Information on EC 1.1.1.27 - L-lactate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
1.1.1.27
-
RECOMMENDED NAME
GeneOntology No.
L-lactate dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Bifidobacterium shunt
-
Biosynthesis of secondary metabolites
-
Cysteine and methionine metabolism
-
glucose and xylose degradation
-
Glycolysis / Gluconeogenesis
-
heterolactic fermentation
-
Metabolic pathways
-
Microbial metabolism in diverse environments
-
Propanoate metabolism
-
pyruvate fermentation to lactate
-
Pyruvate metabolism
-
SYSTEMATIC NAME
IUBMB Comments
(S)-lactate:NAD+ oxidoreductase
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
A4-LDH
Q0GND8
-
anaerobic lactate dehydrogenase
Q0GND9
-
anaerobic lactate dehydrogenase
Q0GND8
-
BbLDH
Q7Z0X7
-
dehydrogenase, lactate
-
-
-
-
eLDHA
B7XH73
-
eLDHB
C6L1K8
-
Epsilon crystallin
-
-
-
-
epsilon-crystallin
-
-
-
-
H4-L-lactate dehydrogenase
-
-
heart LDH
-
-
Immunogenic protein p36
-
-
-
-
L(+)-nLDH
-
-
-
-
L-(+)-lactate dehydrogenase
-
-
-
-
L-(+)-lactate dehydrogenase
B1A4R6
-
L-(+)-lactate dehydrogenase
Thermoanaerobacter ethanolicus JW200
B1A4R6
-
-
L-lactate dehydrogenase B
-
-
L-lactic acid dehydrogenase
-
-
-
-
L-lactic dehydrogenase
-
-
-
-
L-LDH
-
-
-
-
L-LDH
Thermoanaerobacter ethanolicus JW200
B1A4R6
-
-
lactate dehydrogenase
-
-
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
Bacillus subtilis BS35
-
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
Pontonia pinnophylax
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
Rhizopus delemar RA 99-880
-
-
-
lactate dehydrogenase
Rhizopus oryzae NRRL 395
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
-
-
lactate dehydrogenase
P90613, Q27797
-
lactate dehydrogenase A
B7XH73
-
lactate dehydrogenase B
C6L1K8
-
lactate dehydrogenase NAD-dependent
-
-
-
-
lactic acid dehydrogenase
-
-
-
-
lactic dehydrogenase
-
-
-
-
LctD
Aggregatibacter actinomycetemcomitans HK1651 and VT1169
-
-
-
LDH
-
-
-
-
LDH
Bacillus subtilis BS35
-
-
-
LDH
-
-
LDH
Mus musculus AKR
-
-
-
LDH
Pontonia pinnophylax
-
-
LDH-1
-
-
LDH-2
-
-
LDH-3
-
-
LDH-4
-
-
LDH-5
-
-
LDH-A
-
-
LDH-A
-
-
LDH-A
Mus musculus AKR
-
-
-
LDH-A4
Pontonia pinnophylax
-
-
LDH1
P90613
-
LDH2
Q27797
-
LdhA
Rhizopus oryzae NRRL 395
-
-
LDHB
Rhizopus delemar RA 99-880
-
-
-
LDHB
Rhizopus oryzae NRRL 395
-
-
muscle LDH
-
-
NAD-lactate dehydrogenase
-
-
-
-
nitric oxideinducible l-lactate dehydrogenase
-
-
proteins, specific or class, anoxic stress response, p34
-
-
-
-
TeLdhL
Thermoanaerobacter ethanolicus JW200
B1A4R6
-
-
mLDH
-
-
additional information
-
lactate dehydrogenase is a member of the 2-hydroxyacid oxidoreductase family
CAS REGISTRY NUMBER
COMMENTARY
9001-60-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Agama stellio stellio
-
-
-
Manually annotated by BRENDA team
a Gram-negative opportunistic pathogen found exclusively in the mammalian oral cavity in the space between the gums and the teeth known as the gingival crevice, gene AA02769
-
-
Manually annotated by BRENDA team
Aggregatibacter actinomycetemcomitans HK1651 and VT1169
a Gram-negative opportunistic pathogen found exclusively in the mammalian oral cavity in the space between the gums and the teeth known as the gingival crevice, gene AA02769
-
-
Manually annotated by BRENDA team
Galapagos marine iguana, gene ldh-a
UniProt
Manually annotated by BRENDA team
epsilon-crystallin
-
-
Manually annotated by BRENDA team
strain 90
SwissProt
Manually annotated by BRENDA team
Bacillus megaterium 90
strain 90
SwissProt
Manually annotated by BRENDA team
strain BS35, gene ldh
-
-
Manually annotated by BRENDA team
Bacillus subtilis BS35
strain BS35, gene ldh
-
-
Manually annotated by BRENDA team
calf
-
-
Manually annotated by BRENDA team
gene ldhA encoding L-lactate dehydrogenase
-
-
Manually annotated by BRENDA team
Cyclodina aenea
-
-
-
Manually annotated by BRENDA team
genes ldh-1 and ldh-2
-
-
Manually annotated by BRENDA team
eLDHA; isozymes LDH A, encoded by gene LDHA
UniProt
Manually annotated by BRENDA team
eLDHB, fragment; isozymes LDH B, encoded by gene LDHB
UniProt
Manually annotated by BRENDA team
several isozymes, overview
-
-
Manually annotated by BRENDA team
Hoplodactylus chrysosireticus
-
-
-
Manually annotated by BRENDA team
individuals from Man Island and mainland Wellington
-
-
Manually annotated by BRENDA team
common iguana
UniProt
Manually annotated by BRENDA team
ssp. casein
-
-
Manually annotated by BRENDA team
Lactobacillus mesenteroides
-
-
-
Manually annotated by BRENDA team
strain SK007
-
-
Manually annotated by BRENDA team
strain SK007
-
-
Manually annotated by BRENDA team
strain 760
-
-
Manually annotated by BRENDA team
strain MG1363, genes ldh and ldhB
Uniprot
Manually annotated by BRENDA team
Lactococcus lactis 760
strain 760
-
-
Manually annotated by BRENDA team
Lactococcus lactis MG1363
strain MG1363, genes ldh and ldhB
Uniprot
Manually annotated by BRENDA team
Molinema dessetae
-
-
-
Manually annotated by BRENDA team
strain AKR
-
-
Manually annotated by BRENDA team
Mus musculus AKR
strain AKR
-
-
Manually annotated by BRENDA team
no activity in Rubus idaeus
leaf
-
-
Manually annotated by BRENDA team
no activity in Taraxacum officinale
leaf
-
-
Manually annotated by BRENDA team
no activity in Zea mays
leaf
-
-
Manually annotated by BRENDA team
several isozymes
-
-
Manually annotated by BRENDA team
several isozymes
-
-
Manually annotated by BRENDA team
several isozymes
-
-
Manually annotated by BRENDA team
several isozymes
-
-
Manually annotated by BRENDA team
Pontonia pinnophylax
inhabiting the mantle cavity of host Pinna nobilis
-
-
Manually annotated by BRENDA team
female Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
male adult Wistar rats
-
-
Manually annotated by BRENDA team
Rhizopus delemar RA 99-880
-
-
-
Manually annotated by BRENDA team
strains 99-880 and NRRL 395, genes ldhB and ldhA
-
-
Manually annotated by BRENDA team
Rhizopus oryzae NRRL 395
-
-
-
Manually annotated by BRENDA team
gene ldh-1
-
-
Manually annotated by BRENDA team
Streptococcus mitior
-
-
-
Manually annotated by BRENDA team
fructose 1,6-diphosphate dependent enzyme
-
-
Manually annotated by BRENDA team
gene ldhL
B1A4R6
UniProt
Manually annotated by BRENDA team
Thermoanaerobacter ethanolicus JW200
gene ldhL
B1A4R6
UniProt
Manually annotated by BRENDA team
Thermus caldophilus GK24
GK24
-
-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
14
46
Q0GND9
in vivo temperature
14
46
Q0GND8
in vivo temperature
20
70
-
90% of maximal activity at 50C and 50% at 60C
37
60
-
37C: about 85% of maximal activity, 60C: about 90% of maximal activity
37
65
-
optimal temperatures for the reduction and oxidation reactions are 37-65C and 40-50C, respectively
PDB
SCOP
CATH
ORGANISM
Bacillus cereus (strain ATCC 14579 / DSM 31)
Bacillus cereus (strain ATCC 14579 / DSM 31)
Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Plasmodium berghei (strain Anka)
Plasmodium falciparum (isolate 3D7)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Plasmodium falciparum (isolate CDC / Honduras)
Staphylococcus aureus (strain COL)
Staphylococcus aureus (strain COL)
Staphylococcus aureus (strain COL)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)