EC Number   |
General Information |
Reference |
|---|
   1.1.1.153 | malfunction |
enzyme inhibition reduces pain hypersensitivity in a mouse model of joint inflammation |
760458 |
| 1.1.1.153 | malfunction |
RNAi-mediated knockdown of SPR expression significantly reduces native ornithine decarboxylase enzyme activity and impedes neuroblastoma cell proliferation |
740231 |
| 1.1.1.153 | malfunction |
tetrahydrobiopterin deficiencies are implicated in neuronal disorders. Drosophile melanogastersloss-of-function enzyme mutants are resonsibel for hyposensitivityy to oxidative stress, enzyme activity and tetrahydrobiopterin levels in the mutants are significantly reduced compared to wild-type, while levels of phosphorylated Akt and total Akt protein are increased in the enzyme mutants |
741390 |
| 1.1.1.153 | malfunction |
the knockdown of SPR leads to a significant and consistent decrease in cellular proliferation of neuroblastoma cells |
728158 |
| 1.1.1.153 | metabolism |
sepiapterin reductase (SPR) catalyzes the final steps of tetrahydrobiopterin (BH4) biosynthesis |
739887 |
| 1.1.1.153 | metabolism |
sepiapterin reductase is a key enzyme in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin |
741390 |
| 1.1.1.153 | metabolism |
the enzyme plays an important role in the biosynthesis of tetrahydrobiopterin |
761589 |
| 1.1.1.153 | more |
computational docking of inhibitor sulfasalazine into sepiapterin reductase using crystal structure of human SPR in complex with NADP+ in a hexameric assembly, PDB ID 1Z6Z |
740231 |
| 1.1.1.153 | more |
enzyme three-dimensional structure molecular modeling and docking using crystal structures of SPR, PDB IDs 1SEP, 1NAS, 4HWK, 4J7U, and 4J7X, and the structure of menadione, PDB ID 2QR2, overview |
740892 |
| 1.1.1.153 | physiological function |
high SPR expression is significantly correlated to unfavorable neuroblastoma characteristics like high age at diagnosis, MYCN oncogene amplification, and high INSS disease stage. Sulfasalazine inhibits the growth of neuroblatoma cells in vitro, presumably due to the inhibition of sepiapterin reductase |
740231 |
