Cloned (Comment) | Organism |
---|---|
gene encoding isozyme LH1, DNA and amino acid sequence determination and analysis, quantitative expression analysis | Takifugu rubripes |
gene encoding isozyme LH2a, DNA and amino acid sequence determination and analysis, quantitative expression analysis | Takifugu rubripes |
gene encoding isozyme LH3, DNA and amino acid sequence determination and analysis, quantitative expression analysis | Takifugu rubripes |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | isozyme LH1 contains a signal peptide comprising residues Met1-Cys20 | Takifugu rubripes | - |
- |
additional information | isozyme LH2a contains a signal peptide comprising residues Met1-Ser19 | Takifugu rubripes | - |
- |
additional information | isozyme LH3 contains a signal peptide comprising residues Met1-Ala21 | Takifugu rubripes | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
84385 | - |
x * 84385, isozyme LH1, sequence calculation | Takifugu rubripes |
84558 | - |
x * 84558, isozyme LH3, sequence calculation | Takifugu rubripes |
85063 | - |
x * 85063, isozyme LH2a, sequence calculation | Takifugu rubripes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | Takifugu rubripes | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Takifugu rubripes | A5A6S1 | LH1 | - |
Takifugu rubripes | A5A6S2 | LH3 | - |
Takifugu rubripes | A5A6S3 | LH2a | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | isozyme LH1 contains 4 glycosylation sites | Takifugu rubripes |
glycoprotein | isozyme LH2a contains 7 glycosylation sites | Takifugu rubripes |
glycoprotein | isozyme LH3 contains 4 glycosylation sites | Takifugu rubripes |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Takifugu rubripes | - |
dorsal fin | - |
Takifugu rubripes | - |
embryo | tissue expression profiles of the three isozymes are different, quantitative expression analysis, in situ localizations, overview | Takifugu rubripes | - |
eye | - |
Takifugu rubripes | - |
gill | - |
Takifugu rubripes | - |
heart | - |
Takifugu rubripes | - |
intestine | - |
Takifugu rubripes | - |
kidney | head and body | Takifugu rubripes | - |
larva | in the hatching larvae, LH1 is expressed in the pectoral fin bud | Takifugu rubripes | - |
larva | in the hatching larvae, LH3 is expressed in the pectoral fin bud | Takifugu rubripes | - |
liver | - |
Takifugu rubripes | - |
muscle | ordinary and dark | Takifugu rubripes | - |
muscle | ordinary and dark, high expression of lysine hydroxylase 1 | Takifugu rubripes | - |
ovary | - |
Takifugu rubripes | - |
ovary | high expression of lysine hydroxylase 3 | Takifugu rubripes | - |
skin | - |
Takifugu rubripes | - |
spleen | - |
Takifugu rubripes | - |
swim bladder | - |
Takifugu rubripes | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Takifugu rubripes | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 84385, isozyme LH1, sequence calculation | Takifugu rubripes |
? | x * 84558, isozyme LH3, sequence calculation | Takifugu rubripes |
? | x * 85063, isozyme LH2a, sequence calculation | Takifugu rubripes |
Synonyms | Comment | Organism |
---|---|---|
LH1 | - |
Takifugu rubripes |
LH2a | - |
Takifugu rubripes |
LH3 | - |
Takifugu rubripes |
lysyl hydroxylase 1 | - |
Takifugu rubripes |
lysyl hydroxylase 2a | - |
Takifugu rubripes |
lysyl hydroxylase 3 | - |
Takifugu rubripes |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Takifugu rubripes | isozyme LH1, sequence calculation | - |
5.8 |
Takifugu rubripes | isozyme LH3, sequence calculation | - |
6.1 |
Takifugu rubripes | isozyme LH2a, sequence calculation | - |
6.2 |
General Information | Comment | Organism |
---|---|---|
physiological function | lysyl hydroxylase (LH) catalyzes the hydroxylation of lysine residues in collagens, and contributes to the formation of more stable collagen cross-links | Takifugu rubripes |