Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress | ? | - |
? | |
additional information | Homo sapiens | UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NT2/D1 cell | - |
Homo sapiens | - |
NT2/D1 cell | down regulation of UCHL1 is detected immediately after oxygen-glucose deprivation treatment and its expression is subsequently restored and increased 6 h after oxygen-glucose deprivation treatment as well as during reoxygenation. A lower level of UCHL1 is detected only in apoptotic cells with severe loss of mitochondrial membrane potential. Down-regulation of endogenous UCHL1 by antisense cDNA in mouse N2a neuroblastoma cells increased the cellยs sensitivity to oxygen-glucose deprivation. This down-regulation of endogenous UCHL1 leads to the accumulation of p27, suggesting that UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress | Homo sapiens | ? | - |
? | |
additional information | UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase-L1 | - |
Homo sapiens |
UCHL1 | - |
Homo sapiens |