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Information on EC 2.1.1.375 - NNS virus cap methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.375 NNS virus cap methyltransferase
IUBMB Comments
The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyses two successive methylations. In higher eukaryotes the two methylations occur in the reverse order and are catalysed by two different enzymes (cf. EC 2.1.1.56, mRNA (guanine-N7)-methyltransferase, and EC 2.1.1.57, methyltransferase cap1) that do not required a specific motif.
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Word Map
  • 2.1.1.375
  • stomatitis
  • vesicular
  • rna-dependent
  • polyadenylation
  • non-segmented
  • unconventional
  • negative-strand
  • gdp
  • guanylyltransferase
  • rhabdoviruses
  • methylase
  • parainfluenza
  • nucleocapsids
  • mononegavirales
  • polyribonucleotidyltransferase
  • ppprna
  • rhabdoviridae
  • phosphoprotein
  • guanine-n-7
  • prntase
  • stock
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
vsv l, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = 2 S-adenosyl-L-homocysteine + m7G(5')pppAmACA-[mRNA]
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overall reaction
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S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5')pppAmACA-[mRNA]
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + G(5')pppAmACA-[mRNA] = S-adenosyl-L-homocysteine + m7G(5')pppAmACA-[mRNA]
show the reaction diagram
(1b)
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