Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | Homo sapiens | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
additional information | Homo sapiens | JMJD6 undergoes self-hydroxylation in the presence of Fe(II) and 2-oxoglutarate, in absence of substrate or in presence of substrates like U2AF65, resulting in production of (5S)<-hydroxylysine residues. JMJD6 in human cells is hydroxylated | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
additional information | JMJD6 undergoes self-hydroxylation in the presence of Fe(II) and 2-oxoglutarate, in absence of substrate or in presence of substrates like U2AF65, resulting in production of (5S)<-hydroxylysine residues. JMJD6 in human cells is hydroxylated | Homo sapiens | ? | - |
? | |
additional information | in absence of substrate JMJD6 catalyses turnover of 2-oxoglutarate to succinate | Homo sapiens | ? | - |
? | |
U2AF65 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jmjd6 | - |
Homo sapiens |
lysyl 5S-hydroxylase | - |
Homo sapiens |
lysyl hydroxylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the lysyl 5S-hydroxylase, JMJD6 acts on proteins involved in RNA splicin. JMJD6 in human cells is self-hydroxylated at Lys111JMJD6 and Lys167JMJD6 to give lysyl 5S-hydroxylase. Self-hydroxylation of JMJD6 may play a regulatory role in modulating the hydroxylation status of proteins involved in RNA splicing | Homo sapiens |