Cloned (Comment) | Organism |
---|---|
expression in insect cells | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0026 | - |
1alpha-hydroxyvitamin D3 | pH 7.4, 37°C, 25-hydroxylation | Rattus norvegicus | |
0.0042 | - |
1alpha-hydroxyvitamin D2 | pH 7.4, 37°C, 24-hydroxylation | Rattus norvegicus | |
0.0051 | - |
1alpha-hydroxyvitamin D3 | pH 7.4, 37°C, 26-hydroxylation | Rattus norvegicus | |
0.0058 | - |
1alpha-hydroxyvitamin D3 | pH 7.4, 37°C, 24-hydroxylation | Rattus norvegicus | |
0.018 | - |
1alpha-hydroxyvitamin D2 | pH 7.4, 37°C, 25-hydroxylation | Rattus norvegicus | |
0.018 | - |
1alpha-hydroxyvitamin D2 | pH 7.4, 37°C, 26-hydroxylation | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P08683 | male-specific hepatic microsomal vitamin D 25-hydroxlase CYP2C11 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,25-dihydroxyvitamin D2 + O2 + [reduced NADPH-hemoprotein reductase] + H+ | - |
Rattus norvegicus | 1alpha,25,26-trihydroxyvitamin D2 + [oxidized NADPHhemoprotein reductase] + H2O | - |
? | |
1alpha,25-dihydroxyvitamin D3 + O2 + [reduced NADPH-hemoprotein reductase] + H+ | - |
Rattus norvegicus | 1alpha,25,26-trihydroxyvitamin D3 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1alpha-hydroxyvitamin D2 + O2 + NADPH + H+ | - |
Rattus norvegicus | 1alpha,25-dihydroxyvitamin D2 + NADP+ + H2O | - |
? | |
1alpha-hydroxyvitamin D3 + O2 + NADPH + H+ | - |
Rattus norvegicus | 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
additional information | the descending order of 25-hydroxylation by CYP2C11 is 1-hydroxyvitamin D3, 1-hydroxyvitamin D2, vitamin D, vitamin D3. 24-Hydroxylation of 1alpha-hydroxyvitamin D3 is very low and does not occur with 1-alpha-hydroxyvitamin D2 | Rattus norvegicus | ? | - |
? | |
vitamin D2 + O2 + NADPH + H+ | - |
Rattus norvegicus | 25-hydroxyvitamin D2 + NADP+ + H2O | - |
? | |
vitamin D3 + O2 + NADPH + H+ | - |
Rattus norvegicus | 25-hydroxyvitamin D3 + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP2C11 | - |
Rattus norvegicus |
Cytochrome P450 2C11 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | in male rats, hepatic microsomal CYP2C11 mRNA is decreased by 73% upon hypophysectomy | down |
General Information | Comment | Organism |
---|---|---|
physiological function | in male rats, hypophysectomy reduces body weight by 40% and liver weight by 50%. 25-Hydroxylase activity is reduced by 64%, 24-hydroxylase activity is reduced by 52%, and hepatic microsomal CYP2C11 mRNA is decreased by 73% compared with the values of sham-operated animals | Rattus norvegicus |