Cloned (Comment) | Organism |
---|---|
gene dPlod or CG6199, maps to cytological position 68B1 on the left arm of the third chromosome, DNA and amino acid sequence determination and analysis, sequence comparisons | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Drosophila melanogaster | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | Drosophila melanogaster | collagen type IV | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene dPlod, or CG6199, encoding the only lysyl hydroxylase of the organism | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fat body | - |
Drosophila melanogaster | - |
hemocyte | - |
Drosophila melanogaster | - |
additional information | developmental expression patterns of dPlod RNA and protein during embryogenesis,overview. dPlod is highly expressed in type-IV collagen-producing cells, particularly the hemocytes and fat body | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
L-lysine-[procollagen] + 2-oxoglutarate + O2 | collagen type IV | Drosophila melanogaster | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LH3 | - |
Drosophila melanogaster |
lysyl hydroxylase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
evolution | LH3 belongs to the lysyl hydroxylase family of enzymes that has important roles in the biosynthesis of collagen | Drosophila melanogaster |
physiological function | dPlod is required for type-IV collagen secretion from hemocytes and fat body | Drosophila melanogaster |