EC Number |
General Information |
Reference |
---|
2.7.1.68 | evolution |
PIP5K sequences and inferred apicomplexan PIP5K gene tree, overview |
-, 723333 |
2.7.1.68 | malfunction |
downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments |
759692 |
2.7.1.68 | malfunction |
enzyme knockdown affects the recruitment of talin and focal adhesion kinase to the plasma membrane |
738165 |
2.7.1.68 | malfunction |
enzyme knockdown impairs Akt activation in response to both FBS and ECM protein stimulation |
738651 |
2.7.1.68 | malfunction |
enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B |
721782 |
2.7.1.68 | malfunction |
enzyme mutants exhibit shorter root hairs than the wild type and remained responsive to phosphate deficiency in root hair elongation |
739315 |
2.7.1.68 | malfunction |
enzyme silencing impairs CD28-mediated IL-8 and IL-2 transcriptional activation |
738787 |
2.7.1.68 | malfunction |
isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid |
759034 |
2.7.1.68 | malfunction |
isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide |
722815 |
2.7.1.68 | malfunction |
isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells |
722815 |