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Search term: NT2/D1 cell
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1.1.1.41
isocitrate dehydrogenase (NAD+)
NT2/D1 cell
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741407
3.4.19.12
ubiquitinyl hydrolase 1
NT2/D1 cell
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667234
3.4.19.12
ubiquitinyl hydrolase 1
NT2/D1 cell
down regulation of UCHL1 is detected immediately after oxygen-glucose deprivation treatment and its expression is subsequently restored and increased 6 h after oxygen-glucose deprivation treatment as well as during reoxygenation. A lower level of UCHL1 is detected only in apoptotic cells with severe loss of mitochondrial membrane potential. Down-regulation of endogenous UCHL1 by antisense cDNA in mouse N2a neuroblastoma cells increased the cellยs sensitivity to oxygen-glucose deprivation. This down-regulation of endogenous UCHL1 leads to the accumulation of p27, suggesting that UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions
667234
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