EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.224 | more |
Cfr methylates A2503 of 23S rRNA at C8 and C2, while RlmN only performs a C2 methylation using the same mechanism of function |
Mammaliicoccus sciuri |
? |
- |
- |
2.1.1.224 | more |
in vitro assays with Escherichia coli RNA |
Clostridioides difficile |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Bacillus amyloliquefaciens |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Enterococcus faecalis |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Paenibacillus lautus |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Clostridioides difficile |
? |
- |
- |
2.1.1.224 | more |
the enzyme employs a [4Fe-4S] cluster to supply the requisite electron for reductive cleavage of SAM, usually to L-methionine and a 5'-deoxyadenosyl 5'-radical. SAM is the source of both the 5'-deoxyadenosyl 5'-radical and the appended methyl group |
Staphylococcus aureus |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Bacillus amyloliquefaciens DSM-7 |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Paenibacillus lautus Y412MC10 |
? |
- |
- |
2.1.1.224 | more |
kinetic analysis of methylation of a 155mer rRNA substrate by Cfr enzymes under limiting and under excess substrate conditions initiated with a protein-based reductant, substrate sequence, overview |
Enterococcus faecalis TX0645 |
? |
- |
- |