013
Homo sapiens
Rutschmann, C; Baumann, S; Cabalzar, J; Luther, KB; Hennet, T
Recombinant expression of hydroxylated human collagen in Escherichia coli.
Appl Microbiol Biotechnol
2013
Mimivirus, Escherichia coli, Homo sapiens
Abdalla, EM; Rohrbach, M; Bürer, C; Kraenzlin, M; El-Tayeby, H; Elbelbesy, MF; Nabil, A; Giunta, C
Kyphoscoliotic type of Ehlers-Danlos Syndrome (EDS VIA) in six Egyptian patients presenting with a homogeneous clinical phenotype.
Eur J Pediatr
174
105-12
2015
Homo sapiens
Tausendschön, M; Rehli, M; Dehne, N; Schmidl, C; Döring, C; Hansmann, ML; Brüne, B
Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10.
Biochim Biophys Acta
1849
10-22
2015
Homo sapiens, Areas
Alahari, S; Post, M; Caniggia, I
Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta.
Endocrinology
156
3012-25
2015
Homo sapiens
Qian, S; Wang, Y; Ma, H; Zhang, L
Expansion and Functional Divergence of Jumonji C-Containing Histone Demethylases: Significance of Duplications in Ancestral Angiosperms and Vertebrates.
Plant Physiol
168
1321-37
2015
Fungi, Metazoa
Zhang, X; Gao, Y; Lu, L; Zhang, Z; Gan, S; Xu, L; Lei, A; Cao, Y
JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis.
J Biol Chem
290
20273-83
2015
Xenopus
Lawrence, P; Pacheco, J; Stenfeldt, C; Arzt, J; Rai, DK; Rieder, E
Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: Impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of inoculation.
Virology
492
108-117
2016
Bos taurus, Foot-and-mouth disease virus, animal
Hu, YJ; Imbalzano, AN
Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts.
Sci Data
3
160022
2016
Mus musculus
Shin, JY; Son, J; Kim, WS; Gwak, J; Ju, BG
Jmjd6a regulates GSK3? RNA splicing in Xenopus laevis eye development.
PLoS One
14
e0219800
2019
Xenopus
Micha, D; Pals, G; Smit, TH; Ghazanfari, S
An in vitro model to evaluate the properties of matrices produced by fibroblasts from osteogenesis imperfecta and Ehlers-Danlos Syndrome patients.
Biochem Biophys Res Commun
521
310-317
2020
Homo sapiens
Watson, CJ; Monstad-Rios, AT; Bhimani, RM; Gistelinck, C; Willaert, A; Coucke, P; Hsu, YH; Kwon, RY
Phenomics-Based Quantification of CRISPR-Induced Mosaicism in Zebrafish.
Cell Syst
2020
Homo sapiens
Pfeffer, T; Lignelli, E; Inoue, H; Mižíková, I; Surate Solaligue, DE; Steenbock, H; Myti, D; Vadász, I; Herold, S; Seeger, W; Brinckmann, J; Morty, RE
Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.
J Pharmacol Exp Ther
375
478-487
2020
Mus musculus, Mus sp., Homo sapiens, animal
Reiter, S; Wallner, B; Brem, G; Haring, E; Hoelzle, L; Stefaniuk-Szmukier, M; D?ugosz, B; Piórkowska, K; Ropka-Molik, K; Malvick, J; Penedo, MCT; Bellone, RR
Distribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G>A) in Different Horse Breeds from Europe and the United States.
Genes (Basel)
11
2020
Equus caballus, Equidae
Pöschel, A; Beebe, E; Kunz, L; Amini, P; Guscetti, F; Malbon, A; Markkanen, E
Identification of disease-promoting stromal components by comparative proteomic and transcriptomic profiling of canine mammary tumors using laser-capture microdissected FFPE tissue.
Neoplasia
23
400-412
2021
Homo sapiens
Koenig, SN; Cavus, O; Williams, J; Bernier, M; Tonniges, J; Sucharski, H; Dew, T; Akel, M; Baker, P; Madiai, F; De Giorgi, F; Scietti, L; Faravelli, S; Forneris, F; Mohler, PJ; Bradley, EA
New mechanistic insights to PLOD1-mediated human vascular disease.
Transl Res
2021
Homo sapiens
Cohen, C; Leal, MF; Belangero, PS; Figueiredo, EA; Smith, MC; Andreoli, CV; de Castro Pochini, A; Cohen, M; Ejnisman, B; Faloppa, F
The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study.
Clinics (Sao Paulo)
71
325-31
2016
Homo sapiens
Kurozumi, A; Kato, M; Goto, Y; Matsushita, R; Nishikawa, R; Okato, A; Fukumoto, I; Ichikawa, T; Seki, N
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Int J Oncol
48
1837-46
2016
Homo sapiens
Choi, SK; Kim, HS; Jin, T; Moon, WK
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Oncotarget
8
11977-11989
2017
Mus musculus
Chichester, CO; Fuller, GC
Evidence for the presence of an endogenous inhibition of prolyl hydroxylase.
Res Commun Chem Pathol Pharmacol
29
329-38
1980
Oryctolagus cuniculus
Saika, S; Hashizume, N; Okada, Y; Kobata, S; Yamanaka, O; Uenoyama, K; Ooshima, A
Prolyl hydroxylase inhibitor and lysyl hydroxylase inhibitor inhibit spreading of corneal epithelium.
Graefes Arch Clin Exp Ophthalmol
232
499-502
1994
Oryctolagus cuniculus
Ryhänen, L
Hydroxylation of lysyl residues in lysine-rich and arginine-rich histones by lysyl hydroxylase in vitro.
Biochim Biophys Acta
397
50-7
1975
other sequences
Steinmann, B; Gitzelmann, R; Vogel, A; Grant, ME; Harwood, R; Sear, CH
Ehlers-Danlos syndrome in two siblings with deficient lysyl hydroxylase activity in cultured skin fibroblasts but only mild hydroxylysine deficit in skin.
Helv Paediatr Acta
30
255-74
1975
Homo sapiens
Murad, S; Tennant, MC; Pinnell, SR
Structure-activity relationship of minoxidil analogs as inhibitors of lysyl hydroxylase in cultured fibroblasts.
Arch Biochem Biophys
292
234-8
1992
Homo sapiens
Hyland, J; Ala-Kokko, L; Royce, P; Steinmann, B; Kivirikko, KI; Myllylä, R
A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers-Danlos syndrome type VI.
Nat Genet
2
228-31
1992
Homo sapiens
Ananthanarayanan, VS; Saint-Jean, A; Jiang, P
Conformation of a synthetic hexapeptide substrate of collagen lysyl hydroxylase.
Arch Biochem Biophys
298
21-8
1992
Gallus gallus
Myllylä, R; Pihlajaniemi, T; Pajunen, L; Turpeenniemi-Hujanen, T; Kivirikko, KI
Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase.
J Biol Chem
266
2805-10
1991
Areas
Jiang, P; Ananthanarayanan, VS
Conformational requirement for lysine hydroxylation in collagen. Structural studies on synthetic peptide substrates of lysyl hydroxylase.
J Biol Chem
266
22960-7
1991
Gallus gallus
Murad, S; Pinnell, SR
Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
J Biol Chem
262
11973-8
1987
Homo sapiens
Royce, PM; Moser, U; Steinmann, B
Ehlers-Danlos syndrome type VI with normal lysyl hydroxylase activity cannot be explained by a defect in cellular uptake of ascorbic acid.
Matrix
9
147-9
1989
Homo sapiens
Wenstrup, RJ; Murad, S; Pinnell, SR
Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.
J Pediatr
115
405-9
1989
Homo sapiens
Dembure, PP; Priest, JH; Snoddy, SC; Elsas, LJ
Genotyping and prenatal assessment of collagen lysyl hydroxylase deficiency in a family with Ehlers-Danlos syndrome type VI.
Am J Hum Genet
36
783-90
1984
Homo sapiens
Pousi, B; Hautala, T; Heikkinen, J; Pajunen, L; Kivirikko, KI; Myllylä, R
Alu-Alu recombination results in a duplication of seven exons in the lysyl hydroxylase gene in a patient with the type VI variant of Ehlers-Danlos syndrome.
Am J Hum Genet
55
899-906
1994
Homo sapiens
Ha, VT; Marshall, MK; Elsas, LJ; Pinnell, SR; Yeowell, HN
A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase gene.
J Clin Invest
93
1716-21
1994
Homo sapiens
Handa, JT; Murad, S; Jaffe, GJ
Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity.
Invest Ophthalmol Vis Sci
34
567-75
1993
Homo sapiens
Hautala, T; Heikkinen, J; Kivirikko, KI; Myllylä, R
A large duplication in the gene for lysyl hydroxylase accounts for the type VI variant of Ehlers-Danlos syndrome in two siblings.
Genomics
15
399-404
1993
Homo sapiens
Heikkinen, J; Toppinen, T; Yeowell, H; Krieg, T; Steinmann, B; Kivirikko, KI; Myllylä, R
Duplication of seven exons in the lysyl hydroxylase gene is associated with longer forms of a repetitive sequence within the gene and is a common cause for the type VI variant of Ehlers-Danlos syndrome.
Am J Hum Genet
60
48-56
1997
Homo sapiens
Yeowell, HN; Walker, LC
Ehlers-Danlos syndrome type VI results from a nonsense mutation and a splice site-mediated exon-skipping mutation in the lysyl hydroxylase gene.
Proc Assoc Am Physicians
109
383-96
1997
Homo sapiens
Pajunen, L; Suokas, M; Hautala, T; Kellokumpu, S; Tebbe, B; Kivirikko, KI; Myllylä, R
A splice-site mutation that induces exon skipping and reduction in lysyl hydroxylase mRNA levels but does not create a nonsense codon in Ehlers-Danlos syndrome type VI.
DNA Cell Biol
17
117-23
1998
insertion sequences
Brinckmann, J; Açil, Y; Feshchenko, S; Katzer, E; Brenner, R; Kulozik, A; Kügler, S
Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
Arch Dermatol Res
290
181-6
1998
Homo sapiens
Walker, LC; Marini, JC; Grange, DK; Filie, J; Yeowell, HN
A patient with Ehlers-Danlos syndrome type VI is homozygous for a premature termination codon in exon 14 of the lysyl hydroxylase 1 gene.
Mol Genet Metab
67
74-82
1999
Homo sapiens
Heikkinen, J; Pousi, B; Pope, M; Myllylä, R
A null-mutated lysyl hydroxylase gene in a compound heterozygote British patient with Ehlers-Danlos syndrome type VI.
Hum Mutat
14
351
1999
insertion sequences, Homo sapiens
Yeowell, HN; Allen, JD; Walker, LC; Overstreet, MA; Murad, S; Thai, SF
Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI.
Matrix Biol
19
37-46
2000
Homo sapiens
Wang, C; Valtavaara, M; Myllylä, R
Lack of collagen type specificity for lysyl hydroxylase isoforms.
DNA Cell Biol
19
71-7
2000
Homo sapiens, Mus musculus
Heikkinen, J; Risteli, M; Wang, C; Latvala, J; Rossi, M; Valtavaara, M; Myllylä, R
Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.
J Biol Chem
275
36158-63
2000
Homo sapiens, Gallus gallus
Yeowell, HN; Walker, LC
Mutations in the lysyl hydroxylase 1 gene that result in enzyme deficiency and the clinical phenotype of Ehlers-Danlos syndrome type VI.
Mol Genet Metab
71
212-24
0
Homo sapiens
Hjalt, TA; Amendt, BA; Murray, JC
PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome.
J Cell Biol
152
545-52
2001
Mus musculus, Homo sapiens
Rauma, T; Kumpumäki, S; Anderson, R; Davidson, BL; Ruotsalainen, H; Myllylä, R; Hautala, T
Adenoviral gene transfer restores lysyl hydroxylase activity in type VI Ehlers-Danlos syndrome.
J Invest Dermatol
116
602-5
2001
Homo sapiens, Rattus, Rodentia
Samimi, A; Last, JA
Inhibition of lysyl hydroxylase by malathion and malaoxon.
Toxicol Appl Pharmacol
172
203-9
2001
Rattus, Starmerella aceti
van der Slot, AJ; Zuurmond, AM; van den Bogaerdt, AJ; Ulrich, MM; Middelkoop, E; Boers, W; Karel Ronday, H; DeGroot, J; Huizinga, TW; Bank, RA
Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon.
Matrix Biol
23
251-7
2004
Homo sapiens
Ha-Vinh, R; Alanay, Y; Bank, RA; Campos-Xavier, AB; Zankl, A; Superti-Furga, A; Bonafé, L
Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2.
Am J Med Genet A
131
115-20
2004
Homo sapiens, Pterygia
van der Slot, AJ; van Dura, EA; de Wit, EC; De Groot, J; Huizinga, TW; Bank, RA; Zuurmond, AM
Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.
Biochim Biophys Acta
1741
95-102
2005
Homo sapiens
Giunta, C; Randolph, A; Steinmann, B
Mutation analysis of the PLOD1 gene: an efficient multistep approach to the molecular diagnosis of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA).
Mol Genet Metab
86
269-76
0
Homo sapiens
Brinckmann, J; Kim, S; Wu, J; Reinhardt, DP; Batmunkh, C; Metzen, E; Notbohm, H; Bank, RA; Krieg, T; Hunzelmann, N
Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
Matrix Biol
24
459-68
2005
Scleroderma
Myllylä, R; Wang, C; Heikkinen, J; Juffer, A; Lampela, O; Risteli, M; Ruotsalainen, H; Salo, A; Sipilä, L
Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3).
J Cell Physiol
212
323-9
2007
Danio rerio, Mus musculus, Mus sp.
Cudic, M; Patel, DA; Lauer-Fields, JL; Brew, K; Fields, GB
Development of a convenient peptide-based assay for lysyl hydroxylase.
Biopolymers
90
330-8
2008
Varanidae, Mammalia, Areas
Hahn, P; Böse, J; Edler, S; Lengeling, A
Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.
BMC Genomics
9
293
2008
Mus sp., Mammalia, Phyla
Seth, P; Yeowell, HN
Fox-2 protein regulates the alternative splicing of scleroderma-associated lysyl hydroxylase 2 messenger RNA.
Arthritis Rheum
62
1167-75
2010
Homo sapiens, Mus musculus, Scleroderma
Kubota, M; Shinoda, A; Iguchi, K; Takahashi, Y; Usui, S; Kiho, T; Hirano, K
Up-regulation of the lysyl hydroxylase 2 gene by acetaminophen and isoniazid is modulated by transcription factor c-Myb.
J Pharm Pharmacol
62
477-84
2010
Homo sapiens
Puig-Hervás, MT; Temtamy, S; Aglan, M; Valencia, M; Martínez-Glez, V; Ballesta-Martínez, MJ; López-González, V; Ashour, AM; Amr, K; Pulido, V; Guillén-Navarro, E; Lapunzina, P; Caparrós-Martín, JA; Ruiz-Perez, VL
Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-Osteogenesis imperfecta phenotypic spectrum.
Hum Mutat
33
1444-9
2012
Homo sapiens
Chong, MS; Goh, LK; Lim, WS; Chan, M; Tay, L; Chen, G; Feng, L; Ng, TP; Tan, CH; Lee, TS
Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.
J Alzheimers Dis
34
399-405
2013
Homo sapiens
Zhang, J; Ni, SS; Zhao, WL; Dong, XC; Wang, JL
High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma.
Tumour Biol
34
2397-401
2013
Homo sapiens
Witsch, TJ; Turowski, P; Sakkas, E; Niess, G; Becker, S; Herold, S; Mayer, K; Vadász, I; Roberts, JD; Seeger, W; Morty, RE
Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.
Am J Physiol Lung Cell Mol Physiol
306
L246-59
2014
Homo sapiens, Mus musculus, Septa, animal
Wang, F; He, L; Huangyang, P; Liang, J; Si, W; Yan, R; Han, X; Liu, S; Gui, B; Li, W; Miao, D; Jing, C; Liu, Z; Pei, F; Sun, L; Shang, Y
JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.
PLoS Biol
12
e1001819
2014
Homo sapiens
Chen, CF; Feng, X; Liao, HY; Jin, WJ; Zhang, J; Wang, Y; Gong, LL; Liu, JJ; Yuan, XH; Zhao, BB; Zhang, D; Chen, GF; Wan, Y; Guo, J; Yan, HP; He, YW
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Sci Rep
4
6359
2014
Homo sapiens, Hepatitis B virus
Tosun, A; Kurtgoz, S; Dursun, S; Bozkurt, G
A case of Ehlers-Danlos syndrome type VIA with a novel PLOD1 gene mutation.
Pediatr Neurol
51
566-9
2014
Homo sapiens
Poulard, C; Rambaud, J; Lavergne, E; Jacquemetton, J; Renoir, JM; Trédan, O; Chabaud, S; Treilleux, I; Corbo, L; Le Romancer, M
Role of JMJD6 in Breast Tumourigenesis.
PLoS One
10
e0126181
2015
Homo sapiens, Mus sp.
Yanagihara, T; Sanematsu, F; Sato, T; Uruno, T; Duan, X; Tomino, T; Harada, Y; Watanabe, M; Wang, Y; Tanaka, Y; Nakanishi, Y; Suyama, M; Yoshinori, F
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nat Commun
6
8820
2015
Mus sp.
Lee, CR; Lee, SH; Rigas, NK; Kim, RH; Kang, MK; Park, NH; Shin, KH
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Carcinogenesis
37
119-28
2016
Homo sapiens
Miyamoto, K; Seki, N; Matsushita, R; Yonemori, M; Yoshino, H; Nakagawa, M; Enokida, H
Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer.
Br J Cancer
115
354-63
2016
Homo sapiens
Yi, J; Shen, HF; Qiu, JS; Huang, MF; Zhang, WJ; Ding, JC; Zhu, XY; Zhou, Y; Fu, XD; Liu, W
JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner.
Nucleic Acids Res
45
3503-3518
2017
Mus sp.
Song, Y; Zheng, S; Wang, J; Long, H; Fang, L; Wang, G; Li, Z; Que, T; Liu, Y; Li, Y; Zhang, X; Fang, W; Qi, S
Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.
Oncotarget
8
41947-41962
2017
Homo sapiens
Xu, F; Zhang, J; Hu, G; Liu, L; Liang, W
Hypoxia and TGF-?1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation.
Cancer Cell Int
17
54
2017
Homo sapiens
Vangimalla, SS; Ganesan, M; Kharbanda, KK; Osna, NA
Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
Biomolecules
7
2017
Foot-and-mouth disease virus
Miotti, S; Gulino, A; Ferri, R; Parenza, M; Chronowska, A; Lecis, D; Sangaletti, S; Tagliabue, E; Tripodo, C; Colombo, MP
Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.
FASEB J
2017
Homo sapiens
Zhang, Z; Yang, Y; Zhang, X
MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/?-catenin pathway in non-small cell lung cancer.
Life Sci
188
163-171
2017
animal
Shen, Q; Eun, JW; Lee, K; Kim, HS; Yang, HD; Kim, SY; Lee, EK; Kim, T; Kang, K; Kim, S; Min, DH; Oh, SN; Lee, YJ; Moon, H; Ro, SW; Park, WS; Lee, JY; Nam, SW
Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma.
Hepatology
67
1360-1377
2018
Homo sapiens, Transformation
Du, H; Chen, Y; Hou, X; Huang, Y; Wei, X; Yu, X; Feng, S; Wu, Y; Zhan, M; Shi, X; Lin, S; Lu, L; Yuan, S; Sun, L
PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC.
Cell Death Dis
8
e3143
2017
Homo sapiens
Lv, F; Xu, X; Song, Y; Li, L; Asan, ; Wang, J; Yang, H; Wang, O; Jiang, Y; Xia, W; Xing, X; Li, M
Novel Mutations in PLOD2 Cause Rare Bruck Syndrome.
Calcif Tissue Int
102
296-309
2018
Homo sapiens
Leal, GF; Nishimura, G; Voss, U; Bertola, DR; Åström, E; Svensson, J; Yamamoto, GL; Hammarsjö, A; Horemuzova, E; Papadiogannakis, N; Iwarsson, E; Grigelioniene, G; Tham, E
Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2.
J Bone Miner Res
2017
Homo sapiens, Pterygia
Liu, X; Si, W; Liu, X; He, L; Ren, J; Yang, Z; Yang, J; Li, W; Liu, S; Pei, F; Yang, X; Sun, L
JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component.
Mol Cancer
16
175
2017
Gallus gallus
Alahari, S; Post, M; Rolfo, A; Weksberg, R; Caniggia, I
Compromised JMJD6 histone demethylase activity impacts on VHL gene repression in preeclampsia.
J Clin Endocrinol Metab
2018
Homo sapiens, Mus sp.
Kiyozumi, Y; Iwatsuki, M; Kurashige, J; Ogata, Y; Yamashita, K; Koga, Y; Toihata, T; Hiyoshi, Y; Ishimoto, T; Baba, Y; Miyamoto, Y; Yoshida, N; Yanagihara, K; Mimori, K; Baba, H
PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer.
Int J Cancer
2018
clinical samples
Tsai, CK; Huang, LC; Tsai, WC; Huang, SM; Lee, JT; Hueng, DY
Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas.
Oncotarget
9
15705-15720
2018
Homo sapiens, Mus musculus
Okumura, Y; Noda, T; Eguchi, H; Sakamoto, T; Iwagami, Y; Yamada, D; Asaoka, T; Wada, H; Kawamoto, K; Gotoh, K; Kobayashi, S; Takeda, Y; Tanemura, M; Umeshita, K; Doki, Y; Mori, M
Hypoxia-Induced PLOD2 is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Ann Surg Oncol
25
3728-3737
2018
Homo sapiens
Baek, JH; Yun, HS; Kwon, GT; Kim, JY; Lee, CW; Song, JY; Um, HD; Kang, CM; Park, JK; Kim, JS; Kim, EH; Hwang, SG
PLOD3 promotes lung metastasis via regulation of STAT3.
Cell Death Dis
9
1138
2018
Homo sapiens, Mus musculus, animal
Shao, S; Zhang, X; Duan, L; Fang, H; Rao, S; Liu, W; Guo, B; Zhang, X
Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-??/Smad3 Signaling Pathway.
Med Sci Monit
24
8592-8601
2018
Homo sapiens, Mus sp.
Anelli, V; Ordas, A; Kneitz, S; Sagredo, LM; Gourain, V; Schartl, M; Meijer, AH; Mione, M
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
Front Genet
9
675
2018
Chondrichthyes, Danio rerio, Homo sapiens
Di, WY; Kang, XH; Zhang, JH; Wang, Y; Kou, WZ; Su, W
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Zhonghua Bing Li Xue Za Zhi
48
102-107
2019
Homo sapiens
Scietti, L; Campioni, M; Forneris, F
SiMPLOD, a structure-integrated database of collagen lysyl hydroxylase (LH/PLOD) enzyme variants.
J Bone Miner Res
2019
Homo sapiens
Wang, B; Xu, L; Ge, Y; Cai, X; Li, Q; Yu, Z; Wang, J; Wang, Y; Lu, C; Wang, D; Wang, Y; Chen, X; Gu, Y
PLOD3 is Upregulated in Gastric Cancer and Correlated with Clinicopathologic Characteristics.
Clin Lab
65
2019
Homo sapiens, clinical samples
He, J; Wei, X; Li, S; Quan, X; Li, R; Du, H; Yuan, S; Sun, L
DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.
Phytomedicine
59
152778
2019
Mus musculus, Tuber
Ewans, LJ; Colley, A; Gaston-Massuet, C; Gualtieri, A; Cowley, MJ; McCabe, MJ; Anand, D; Lachke, SA; Scietti, L; Forneris, F; Zhu, Y; Ying, K; Walsh, C; Kirk, EP; Miller, D; Giunta, C; Sillence, D; Dinger, M; Buckley, M; Roscioli, T
Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications.
J Med Genet
56
629-638
2019
Homo sapiens
Islam, MS; McDonough, MA; Chowdhury, R; Gault, J; Khan, A; Pires, E; Schofield, CJ
Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
J Biol Chem
294
11637-11652
2019
Homo sapiens
Yamada, Y; Kato, M; Arai, T; Sanada, H; Uchida, A; Misono, S; Sakamoto, S; Komiya, A; Ichikawa, T; Seki, N
Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target.
Mol Oncol
13
1898-1912
2019
Homo sapiens
Cao, F; Kang, XH; Cui, YH; Wang, Y; Zhao, KL; Wang, YN; Kou, WZ; Miao, ZH; Cao, XJ
[Upregulation of PLOD2 promotes invasion and metastasis of osteosarcoma cells].
Zhonghua Zhong Liu Za Zhi
41
435-440
2019
Homo sapiens
Wong, M; Sun, Y; Xi, Z; Milazzo, G; Poulos, RC; Bartenhagen, C; Bell, JL; Mayoh, C; Ho, N; Tee, AE; Chen, X; Li, Y; Ciaccio, R; Liu, PY; Jiang, CC; Lan, Q; Jayatilleke, N; Cheung, BB; Haber, M; Norris, MD; Zhang, XD; Marshall, GM; Wang, JY; Hüttelmaier, S; Fischer, M; Wong, JWH; Xu, H; Perini, G; Dong, Q; George, RE; Liu, T
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.
Nat Commun
10
3319
2019
Homo sapiens, Mus sp.
Rosell-García, T; Palomo-Álvarez, O; Rodríguez-Pascual, F
A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor ?1.
J Biol Chem
2019
Homo sapiens, Mus musculus
Reyes-Gutierrez, P; Carrasquillo-Rodríguez, JW; Imbalzano, AN
Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function.
PLoS One
14
e0216015
2019
animal
Sheng, X; Li, Y; Li, Y; Liu, W; Lu, Z; Zhan, J; Xu, M; Chen, L; Luo, X; Cai, G; Zhang, S
PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics.
BMC Cancer
19
840
2019
Homo sapiens
Mumm, S; Gottesman, GS; Wenkert, D; Campeau, PM; Nenninger, A; Huskey, M; Bijanki, VN; Veis, DJ; Barnes, AM; Marini, JC; Stolina, M; Zhang, F; McAlister, WH; Whyte, MP
Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
Bone
115047
2019
Homo sapiens, Pterygia
Taler, K; Weiss, O; Rotem-Bamberger, S; Rubinstein, AM; Seritrakul, P; Gross, JM; Inbal, A
Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate.
Dev Biol
458
177-188
2020
Danio rerio
Hu, HL; Wang, CF; Wei, XH; Lv, JX; Cao, XH; Shi, YY; Han, LF; Zhang, YN
Correlation between procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 and breast cancer.
Int J Clin Exp Pathol
12
1015-1021
2019
Homo sapiens
Ueki, Y; Saito, K; Iioka, H; Sakamoto, I; Kanda, Y; Sakaguchi, M; Horii, A; Kondo, E
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
iScience
23
100850
2020
Homo sapiens
Wang, X; Guo, J; Dai, M; Wang, T; Yang, T; Xiao, X; Tang, Q; Zhang, L; Jia, L
PLOD2 increases resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis.
J Cancer
11
3467-3475
2020
Mus musculus
Wu, X; Xiang, H; Cong, W; Yang, H; Zhang, G; Wang, Y; Guo, Z; Shen, Y; Chen, B
PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma.
Biochem Biophys Res Commun
527
29-36
2020
Mus sp., Lentivirus
Ni, X; Jin, C; Jiang, Y; Wang, O; Li, M; Xing, X; Xia, W
The first case report of Kyphoscoliotic Ehlers-Danlos syndrome of chinese origin with a novel PLOD1 gene mutation.
BMC Med Genet
21
214
2020
Homo sapiens
Jiang, H; Guo, W; Yuan, S; Song, L
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Biomed Res Int
2020
3418398
2020
Homo sapiens
Zhao, YF; Li, L; Li, HJ; Yang, FR; Liu, ZK; Hu, XW; Wang, Q
LncRNA ZFPM2-AS1 aggravates the malignant development of breast cancer via upregulating JMJD6.
Eur Rev Med Pharmacol Sci
24
11139-11147
2020
Mus sp.
Biswas, A; Mukherjee, G; Kondaiah, P; Desai, KV
Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer.
BMC Cancer
20
1159
2020
Homo sapiens, clinical samples
Wang, H; Luo, W; Dai, L
Expression and Prognostic Role of PLOD1 in Malignant Glioma.
Onco Targets Ther
13
13285-13297
2020
Homo sapiens
Wang, Z; Shi, Y; Ying, C; Jiang, Y; Hu, J
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Oncogene
40
1458-1475
2021
Homo sapiens, clinical samples
Zhang, C; Lu, X; Huang, J; He, H; Chen, L; Liu, Y; Wang, H; Xu, Y; Xing, S; Ruan, X; Yang, X; Chen, L; Xu, D
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.
Clin Transl Med
11
e328
2021
Homo sapiens
Zhang, W; Wang, Q; Yang, F; Zhu, Z; Duan, Y; Yang, Y; Cao, W; Zhang, K; Ma, J; Liu, X; Zheng, H
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.
PLoS Pathog
17
e1009366
2021
Mus sp., Murine respirovirus, vesicular stomatitis virus
Gistelinck, C; Weis, M; Rai, J; Schwarze, U; Niyazov, D; Song, KM; Byers, PH; Eyre, DR
Abnormal Bone Collagen Cross-Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations.
JBMR Plus
5
e10454
2021
Homo sapiens
Cheriyamundath, S; Kumar, A; Gavert, N; Brabletz, T; Ben-Ze'ev, A
The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Int J Mol Sci
22
2021
Areas, Homo sapiens
Tian, L; Zhou, H; Wang, G; Wang, WY; Li, Y; Xue, X
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.
PeerJ
9
e11422
2021
Homo sapiens, Indicator
Cao, C; Ma, Q; Huang, X; Li, A; Liu, J; Ye, J; Gui, Y
Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.
Front Mol Biosci
8
675683
2021
Homo sapiens, Indicator
Li, G; Wang, X; Liu, G
PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Biomed Res Int
2021
5512340
2021
Homo sapiens
Min, W; Begley, TP; Myllyharju, J; Kivirikko, KI
Mechanistic Studies on Prolyl-4-Hydroxylase: Demonstration That the Ferryl Intermediate Does Not Exchange with Water.
BIO-ORGANIC CHEMISTRY
28
261-265
2000
Homo sapiens
Böttger, A; Islam, MS; Chowdhury, R; Schofield, CJ; Wolf, A
The oxygenase Jmjd6--a case study in conflicting assignments.
Biochem J
468
191-202
2015
Homo sapiens, Areas
Schneider, VA; Granato, M
The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration.
Neuron
50
683-95
2006
Danio rerio
Galkina, SI; Fedorova, NV; Ksenofontov, AL; Serebryakova, MV; Golenkina, EA; Stadnichuk, VI; Baratova, LA; Sud'ina, GF
Neutrophil Adhesion and the Release of the Free Amino Acid Hydroxylysine.
Cells
10
2021
Electron
Buga, AM; Margaritescu, C; Scholz, CJ; Radu, E; Zelenak, C; Popa-Wagner, A
Transcriptomics of post-stroke angiogenesis in the aged brain.
Front Aging Neurosci
6
44
2014
Lamina, Metazoa, Rattus
Lim, PJ; Lindert, U; Opitz, L; Hausser, I; Rohrbach, M; Giunta, C
Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between PLOD1- and FKBP14-Kyphoscoliotic Ehlers-Danlos Syndrome.
Genes (Basel)
10
2019
Homo sapiens
Kaneto, CM; Lima, PS; Zanette, DL; Oliveira, TY; de Assis Pereira, F; Lorenzi, JC; Dos Santos, JL; Prata, KL; Neto, JM; de Paula, FJ; Silva, WA
Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome.
BMC Med Genet
17
38
2016
Terminator
Mia, MM; Bank, RA
The I?B kinase inhibitor ACHP strongly attenuates TGF?1-induced myofibroblast formation and collagen synthesis.
J Cell Mol Med
19
2780-92
2015
Homo sapiens
Gawel, DR; Lee, EJ; Li, X; Lilja, S; Matussek, A; Schäfer, S; Olsen, RS; Stenmarker, M; Zhang, H; Benson, M
An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer.
Sci Rep
9
15575
2019
Homo sapiens
Guo, B; Wang, L; Qin, X; Shen, Y; Ma, C
Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis.
Oncol Lett
18
5843-5852
2019
Homo sapiens
Guo, T; Gu, C; Li, B; Xu, C
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.
Lab Invest
101
564-569
2021
Mus musculus
van Vlimmeren, MA; Driessen-Mol, A; van den Broek, M; Bouten, CV; Baaijens, FP
Controlling matrix formation and cross-linking by hypoxia in cardiovascular tissue engineering.
J Appl Physiol
2010
Homo sapiens
Clark, CC; Richards, CF
Underhydroxylated minor cartilage collagen precursors cannot form stable triple helices.
Biochem J
250
65-70
1988
Sterna, Chelator
Shen, Q; Nam, SW
SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma.
BMB Rep
51
57-58
2018
Homo sapiens
Venables, JP; Lapasset, L; Gadea, G; Fort, P; Klinck, R; Irimia, M; Vignal, E; Thibault, P; Prinos, P; Chabot, B; Abou Elela, S; Roux, P; Lemaitre, JM; Tazi, J
MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.
Nat Commun
4
2480
2013
vertebrata
Uitto, J; Lichtenstein, JR
Defects in the biochemistry of collagen in diseases of connective tissue.
J Invest Dermatol
66
59-79
1976
Homo sapiens
Pinnell, SR
Molecular defects in the Ehlers-Danlos syndrome.
J Invest Dermatol
79 Suppl 1
90s-92s
1982
Homo sapiens
Saito, M; Soshi, S; Fujii, K
Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts.
J Bone Miner Res
18
1695-705
2003
Mus musculus
Maller, O; Drain, AP; Barrett, AS; Borgquist, S; Ruffell, B; Zakharevich, I; Pham, TT; Gruosso, T; Kuasne, H; Lakins, JN; Acerbi, I; Barnes, JM; Nemkov, T; Chauhan, A; Gruenberg, J; Nasir, A; Bjarnadottir, O; Werb, Z; Kabos, P; Chen, YY; Hwang, ES; Park, M; Coussens, LM; Nelson, AC; Hansen, KC; Weaver, VM
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Nat Mater
2020
Homo sapiens
Ma, CG; Xu, WH; Xu, Y; Wang, J; Liu, WR; Cao, DL; Wang, HK; Shi, GH; Zhu, YP; Qu, YY; Zhang, HL; Ye, DW
Identification and validation of novel metastasis-related signatures of clear cell renal cell carcinoma using gene expression databases.
Am J Transl Res
12
4108-4126
2020
Homo sapiens
Pinnell, SR
Regulation of collagen biosynthesis by ascorbic acid: a review.
Yale J Biol Med
58
553-9
0
Homo sapiens
Myllylä, R; Tryggvason, K; Kivirikko, KI; Reddi, AH
Changes in intracellular enzymes of collagen biosynthesis during matrix-induced cartilage and bone development.
Biochim Biophys Acta
674
238-45
1981
Rattus
Ishikawa, Y; Taga, Y; Zientek, K; Mizuno, N; Salo, AM; Semenova, O; Tufa, SF; Keene, DR; Holden, P; Mizuno, K; Gould, DB; Myllyharju, J; Bächinger, HP
Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER.
J Biol Chem
296
100453
0
Homo sapiens, Mus sp.
Khalifa, A; Cohen, MP
Glomerular protocollagen lysyl-hydroxylase activity in streptozotocin diabetes.
Biochim Biophys Acta
386
332-9
1975
Rattus
Royce, PM; Steinmann, B; Vogel, A; Steinhorst, U; Kohlschuetter, A
Brittle cornea syndrome: an heritable connective tissue disorder distinct from Ehlers-Danlos syndrome type VI and fragilitas oculi, with spontaneous perforations of the eye, blue sclerae, red hair, and normal collagen lysyl hydroxylation.
Eur J Pediatr
149
465-9
1990
Ursidae, Electron
Dembure, PP; Janko, AR; Priest, JH; Elsas, LJ
Ascorbate regulation of collagen biosynthesis in Ehlers-Danlos syndrome, type VI.
Metabolism
36
687-91
1987
Homo sapiens
Sussman, M; Lichtenstein, JR; Nigra, TP; Martin, GR; McKusick, VA
Hydroxylysine-deficient skin collagen in a patient with a form of the Ehlers-Danlos syndrome.
J Bone Joint Surg Am
56
1228-34
1974
Homo sapiens
Murad, S; Grove, D; Lindberg, KA; Reynolds, G; Sivarajah, A; Pinnell, SR
Regulation of collagen synthesis by ascorbic acid.
Proc Natl Acad Sci U S A
78
2879-82
1981
Homo sapiens
Mahé, YF; Buan, B; Bernard, BA
A minoxidil-related compound lacking a C6 substitution still exhibits strong anti-lysyl hydroxylase activity in vitro.
Skin Pharmacol
9
177-83
1996
Scleroderma
Yeowell, HN; Walker, LC
Prenatal exclusion of Ehlers-Danlos syndrome type VI by mutational analysis.
Proc Assoc Am Physicians
111
57-62
0
Homo sapiens
Cox, CJ; Espinoza, HM; McWilliams, B; Chappell, K; Morton, L; Hjalt, TA; Semina, EV; Amendt, BA
Differential regulation of gene expression by PITX2 isoforms.
J Biol Chem
277
25001-10
2002
Cricetulus griseus
Eyre, D; Shao, P; Weis, MA; Steinmann, B
The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine.
Mol Genet Metab
76
211-6
2002
Homo sapiens
Walker, LC; Overstreet, MA; Willing, MC; Marini, JC; Cabral, WA; Pals, G; Bristow, J; Atsawasuwan, P; Yamauchi, M; Yeowell, HN
Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation.
Am J Med Genet A
131
155-62
2004
Homo sapiens
Giunta, C; Randolph, A; Al-Gazali, LI; Brunner, HG; Kraenzlin, ME; Steinmann, B
Nevo syndrome is allelic to the kyphoscoliotic type of the Ehlers-Danlos syndrome (EDS VIA).
Am J Med Genet A
133
158-64
2005
Homo sapiens
Iguchi, K; Takahashi, Y; Kaneto, Y; Kubota, M; Usui, S; Hirano, K
Identification of differentially expressed genes in hepatic HepG2 cells treated with acetaminophen using suppression subtractive hybridization.
Biol Pharm Bull
28
1148-53
2005
Mus sp.
Yeowell, HN; Walker, LC; Neumann, LM
An Ehlers-Danlos syndrome type VIA patient with cystic malformations of the meninges.
Eur J Dermatol
15
353-8
0
Homo sapiens
Salavoura, K; Valari, M; Kolialexi, A; Mavrou, A; Kitsiou, S
A case of Ehlers Danlos syndrome type VI.
Genet Couns
17
291-4
2006
Homo sapiens
Fernandes, RJ; Harkey, MA; Weis, M; Askew, JW; Eyre, DR
The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells.
Bone
40
1343-51
2007
Homo sapiens
Sipilä, L; Ruotsalainen, H; Sormunen, R; Baker, NL; Lamandé, SR; Vapola, M; Wang, C; Sado, Y; Aszodi, A; Myllylä, R
Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines.
J Biol Chem
282
33381-8
2007
Mus sp.
Ghosh, P; Saha, SK; Nandi, SS; Bhattacharya, S; Roy, SS
Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders.
Cell Physiol Biochem
20
887-98
2007
Rattus
YapicioÄŸlu, H; Ozcan, K; Arikan, O; Satar, M; Narli, N; Ozbek, MH
Bruck syndrome: osteogenesis imperfecta and arthrogryposis multiplex congenita.
Ann Trop Paediatr
29
159-62
2009
Homo sapiens
Simard, A; Di Giorgio, L; Amen, M; Westwood, A; Amendt, BA; Ryan, AK
The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis.
Dev Dyn
238
2459-70
2009
Spondias purpurea
Kosho, T; Miyake, N; Hatamochi, A; Takahashi, J; Kato, H; Miyahara, T; Igawa, Y; Yasui, H; Ishida, T; Ono, K; Kosuda, T; Inoue, A; Kohyama, M; Hattori, T; Ohashi, H; Nishimura, G; Kawamura, R; Wakui, K; Fukushima, Y; Matsumoto, N
A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations.
Am J Med Genet A
152A
1333-46
2010
Homo sapiens
Olucha, J; Lamb, AL
Mechanistic and structural studies of the N-hydroxylating flavoprotein monooxygenases.
Bioorg Chem
2011
Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus
Unoki, M; Masuda, A; Dohmae, N; Arita, K; Yoshimatsu, M; Iwai, Y; Fukui, Y; Ueda, K; Hamamoto, R; Shirakawa, M; Sasaki, H; Nakamura, Y
Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6).
J Biol Chem
288
6053-62
2013
Homo sapiens, Mus musculus
Eisinger-Mathason, TS; Zhang, M; Qiu, Q; Skuli, N; Nakazawa, MS; Karakasheva, T; Mucaj, V; Shay, JE; Stangenberg, L; Sadri, N; Puré, E; Yoon, SS; Kirsch, DG; Simon, MC
Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis.
Cancer Discov
2013
Homo sapiens, Mus musculus
Tsezou, A
Osteoarthritis year in review 2014: genetics and genomics.
Osteoarthritis Cartilage
22
2017-24
2014
Areas
Monthoux, C; de Brot, S; Jackson, M; Bleul, U; Walter, J
Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome.
BMC Vet Res
11
12
2015
Equus caballus
Huang, Y; Chen, D; Liu, C; Shen, W; Ruan, Y
Evolution and conservation of JmjC domain proteins in the green lineage.
Mol Genet Genomics
291
33-49
2016
Spermatophyta, plant
Belangero, PS; Leal, MF; Cohen, C; Figueiredo, EA; Smith, MC; Andreoli, CV; de Castro Pochini, A; Ejnisman, B; Cohen, M
Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability.
J Orthop Res
34
510-7
2016
Homo sapiens
Knipper, JA; Willenborg, S; Brinckmann, J; Bloch, W; Maaß, T; Wagener, R; Krieg, T; Sutherland, T; Munitz, A; Rothenberg, ME; Niehoff, A; Richardson, R; Hammerschmidt, M; Allen, JE; Eming, SA
Interleukin-4 Receptor ? Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
Immunity
43
803-16
2015
Homo sapiens, Mus sp.
Pankova, D; Chen, Y; Terajima, M; Schliekelman, MJ; Baird, BN; Fahrenholtz, M; Sun, L; Gill, BJ; Vadakkan, TJ; Kim, MP; Ahn, YH; Roybal, JD; Liu, X; Parra Cuentas, ER; Rodriguez, J; Wistuba, II; Creighton, CJ; Gibbons, DL; Hicks, JM; Dickinson, ME; West, JL; Grande-Allen, KJ; Hanash, SM; Yamauchi, M; Kurie, JM
Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.
Mol Cancer Res
14
287-95
2016
Homo sapiens, Mus sp.
Miller, TE; Liau, BB; Wallace, LC; Morton, AR; Xie, Q; Dixit, D; Factor, DC; Kim, LJY; Morrow, JJ; Wu, Q; Mack, SC; Hubert, CG; Gillespie, SM; Flavahan, WA; Hoffmann, T; Thummalapalli, R; Hemann, MT; Paddison, PJ; Horbinski, CM; Zuber, J; Scacheri, PC; Bernstein, BE; Tesar, PJ; Rich, JN
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Nature
547
355-359
2017
Mus musculus
He, JY; Wei, XH; Li, SJ; Liu, Y; Hu, HL; Li, ZZ; Kuang, XH; Wang, L; Shi, X; Yuan, ST; Sun, L
Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.
Cell Commun Signal
16
100
2018
Homo sapiens, clinical samples
Lewis, DM; Pruitt, H; Jain, N; Ciccaglione, M; McCaffery, JM; Xia, Z; Weber, K; Eisinger-Mathason, TSK; Gerecht, S
A feedback loop between hypoxia and matrix stress relaxation increases oxygen-axis migration and metastasis in sarcoma.
Cancer Res
2019
Homo sapiens
Oh, S; Shin, S; Janknecht, R
The small members of the JMJD protein family: Enzymatic jewels or jinxes?
Biochim Biophys Acta Rev Cancer
1871
406-418
2019
Homo sapiens
Peng, C; Cheng, Z; Zhu, X
[Wnt3a signaling pathway plays a role in neuropathic pain through epigenetic modification of JMJD6].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
44
386-391
2019
Rattus
Zhang, L; Xing, R; Huang, Z; Zhang, N; Zhang, L; Li, X; Wang, P
Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis.
Mediators Inflamm
2019
2165918
2019
Rattus
Tsiapalis, D; De Pieri, A; Spanoudes, K; Sallent, I; Kearns, S; Kelly, JL; Raghunath, M; Zeugolis, DI
The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents.
Biofabrication
12
025018
2020
Homo sapiens
Li, SS; Lian, YF; Huang, YL; Huang, YH; Xiao, J
Overexpressing PLOD family genes predict poor prognosis in gastric cancer.
J Cancer
11
121-131
2020
Homo sapiens
Yang, J; Chen, S; Yang, Y; Ma, X; Shao, B; Yang, S; Wei, Y; Wei, X
Jumonji domain-containing protein 6 protein and its role in cancer.
Cell Prolif
53
e12747
2020
Hepacivirus C, Foot-and-mouth disease virus
Saenz, D; Fiskus, W; Mill, CP; Perera, D; Manshouri, T; Lara, BH; Karkhanis, V; Sharma, S; Horrigan, SK; Bose, P; Kadia, TM; Masarova, L; DiNardo, CD; Borthakur, G; Khoury, J; Takahashi, K; Bhaskara, S; Lin, CY; Green, MR; Coarfa, C; Crews, CM; Verstovsek, S; Bhalla, KN
Mechanistic basis and efficacy of targeting ?-catenin-TCF7L2-JMJD6-MYC axis to overcome resistance to BET inhibitors.
Blood
2020
Homo sapiens
Li, J; Xing, J; Lu, F; Chang, W; Liang, N; Li, J; Wang, Y; Li, X; Zhao, X; Hou, R; Man, M; Yin, G; Li, X; Zhang, K
Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis.
Acta Derm Venereol
100
adv00122
2020
Homo sapiens, Enterovirus C
Liu, H; Lee, S; Zhang, Q; Chen, Z; Zhang, G
The potential underlying mechanism of the leukemia caused by MLL-fusion and potential treatments.
Mol Carcinog
59
839-851
2020
Transformation
Qadri, M; Jay, GD; Zhang, LX; Richendrfer, H; Schmidt, TA; Elsaid, KA
Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium.
Arthritis Res Ther
22
113
2020
Metazoa, Mus sp.
Yang, B; Zhao, Y; Wang, L; Zhao, Y; Wei, L; Chen, D; Chen, Z
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma.
Front Oncol
10
1695
2020
Homo sapiens
Li, F; Liu, H; Zhang, K; Xiao, DJ; Wang, C; Wang, YS
Adipose-derived stromal cells improve functional recovery after spinal cord injury through TGF-?1/Smad3/PLOD2 pathway activation.
Aging (Albany NY)
13
4370-4387
2021
animal, Rattus
Zhao, Y; Zhang, X; Yao, J
Comprehensive analysis of PLOD family members in low-grade gliomas using bioinformatics methods.
PLoS One
16
e0246097
2021
Homo sapiens
Lian, X; Bond, JS; Bharathy, N; Boudko, SP; Pokidysheva, E; Shern, JF; Lathara, M; Sasaki, T; Settelmeyer, T; Cleary, MM; Bajwa, A; Srinivasa, G; Hartley, CP; Bächinger, HP; Mansoor, A; Gultekin, SH; Berlow, NE; Keller, C
Defining the Extracellular Matrix of Rhabdomyosarcoma.
Front Oncol
11
601957
2021
Homo sapiens
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