Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BV-2 cell | - |
Mus musculus | - |
microglia | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-phosphate 5-kinase alpha | isoform | Mus musculus |
PIP5Kalpha | isoform | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | treatment of BV-2 microglial cells with lipoteichoic acid increases isoform PIP5Kalpha expression in BV-2 and primary microglial cells, but not in primary cultures from Toll-like receptor 2-deficient mice | up |
General Information | Comment | Organism |
---|---|---|
malfunction | isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid | Mus musculus |
physiological function | phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid | Mus musculus |