EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.21.5 | more |
Staphylococcus aureus staphylocoagluase activates proenzyme without proteolysis. Staphylocoagulase-enzyme complex forms a dimer that binds substrate fibrinogen with dissociation constant of 8-34 nM |
669440 |
| 3.4.21.5 | proteolytic modification |
activation of prothrombin by snake venom from Oxyuranus scutellatus |
653981 |
| 3.4.21.5 | proteolytic modification |
activation of prothrombin through cleavage by tissue factor, can be blocked with a TF-neutralizing antibody and TF-siRNA |
717955 |
| 3.4.21.5 | proteolytic modification |
activation of recombinant wild-type and mutant DELTAK9 prothrombins by Taipan snake venom treatment |
652519 |
| 3.4.21.5 | proteolytic modification |
activation of the recombinant wild-type and mutant enzymes by snake venom enzyme ecarin |
652512 |
| 3.4.21.5 | proteolytic modification |
active thrombin is generated from thrombinogen by proteolytic cleavage |
717199 |
| 3.4.21.5 | proteolytic modification |
prothrombin requires activation by proteolytic cleavage, clevage sites are R155, R271, and R286, in vitro activation by Taipan snake venom |
683292 |
| 3.4.21.5 | proteolytic modification |
recombinant mutant prothrombins are activated through proteolytic cleavage using crude venom from Echis carinatus and 1:100 dilution of venom from Agkistrodon acutus in the presence of 10 mM benzamidine and 10 mM CaCl2 |
717789 |
| 3.4.21.5 | proteolytic modification |
the zymogen can be activated via different pathways, the pre2 pathway: cleavage at Arg271 and prethrombin 2 of prothrombin by the membrane-bound factor Xa alone, the meizo pathway: factor Va directs prothrombin activation by factor Xa through the meizothrombin pathway, characterized by initial cleavage at Arg320, the prothrombinase complex is responsible for activation, overview |
683637 |
| 3.4.21.5 | proteolytic modification |
thrombinogen activation to thrombin by factor Va |
717429 |
