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Literature summary for 3.4.21.5 extracted from

  • Kerk, N.; Strozyk, E.A.; Poeppelmann, B.; Schneider, S.W.
    The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells (2010), J. Invest. Dermatol., 130, 2259-2268.
    View publication on PubMed
Search for more literature for 3.4.21.5

Inhibitors

Inhibitors Comment Organism Structure
enoxaparin a low-molecular-weight heparin, an effective inhibitor of thrombin generation and thrombin activity in plasma Homo sapiens
tinzaparin a low-molecular-weight heparin, an effective inhibitor of thrombin generation and thrombin activity in plasma Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
intracellular
-
 Homo sapiens 5622
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation of prothrombin through cleavage by tissue factor, can be blocked with a TF-neutralizing antibody and TF-siRNA Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
MV3 cell a metastatic melanoma cell line Homo sapiens
-
WM-9 cell a metastatic melanoma cell line Homo sapiens
-

General Information

General Information Comment Organism
physiological function mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cell and in vitro mechanisms by which two human metastatic melanoma cell lines, MV3 and WM9, transform the vascular endothelium into a prothrombotic activated state, protective effect of heparins, overview. Low-molecular-weight heparins inhibit melanoma cell-triggered thrombin generation Homo sapiens