Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
PIP5K3 is involved in localizing 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate to the elongating root hair apex and is a key regulator of the machinery that initiates and promotes root hair tip growth.
-
r
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ATP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + dipalmitoyl phosphatidylinositol 4-phosphate
ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
-
-
-
-
?
ATP + phosphatidylinositol 3-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
?
ATP + phosphatidylinsositol 3,4-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
weak activity
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
weak activity
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme is induced by water stress and abscisic acid. The enzyme is involved in water-stress signal transduction
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme may be under control of phosphatidic acid level in membranes
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme is stimulated during temperature-induced morphogenesis, i.e. switch to the hyphal growth form
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
preferred substrate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
preferred substrate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
641824, 641825, 641834, 641840, 660641, 661660, 672961, 673185, 675959, 721706, 722723, 738090, 738199, 738288, 738599, 738651, 738787, 738790, 738794, 738912, 759168, 759475, 760179 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
641839, 641846, 641847, 641848, 641853, 660641, 660875, 661660, 662494, 662546, 672374, 673185, 673332, 673679, 675019, 676789, 722784, 723653, 737960, 738165, 739178, 759034 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme plays an essential role during neurite retraction in response to a number of diverse stimuli
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, especially produced by isozyme beta, is required for constitutive endocytosis of transferrin receptors via clathrin-coated pits, and probably also for the regulation thereof
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme activity is regulated by Arf6 activation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
641773, 641822, 641824, 641828, 641829, 641830, 641831, 641833, 641850, 641852, 660641, 660965, 675006, 676808, 738176 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme from liver membrane is possible regulated by a G-protein
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme form PIPKIgamma may cooperate with synaptojanin in the regulation of actin and synaptic vesicle traffic
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme activity is regulated by cAMP levels. This regulation may be critical in the initiation of cell growth for which 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate seems to be necessary
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the MSS4 gene product functions in regulation of actin-binding proteins through generation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from 1-phosphatidyl-1D-myo-inositol 4-phosphate in or near the plasma membrane
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate, which is a precursor of diacylglycerol and inositol 1,4,5-triphosphate and is also involved in regulation of actin cytoskeleton remodeling and membrane traffic. The enzyme is regulated by casein kinase Cki1
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
0.05 mM GTP is 2fold more active than ATP with type II enzyme. 0.05 mM GTP is 5fold more active than ATP with the type I enzyme
-
-
?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
no activity
-
-
?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
50% of the activity with ATP
-
-
?
additional information
?
-
GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.
-
-
?
additional information
?
-
-
GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.
-
-
?
additional information
?
-
PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.
-
-
?
additional information
?
-
-
PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.
-
-
?
additional information
?
-
Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
-
?
additional information
?
-
-
Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization
-
-
?
additional information
?
-
-
phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor
-
-
?
additional information
?
-
-
endosome-bound phosphatidylinositol 4-phosphate 5-kinase homolog PIP5K-like 1 recruits phosphatidylinositol 4-phosphate 5-kinases to intracellular compartments and interacts with them in cells
-
-
-
additional information
?
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview
-
-
?
additional information
?
-
-
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
splicing form a of the isozyme gamma is inactive, splicing form c is involved in maintenance of some neuronal cellular processes
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
PIP5K3 is involved in localizing 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate to the elongating root hair apex and is a key regulator of the machinery that initiates and promotes root hair tip growth.
-
r
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme is induced by water stress and abscisic acid. The enzyme is involved in water-stress signal transduction
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme may be under control of phosphatidic acid level in membranes
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme is stimulated during temperature-induced morphogenesis, i.e. switch to the hyphal growth form
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
721706, 722723, 738090, 738199, 738288, 738599, 738651, 738787, 738790, 738794, 738912, 759168, 759475, 760179 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme plays an essential role during neurite retraction in response to a number of diverse stimuli
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, especially produced by isozyme beta, is required for constitutive endocytosis of transferrin receptors via clathrin-coated pits, and probably also for the regulation thereof
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme activity is regulated by Arf6 activation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme from liver membrane is possible regulated by a G-protein
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme form PIPKIgamma may cooperate with synaptojanin in the regulation of actin and synaptic vesicle traffic
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme activity is regulated by cAMP levels. This regulation may be critical in the initiation of cell growth for which 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate seems to be necessary
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the MSS4 gene product functions in regulation of actin-binding proteins through generation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from 1-phosphatidyl-1D-myo-inositol 4-phosphate in or near the plasma membrane
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate, which is a precursor of diacylglycerol and inositol 1,4,5-triphosphate and is also involved in regulation of actin cytoskeleton remodeling and membrane traffic. The enzyme is regulated by casein kinase Cki1
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
additional information
?
-
GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.
-
-
?
additional information
?
-
-
GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.
-
-
?
additional information
?
-
PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.
-
-
?
additional information
?
-
-
PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.
-
-
?
additional information
?
-
Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
-
?
additional information
?
-
-
Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization
-
-
?
additional information
?
-
-
phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor
-
-
?
additional information
?
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview
-
-
?
additional information
?
-
-
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
splicing form a of the isozyme gamma is inactive, splicing form c is involved in maintenance of some neuronal cellular processes
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Moritz, A.; Westerman, J.; De Graan, P.N.E.; Wirtz, K.W.A.
Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes
Methods Enzymol.
209
202-211
1992
Bos taurus
brenda
Sommarin, M.; Sandelius, A.S.
Phosphatidylinositol and phosphatidylinositolphosphate kinases in plant plasma membranes
Biochim. Biophys. Acta
958
268-278
1988
Triticum aestivum
-
brenda
Cooper, P.H.; Hawthorne, J.N.
Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization
Biochem. J.
160
97-105
1976
Rattus norvegicus
brenda
Kai, M.; Salway, J.G.; Hawthorne, J.N.
The diphosphoinositide kinase of rat brain
Biochem. J.
106
791-801
1968
Rattus norvegicus
brenda
Moritz, A.; De Graan, P.N.E.; Ekhart, P.F.; Gispen, W.H.; Wirtz, K.W.A.
Purification of a phosphatidylinositol 4-phosphate kinase from bovine brain membranes
J. Neurochem.
54
351-354
1990
Bos taurus
brenda
Smith, P.M.; Wreggett, K.A.; Irvine, R.F.
The phosphatidylinositol 4-phosphate kinase of rat brain and human platelets
Biochem. Soc. Trans.
14
1145-1146
1986
Homo sapiens, Rattus norvegicus
-
brenda
Bazenet, C.E.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes
Methods Enzymol.
209
189-202
1992
Homo sapiens
brenda
Van Rooijen, L.A.A.; Rossowska, M.; Bazan, N.G.
Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate
Biochem. Biophys. Res. Commun.
126
150-155
1985
Bos taurus
brenda
Kato, H.; Uno, I.; Ishikawa, T.; Takenawa, T.
Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae
J. Biol. Chem.
264
3116-3121
1989
Saccharomyces cerevisiae
brenda
Lundberg, G.A.; Sundler, R.; Jergil, B.
Activation of phosphatidylinositol-4-phosphate kinase in rat liver plasma membranes by polyamines
Biochim. Biophys. Acta
922
1-7
1987
Rattus norvegicus
brenda
Cochet, C.; Chambaz, E.M.
Catalytic properties of a purified phosphatidylinositol-4-phosphate kinase from rat brain
Biochem. J.
237
25-31
1986
Rattus norvegicus
brenda
Lundberg, G.A.; Jergil, B.; Sundler, R.
Phosphatidylinositol-4-phosphate kinase from rat brain. Activation by polyamines and inhibition by phosphatidylinositol 4,5-bisphosphate
Eur. J. Biochem.
161
257-262
1986
Rattus norvegicus
brenda
Urumow, T.; Wieland, O.H.
Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein
Biochim. Biophys. Acta
1052
152-158
1990
Rattus norvegicus
brenda
Husebye, E.S.; Flatmark, T.
Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions
Biochim. Biophys. Acta
1010
250-257
1989
Bos taurus
brenda
Van Dongen, C.J.; Zwiers, H.; Gispen, W.H.
Purification and partial characterization of the phosphatidylinositol 4-phosphate kinase from rat brain
Biochem. J.
223
197-203
1984
Rattus norvegicus
brenda
Ling, L.E.; Schulz, J.T.; Cantley, L.C.
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells
J. Biol. Chem.
264
5080-5088
1989
Homo sapiens
brenda
Moritz, A.; De Graan, P.N.E.; Gispen, W.H.; Wirtz, K.W.A.
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase
J. Biol. Chem.
267
7207-7210
1992
Bos taurus
brenda
Galiano, F.J.; Ulug, E.T.; Davis, J.N.
Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway
J. Cell. Biochem.
85
131-145
2002
Mus musculus
brenda
Zhang, X.; Loijens, J.C.; Boronenkov, I.V.; Parker, G.J.; Norris, F.A.; Chen, J.; Thum, O.; Prestwich, G.D.; Majerus, P.W.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
J. Biol. Chem.
272
17756-17761
1997
Homo sapiens
brenda
Cutler, N.S.; Heitman, J.; Cardenas, M.E.
STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae
J. Biol. Chem.
272
27671-27677
1997
Saccharomyces cerevisiae
brenda
Loijens, J.C.; Anderson, R.A.
Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
J. Biol. Chem.
271
32937-32943
1996
Bos taurus
brenda
Homma, K.; Terui, S.; Minemura, M.; Qadota, H.; Anraku, Y.; Kanaho, Y.; Ohya, Y.
Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis
J. Biol. Chem.
273
15779-15786
1998
Saccharomyces cerevisiae
brenda
Vancurova, I.; Choi, J.H.; Lin, H.; Kuret, J.; Vancura, A.
Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I
J. Biol. Chem.
274
1147-1155
1999
Schizosaccharomyces pombe
brenda
Mikami, K.; Katagiri, T.; Iuchi, S.; Yamaguchi-Shinozaki, K.; Shinozaki, K.
A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana
Plant J.
15
563-568
1998
Arabidopsis thaliana
brenda
Barbieri, M.A.; Heath, C.M.; Peters, E.M.; Wells, A.; Davis, J.N.; Stahl, P.D.
Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis
J. Biol. Chem.
276
47212-47216
2001
Mus musculus
brenda
Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis
J. Biol. Chem.
277
43849-43857
2002
Mus musculus
brenda
Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
J. Biol. Chem.
277
17226-17230
2002
Mus musculus
brenda
Kwok, F.; Humpage, A.; Cheng, C.H.K.
Phosphatidylinositol phosphate 5-kinase: purification and inhibition studies
Prep. Biochem. Biotechnol.
26
1-19
1996
Ovis aries
brenda
Jones, D.H.; Morris, J.B.; Morgan, C.P.; Kondo, H.; Irvine, R.F.; Cockcroft, S.
Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment
J. Biol. Chem.
275
13962-13966
2000
Rattus norvegicus
brenda
Hairfield, M.L.; Westwater, C.; Dolan, J.W.
Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans
Microbiology
148
1737-1746
2002
Candida albicans
brenda
Wenk, M.R.; Pellegrini, L.; Klenchin, V.A.; Di Paolo, G.; Chang, S.; Daniell, L.; Arioka, M.; Martin, T.F.; De Camilli, P.
PIP kinase Ig is the major PI(4,5)P2 synthesizing enzyme at the synapse
Neuron
32
79-88
2001
Rattus norvegicus
brenda
Tolias, K.F.; Hartwig, J.H.; Ishihara, H.; Shibasaki, Y.; Cantley, L.C.; Carpenter, C.L.
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
Curr. Biol.
10
153-156
2000
Mus musculus
brenda
Oude Weernink, P.A.; Schulte, P.; Guo, Y.; Wetzel, J.; Amano, M.; Kaibuchi, K.; Haverland, S.; Voss, M.; Schmidt, M.; Mayr, G.W.; Jakobs, K.H.
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase
J. Biol. Chem.
275
10168-10174
2000
Homo sapiens
brenda
Park, S.J.; Itoh, T.; Takenawa, T.
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli
J. Biol. Chem.
276
4781-4787
2001
Mus musculus
brenda
van Horck, F.P.; Lavazais, E.; Eickholt, B.J.; Moolenaar, W.H.; Divecha, N.
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling
Curr. Biol.
12
241-245
2002
Mus musculus
brenda
Kanaho, Y.; Miyazaki, H.; Yamazaki, M.
Activation of PI(4)P 5-kinase by small G proteins
Adv. Enzyme Regul.
43
107-119
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.
Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma
Biochem. Biophys. Res. Commun.
319
456-463
2004
Mus musculus
brenda
Giudici, M.L.; Emson, P.C.; Irvine, R.F.
A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma
Biochem. J.
379
489-496
2004
Rattus norvegicus
brenda
Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
Regulation and cellular roles of phosphoinositide 5-kinases
Eur. J. Pharmacol.
500
87-99
2004
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
brenda
Perera, I.Y.; Davis, A.J.; Galanopoulou, D.; Im, Y.J.; Boss, W.F.
Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases
FEBS Lett.
579
3427-3432
2005
Arabidopsis thaliana (Q56YP2), Arabidopsis thaliana (Q9LMN1), Homo sapiens (Q99755), Homo sapiens
brenda
Padron, D.; Wang, Y.J.; Yamamoto, M.; Yin, H.; Roth, M.G.
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
J. Cell Biol.
162
693-701
2003
Mus musculus
brenda
Wong, K.W.; Isberg, R.R.
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake
J. Exp. Med.
198
603-614
2003
Mus musculus
brenda
Perez-Mansilla, B.; Ha, V.L.; Justin, N.; Wilkins, A.J.; Carpenter, C.L.; Thomas, G.M.
The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
Biochim. Biophys. Acta
1761
1429-1442
2006
Mus musculus
brenda
Akiyama, C.; Shinozaki-Narikawa, N.; Kitazawa, T.; Hamakubo, T.; Kodama, T.; Shibasaki, Y.
Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells
Cell Biol. Int.
29
514-520
2005
Homo sapiens
brenda
Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
Curr. Biol.
16
1850-1856
2006
Homo sapiens, Mus musculus
brenda
Nakano-Kobayashi, A.; Yamazaki, M.; Unoki, T.; Hongu, T.; Murata, C.; Taguchi, R.; Katada, T.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis
EMBO J.
26
1105-1116
2007
Mus musculus
brenda
Xu, X.; Guo, H.; Wycuff, D.L.; Lee, M.
Role of phosphatidylinositol-4-phosphate 5 kinase (ppk-1) in ovulation of Caenorhabditis elegans
Exp. Cell Res.
313
2465-2475
2007
Caenorhabditis elegans
brenda
Giudici, M.L.; Lee, K.; Lim, R.; Irvine, R.F.
The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
FEBS Lett.
580
6933-6937
2006
Mus musculus
brenda
Cabezas, A.; Pattni, K.; Stenmark, H.
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene
371
34-41
2006
Homo sapiens (Q9Y2I7)
brenda
Ling, K.H.; Loo, S.S.; Rosli, R.; Shamsudin, M.N.; Mohamed, R.; Wan, K.L.
In silico identification and characterization of a putative phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gene in Eimeria tenella
In Silico Biol.
7
115-121
2007
Eimeria tenella (A1YQB1), Eimeria tenella
brenda
Kobayashi, T.; Takematsu, H.; Yamaji, T.; Hiramoto, S.; Kozutsumi, Y.
Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
J. Biol. Chem.
280
18087-18094
2005
Saccharomyces cerevisiae
brenda
Deng, L.; Sugiura, R.; Ohta, K.; Tada, K.; Suzuki, M.; Hirata, M.; Nakamura, S.; Shuntoh, H.; Kuno, T.
Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway
J. Biol. Chem.
280
27561-27568
2005
Schizosaccharomyces pombe
brenda
Powner, D.J.; Payne, R.M.; Pettitt, T.R.; Giudici, M.L.; Irvine, R.F.; Wakelam, M.J.
Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b
J. Cell Sci.
118
2975-2986
2005
Rattus norvegicus
brenda
Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.
Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate
J. Cell. Biochem.
100
112-128
2007
Mus musculus
brenda
Kisseleva, M.; Feng, Y.; Ward, M.; Song, C.; Anderson, R.A.; Longmore, G.D.
The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha
Mol. Cell. Biol.
25
3956-3966
2005
Homo sapiens
brenda
Lou, Y.; Gou, J.Y.; Xue, H.W.
PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth
Plant Cell
19
163-181
2007
Arabidopsis thaliana (Q8L850), Arabidopsis thaliana
brenda
Gong, L.W.; Di Paolo, G.; Diaz, E.; Cestra, G.; Diaz, M.E.; Lindau, M.; De Camilli, P.; Toomre, D.
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion
Proc. Natl. Acad. Sci. USA
102
5204-5209
2005
Mus musculus
brenda
Krauss, M.; Kukhtina, V.; Pechstein, A.; Haucke, V.
Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes
Proc. Natl. Acad. Sci. USA
103
11934-11939
2006
Rattus norvegicus
brenda
Kusano, H.; Testerink, C.; Vermeer, J.E.; Tsuge, T.; Shimada, H.; Oka, A.; Munnik, T.; Aoyama, T.
The arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator of root hair tip growth
Plant Cell
20
367-380
2008
Arabidopsis thaliana (O48709), Arabidopsis thaliana
brenda
Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.
Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults
Dev. Biol.
313
384-397
2008
Caenorhabditis elegans (O01759), Caenorhabditis elegans
brenda
Weixel, K.M.; Edinger, R.S.; Kester, L.; Guerriero, C.J.; Wang, H.; Fang, L.; Kleyman, T.R.; Welling, P.A.; Weisz, O.A.; Johnson, J.P.
Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells
J. Biol. Chem.
282
36534-36542
2007
Mus musculus
brenda
Nelson, C.D.; Kovacs, J.J.; Nobles, K.N.; Whalen, E.J.; Lefkowitz, R.J.
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor
J. Biol. Chem.
283
21093-21101
2008
Homo sapiens
brenda
Lacalle, R.A.; Peregil, R.M.; Albar, J.P.; Merino, E.; Martinez-A, C.; Merida, I.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
J. Cell Biol.
179
1539-1553
2007
Homo sapiens
brenda
Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mol. Biol. Cell
18
5069-5080
2007
Homo sapiens, Mus musculus
brenda
Stenzel, I.; Ischebeck, T.; Koenig, S.; Ho?ubowska, A.; Sporysz, M.; Hause, B.; Heilmann, I.
The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana
Plant Cell
20
124-141
2008
Arabidopsis thaliana
brenda
Xia, Y.; Irvine, R.F.; Giudici, M.L.
Phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, a new splice variant found in rodents and humans
Biochem. Biophys. Res. Commun.
411
416-420
2011
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Gallicchio, M.A.; Bach, L.A.
Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma
Biochim. Biophys. Acta
1803
919-930
2010
Homo sapiens, Sus scrofa
brenda
Hasegawa, H.; Noguchi, J.; Yamashita, M.; Okada, R.; Sugimoto, R.; Furuya, M.; Unoki, T.; Funakoshi, Y.; Baba, T.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis
Biol. Reprod.
86:136
1-12
2012
Mus musculus
brenda
Sakurai, A.; Jian, X.; Lee, C.J.; Manavski, Y.; Chavakis, E.; Donaldson, J.; Randazzo, P.A.; Gutkind, J.S.
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein
J. Biol. Chem.
286
34335-34345
2011
Homo sapiens
brenda
Shulga, Y.V.; Anderson, R.A.; Topham, M.K.; Epand, R.M.
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator
J. Biol. Chem.
287
35953-35963
2012
Mus musculus
brenda
Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location
J. Biol. Chem.
288
5645-5659
2013
Homo sapiens, Mus musculus (P70182)
brenda
Goh, M.Y.; Pan, M.Z.; Blake, D.P.; Wan, K.L.; Song, B.K.
Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison
Parasitol. Res.
108
611-620
2011
Eimeria maxima (C8BX38), Eimeria maxima, Eimeria maxima Weybridge (C8BX38)
brenda
Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
Proc. Natl. Acad. Sci. USA
109
1725-1730
2012
Mus musculus
brenda
Sakagami, H.; Katsumata, O.; Hara, Y.; Tamaki, H.; Fukaya, M.
Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses
Brain Res.
1586
23-33
2014
Mus musculus
brenda
Sun, Y.; Hedman, A.C.; Tan, X.; Schill, N.J.; Anderson, R.A.
Endosomal type Igamma PIP 5-kinase controls EGF receptor lysosomal sorting
Dev. Cell
25
144-155
2013
Homo sapiens
brenda
Choi, S.; Thapa, N.; Hedman, A.C.; Li, Z.; Sacks, D.B.; Anderson, R.A.
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
EMBO J.
32
2617-2630
2013
Homo sapiens (O60331)
brenda
Hara, Y.; Fukaya, M.; Tamaki, H.; Sakagami, H.
Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex
Eur. J. Neurosci.
38
2659-2671
2013
Mus musculus
brenda
Liu, T.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
Exp. Mol. Med.
45
e16
2013
Rattus norvegicus
brenda
Lacalle, R.A.; de Karam, J.C.; Martinez-Munoz, L.; Artetxe, I.; Peregil, R.M.; Sot, J.; Rojas, A.M.; Goni, F.M.; Mellado, M.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity
FASEB J.
29
2371-2385
2015
Homo sapiens
brenda
Porciello, N.; Kunkl, M.; Viola, A.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation
Front. Immunol.
7
186
2016
Homo sapiens
brenda
Thapa, N.; Choi, S.; Hedman, A.; Tan, X.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igammai2 in association with Src controls anchorage-independent growth of tumor cells
J. Biol. Chem.
288
34707-34718
2013
Homo sapiens
brenda
Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth
J. Biol. Chem.
290
18843-18854
2015
Homo sapiens
brenda
Chakrabarti, R.; Sanyal, S.; Ghosh, A.; Bhar, K.; Das, C.; Siddhanta, A.
Phosphatidylinositol-4-phosphate 5-kinase 1alpha modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha
J. Biol. Chem.
290
20893-20903
2015
Homo sapiens (Q99755)
brenda
Muscolini, M.; Camperio, C.; Capuano, C.; Caristi, S.; Piccolella, E.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha activation critically contributes to CD28-dependent signaling responses
J. Immunol.
190
5279-5286
2013
Homo sapiens
brenda
Muscolini, M.; Camperio, C.; Porciello, N.; Caristi, S.; Capuano, C.; Viola, A.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions
J. Immunol.
194
1323-1333
2015
Homo sapiens
brenda
Kallikourdis, M.; Trovato, A.E.; Roselli, G.; Muscolini, M.; Porciello, N.; Tuosto, L.; Viola, A.
Phosphatidylinositol 4-phosphate 5-kinase beta controls recruitment of lipid rafts into the immunological synapse
J. Immunol.
196
1955-1963
2016
Homo sapiens
brenda
Kubo, T.; Ding, W.G.; Toyoda, F.; Fujii, Y.; Omatsu-Kanbe, M.; Matsuura, H.
Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation
J. Pharmacol. Sci.
127
127-134
2015
Homo sapiens
brenda
Yamazaki, M.; Yamauchi, Y.; Goshima, Y.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase beta regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons
Neurosci. Lett.
547
59-64
2013
Mus musculus
brenda
Wada, Y.; Kusano, H.; Tsuge, T.; Aoyama, T.
Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana
Plant J.
81
426-437
2015
Arabidopsis thaliana
brenda
Ugalde, J.M.; Rodriguez-Furlan, C.; Rycke, R.D.; Norambuena, L.; Friml, J.; Leon, G.; Tejos, R.
Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development
Plant Sci.
250
10-19
2016
Arabidopsis thaliana
brenda
Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Cell. Signal.
38
159-170
2017
Mus musculus
brenda
Wu, P.F.; Bhore, N.; Lee, Y.L.; Chou, J.Y.; Chen, Y.W.; Wu, P.Y.; Hsu, W.M.; Lee, H.; Huang, Y.S.; Lu, P.J.; Liao, Y.F.
Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein
FASEB J.
34
12127-12146
2020
Homo sapiens
brenda
Sharma, S.; Bhattacharya, S.; Bhattacharya, A.
PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica
FEBS J.
286
2216-2234
2019
Entamoeba histolytica (C4LSF7), Entamoeba histolytica HM1:IMSS (C4LSF7)
brenda
Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.
Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation
J. Anat.
234
502-514
2019
Mus musculus (O70161), Mus musculus (P70181), Mus musculus (P70182)
brenda
Sun, M.; Cai, J.; Anderson, R.A.; Sun, Y.
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls the ubiquitination and degradation of the tumor suppressor mitogen-inducible gene 6
J. Biol. Chem.
291
21461-21473
2016
Homo sapiens
brenda
De La Cruz, L.; Traynor-Kaplan, A.; Vivas, O.; Hille, B.; Jensen, J.
Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4
J. Cell Sci.
133
jcs233254
2020
Homo sapiens (O14986), Homo sapiens (O60331)
brenda
Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.
Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane
J. Virol.
94
e00189-20
2020
Homo sapiens (O60331), Homo sapiens (Q99755)
brenda
Gerth, K.; Lin, F.; Daamen, F.; Menzel, W.; Heinrich, F.; Heilmann, M.
Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins
Plant J.
92
862-878
2017
Arabidopsis thaliana
brenda
Yang, Y.; Park, M.; Maekawa, M.; Fairn, G.D.
Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins
Sci. Rep.
9
14789
2019
Homo sapiens
brenda