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Literature summary for 3.4.21.5 extracted from

  • Bae, J.S.; Yang, L.; Manithody, C.; Rezaie, A.R.
    The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells (2007), Blood, 110, 3909-3916.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.5

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in EA.hy926 cells, co-expression with activated protein C Homo sapiens

Protein Variants

Protein Variants Comment Organism
R155A/R271A/R286A site-directed mutagenesis, the mutation of enzyme's proteolytic cleavage sites hinder the activation of the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the ligand occupancy of endothelial protein C receptor by caveolin-1 switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells, overview ?
-
 ?
protease-activated receptor 1 + H2O Homo sapiens endothelial protein C receptor-dependent cleavage of PAR-1 on vascular endothelial cells, the enzyme exhibts anti-inflammatory activity ?
-
 ?
protein C zymogen + H2O Homo sapiens on vascular endothelial cells activated protein C + propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification prothrombin requires activation by proteolytic cleavage, clevage sites are R155, R271, and R286, in vitro activation by Taipan snake venom Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell vascular, cell surface Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the ligand occupancy of endothelial protein C receptor by caveolin-1 switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells, overview Homo sapiens ?
-
 ?
protease-activated receptor 1 + H2O endothelial protein C receptor-dependent cleavage of PAR-1 on vascular endothelial cells, the enzyme exhibts anti-inflammatory activity Homo sapiens ?
-
 ?
protease-activated receptor 1 + H2O endothelial protein C receptor-dependent cleavage of PAR-1 Homo sapiens ?
-
 ?
protein C zymogen + H2O
-
 Homo sapiens activated protein C + propeptide
-
 ?
protein C zymogen + H2O on vascular endothelial cells Homo sapiens activated protein C + propeptide
-
 ?