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Literature summary for 1.14.14.24 extracted from

  • Sundaram, K.; Sambandam, Y.; Tsuruga, E.; Wagner, C.L.; Reddy, S.V.
    1alpha,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells (2014), Horm. Cancer, 5, 90-97.
    View publication on PubMed
Search for more literature for 1.14.14.24

Application

Application Comment Organism
medicine vitamin D analogus can be potential therapeutic agents to control oral squamous cell carcinoma tumor cell tumor progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP2R1, real-time RT-PCR enzyme expression analysis, transient expression of hCYP2R1 promoter (-2 kb)-luciferase reporter plasmid, stimulation with 1,25(OH)2D3 causes a 4.3fold increase in promoter activity. In addition, 1,25-(OH)2D3 significantly increased c-Fos, p-c-Jun expression, and c-Jun N-terminal kinase activity in these cells. AP-1 is a downstream effector of 1,25(OH)2D3 signaling to modulate CYP2R1 gene expression in OSCC tumor cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calciol + O2 + [reduced NADPH-hemoprotein reductase] Homo sapiens enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6VVX0 gene CYP2R1
-

Source Tissue

Source Tissue Comment Organism Textmining
oral squamous cell carcinoma cell high levels of CYP2R1 expression compared to healthy adjacent tissue Homo sapiens
-
SCC-1 cell
-
 Homo sapiens
-
SCC-11B cell
-
 Homo sapiens
-
SCC-14A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calciol + O2 + [reduced NADPH-hemoprotein reductase] enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position Homo sapiens calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP2R1
-
 Homo sapiens
cytochrome P450 2R1
-
 Homo sapiens
vitamin D 25-hydroxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 1alpha,25-dihydroxyvitamin D3 increases CYP2R1 gene and and vitamin D receptor mRNA expression in human oral squamous cell carcinoma tumor cells. JNK inhibitor suppresses 1,25 (OH)2D3 stimulation of hCYP2R1 gene promoter activity compared to unstimulated cells up

General Information

General Information Comment Organism
physiological function the microsomal vitamin D 25-hydroxylase plays an important role in converting dietary vitamin D to active metabolite, 25-(OH)D3. 1,25(OH)2D3 regulates CYP2R1 gene expression in oral squamous cell carcinoma tumor cells Homo sapiens