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Literature summary for 1.1.1.153 extracted from
- Sepiapterin reductase Characteristics and role in diseases (2020), J. Cell. Mol. Med., 24, 9495-9506 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme can regulate chronic pain and is a target for the development of analgesics | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-Carboxypterin | - |
Homo sapiens |  |
| acetic acid | - |
Homo sapiens | |
| dicoumarol | - |
Homo sapiens | |
| Ethacrynic acid | - |
Homo sapiens | |
| indomethacin | - |
Homo sapiens | |
| Isosepiapterin | - |
Homo sapiens | |
| mesalamine | - |
Homo sapiens | |
| N-acetylserotonin | - |
Homo sapiens | |
| N-acetylsulfapyridine | - |
Homo sapiens | |
| n-butyric acid | - |
Homo sapiens | |
| propionic acid | - |
Homo sapiens | |
| QM385 | - |
Homo sapiens | |
| rutin | - |
Homo sapiens | |
| SPRi3 | - |
Homo sapiens | |
| sulfamethoxazole | - |
Homo sapiens | |
| sulfapyridine | - |
Homo sapiens | |
| sulfasalazine | - |
Homo sapiens | |
| sulfathiazole | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+ | Homo sapiens | - |
tetrahydrobiopterin + NADP+ | - |
? | |
| sepiapterin + NADPH + H+ | Homo sapiens | - |
7,8-dihydrobiopterin + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P35270 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BE(2)M17 cell | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| cerebral cortex | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+ | - |
Homo sapiens | tetrahydrobiopterin + NADP+ | - |
? | |
| sepiapterin + NADPH + H+ | - |
Homo sapiens | 7,8-dihydrobiopterin + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SPR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000149 | - |
pH and temperature not specified in the publication | Homo sapiens | QM385 | |
| 0.000014 | - |
pH and temperature not specified in the publication | Homo sapiens | sulfathiazole | |
| 0.000019 | - |
pH and temperature not specified in the publication | Homo sapiens | sulfamethoxazole | |
| 0.0000235 | - |
pH and temperature not specified in the publication | Homo sapiens | sulfasalazine | |
| 0.000074 | - |
pH and temperature not specified in the publication | Homo sapiens | SPRi3 | |
| 0.00029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-acetylsulfapyridine | |
| 0.00037 | - |
pH and temperature not specified in the publication | Homo sapiens | mesalamine | |
| 0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | sulfapyridine | |
| 0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | dicoumarol | |
| 0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | N-acetylserotonin | |
| 0.03 | - |
pH and temperature not specified in the publication | Homo sapiens | Ethacrynic acid | |
| 0.03 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-Carboxypterin | |
| 0.032 | - |
pH and temperature not specified in the publication | Homo sapiens | n-butyric acid | |
| 0.045 | - |
pH and temperature not specified in the publication | Homo sapiens | propionic acid | |
| 0.06 | - |
pH and temperature not specified in the publication | Homo sapiens | indomethacin | |
| 0.06 | - |
pH and temperature not specified in the publication | Homo sapiens | rutin | |
| 0.065 | - |
pH and temperature not specified in the publication | Homo sapiens | Isosepiapterin | |
| 0.45 | - |
pH and temperature not specified in the publication | Homo sapiens | acetic acid | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme mRNA level increases in the brains of Parkinson's disease patients | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme plays an important role in the biosynthesis of tetrahydrobiopterin | Homo sapiens |
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