EC Number   |
General Information |
Reference |
|---|
    1.14.14.24 | malfunction |
compared with noncarriers, carriers of 4 risk alleles of rs10741657 have lowest concentrations and smallest increases in 25-hydroxy-vitamin D concentrations after 4 UVB treatments and largest decreases in 25-hydroxy-vitamin D concentrations after 6-months of consumption of vitamin D3fortified bread and milk. Common genetic variants rs10741657 and rs10766197 in vitamin D25-hydroxylase (CYP2R1) predict 25-hydroxy-vitamin D concentrations |
735419 |
| 1.14.14.24 | malfunction |
enzyme-deficient Cyp2r1-/- mice show greater than 50% reduction in serum 25-hydroxyvitamin D3 level, while the 1alpha,25-dihydroxyvitamin D3 level in the serum remains unchanged. A double knockout of Cyp2r1 and Cyp27a1, the enzyme responsible for the 1alpha-hydroxylation step, maintain a similar circulating level of 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3 |
-, 737160 |
| 1.14.14.24 | metabolism |
the cross talk from the bone to the testis of the vitamin D 25-hydroxylase CYP2R1 involves osteocalcin, which is produced by the osteoblasts and stimulates the production of testosterone by the Leydig cells through its putative receptor GPRC6A, a cation-sensing G-protein-coupled receptor. Action of osteocalcin on CYP2R1 expression and 25-hydroxyvitamin D production in a mouse Leydig cell line MA-10 |
736019 |
| 1.14.14.24 | metabolism |
the microsomal enzyme CYP2R1 catalyzes C-25 hydroxylation of vitamin D3 to an active vitamin D receptor ligand in the liver and other organs |
759328 |
| 1.14.14.24 | physiological function |
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. A second enzyme is another contributor to this important step in vitamin D activation |
-, 737160 |
| 1.14.14.24 | physiological function |
CYP2R1 is a physiologically important vitamin D 25-hydroxylase. Vitamin D3 is initially converted to 25(OH)D3 in the liver, and then 25(OH)D 3 is converted to a functionally active form, namely 1alpha,25(OH)2D3, in the kidney. 1alpha,25(OH)2D3 plays essential roles in calcium and phosphate homeostasis, cell differentiation and immunology. Metabolic activation of vitamin D3 is performed by the hepatic vitamin D3 25-hydroxylase microsomal CYP2R1, and mitochondrial 1alpha-hydroxylase CYP27A1 |
735593 |
| 1.14.14.24 | physiological function |
expression of CYP2R1 in HEK 293 cells leads to the transcriptional activation of the vitamin D receptor when either vitamin D2 or D3 is added to the medium. Co-expression of CYP2R1 with vitamin D 1-hydroxylase CYP27B1 elicits additive activation of vitamin D3, whereas co-expression with vitamin D 24-hydroxylase CYP24A1 causes inactivation |
717767 |
| 1.14.14.24 | physiological function |
in male rats, hypophysectomy reduces body weight by 40% and liver weight by 50%. 25-Hydroxylase activity is reduced by 64%, 24-hydroxylase activity is reduced by 52%, and hepatic microsomal CYP2C11 mRNA is decreased by 73% compared with the values of sham-operated animals |
717071 |
| 1.14.14.24 | physiological function |
the absence of either of the two key hydroxylases, i.e., 25-hydroxylase and 1alpha-hydroxylase, neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis in a mice model |
718332 |
| 1.14.14.24 | physiological function |
the microsomal vitamin D 25-hydroxylase plays an important role in converting dietary vitamin D to active metabolite, 25-(OH)D3. 1,25(OH)2D3 regulates CYP2R1 gene expression in oral squamous cell carcinoma tumor cells |
736222 |
