EC Number   |
Application |
Reference |
|---|
   5.6.2.2 | analysis |
use of triple-helical DNA structures for targeting enzyme-mediated cleavage to DNA specific sequences and use of drug-triplex-forming oligonucleotides to investgate enzyme mechanism |
682162 |
| 5.6.2.2 | diagnostics |
topoisomerase IIbeta acts as an additional biomarker in DNA repair and aging in cerebellar granule neurons, overview |
716955 |
| 5.6.2.2 | drug development |
class of anthracyclines seems to be a good source for selection of anticancer drugs directed toward cancer cells with the developed multidrug resistance attributed to the presence of altered DNA topoisomerase II |
701451 |
| 5.6.2.2 | drug development |
enzyme is target of several useful anticancer drugs |
692660 |
| 5.6.2.2 | drug development |
type IIalpha DNA topoisomerase is among the most important clinical drug targets for the treatment of cancer |
728231 |
| 5.6.2.2 | medicine |
a candidate procedure for the study to topoisomerase II in patient-derived blood samples |
3884 |
| 5.6.2.2 | medicine |
both isoforms IIalpha and IIbeta are present in pre-integration complexes of HIV-1. Enzyme inhibitors azalactone ferrocene, thiomorpholide amido methyl ferrocene and ruthenium benzene amino pyridine show singificant anti-HIV-1 activity at nanomolar concentrations in Sup-T1 cells |
677807 |
| 5.6.2.2 | medicine |
catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression |
748798 |
| 5.6.2.2 | medicine |
mouse skin carcinogenesis model, the incidence of VP-16-induced melanomas in the skin of 7,12-dimethylbenz[a]anthracene-treated mice is found to be significantly higher in wild-type than in skin-specific isoform 2beta-knockout mice. Etoposide-induced DNA sequence rearrangements and double-strand breaks are found to be isoform 2beta-dependent and preventable by cotreatment with a proteasome inhibitor. The cytotoxicity of etoposide in wild-type cells is mainly dependent on enzyme isoform 2alpha |
682545 |
| 5.6.2.2 | medicine |
the enzyme is a target for cancer chemotherapy |
662925 |
