EC Number   |
Reaction |
Reference |
|---|
    3.5.4.1 | cytosine + H2O = uracil + NH3 |
- |
- |
| 3.5.4.1 | cytosine + H2O = uracil + NH3 |
active site architecture and substrate binding, catalytic mechanism |
656128 |
| 3.5.4.1 | cytosine + H2O = uracil + NH3 |
E64 side-chain carboxyl group acts as proton shuttle between the Zn-bound water molecule and cytosine. In course of reaction, cytosine reorients to favor nucleophilic attack by a Zn-bound hydroxide. F114 may be important for reactant binding and product release |
670004 |
| 3.5.4.1 | cytosine + H2O = uracil + NH3 |
substrate binding involves a significant conformational change that sequesters the reaction complex from solvent, active site architecture and substrate binding, catalytic mechanism |
656497 |
