EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
6.3.4.2 | -999 |
- |
more |
xanthine and related compounds inhibit CTPS activity with IC50 = 0.16-0.58 mM. The presence of an 8-oxo function enhances the inhibition to IC50 = 0.060-0.121 mM. Raising the pH from 8.0 to 8.5 results in slightly increased inhibition of NH3-dependent CTP formation by the xanthines |
702613 |
6.3.4.2 | 0.04 |
- |
CTP |
wild-type, pH 8.1, 37°C |
715549 |
6.3.4.2 | 0.042 |
- |
CTP |
wild-type, pH 8.1, 37°C |
715549 |
6.3.4.2 | 0.045 |
- |
CTP |
mutant S571A, pH 8.1, 37°C |
715549 |
6.3.4.2 | 0.05 |
- |
CTP |
IC50: 0.05 mM |
649000 |
6.3.4.2 | 0.057 |
- |
CTP |
C-terminal deletion mutant, pH 8.1, 37°C |
715549 |
6.3.4.2 | 0.06 |
- |
uric acid |
pH 8.0, Gln-dependent CTP formation |
702613 |
6.3.4.2 | 0.063 |
- |
3,7-dimethyluric acid |
pH 8.0, Gln-dependent CTP formation |
702613 |
6.3.4.2 | 0.067 |
- |
1,3,7-trimethyluric acid |
pH 8.0, Gln-dependent CTP formation |
702613 |
6.3.4.2 | 0.07 |
- |
1,3,7-trimethyluric acid |
pH 8.0, NH3-dependent CTP formation |
702613 |