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Results 1 - 10 of 23 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762A defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV -, 761771
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762A mutation inhibits both 2'-O and G-N-7 methylations -, 761770
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762A mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L -, 762505
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762E mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type 762505
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762G mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type 762505
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375D1762N mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type 762505
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375E1833Q defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV -, 761771
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375E1833Q mutation inhibits both 2'-O and G-N-7 methylations -, 761770
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375E1833Q mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L -, 762505
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.375G1670A mice inoculated with G1670A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence 761771
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