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Literature summary for 2.1.1.375 extracted from

  • Ma, Y.; Wei, Y.; Zhang, X.; Zhang, Y.; Cai, H.; Zhu, Y.; Shilo, K.; Oglesbee, M.; Krakowka, S.; Whelan, S.P.; Li, J.
    mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo (2014), J. Virol., 88, 2913-2926 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D1762A defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV vesicular stomatitis Indiana virus
E1833Q defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV vesicular stomatitis Indiana virus
G1670A mice inoculated with G1670A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence vesicular stomatitis Indiana virus
G1672A mice inoculated with G1672A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence vesicular stomatitis Indiana virus
G4A mutant virus is completely defective in both G-N-7 and 2'-O methylation, exhibits low virulence in mice despite productive viral replication is not detected in lung and brain vesicular stomatitis Indiana virus
K1651A defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV vesicular stomatitis Indiana virus

Organism

Organism UniProt Comment Textmining
vesicular stomatitis Indiana virus P03523
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vesicular stomatitis Indiana virus San Juan P03523
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