Literature summary for 5.6.2.2 extracted from

Azarova, A.M.; Lyu, Y.L.; Lin, C.P.; Tsai, Y.C.; Lau, J.Y.; Wang, J.C.; Liu, L.F.
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies (2007), Proc. Natl. Acad. Sci. USA, 104, 11014-11019.

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Application

Application	Comment	Organism
medicine	mouse skin carcinogenesis model, the incidence of VP-16-induced melanomas in the skin of 7,12-dimethylbenz[a]anthracene-treated mice is found to be significantly higher in wild-type than in skin-specific isoform 2beta-knockout mice. Etoposide-induced DNA sequence rearrangements and double-strand breaks are found to be isoform 2beta-dependent and preventable by cotreatment with a proteasome inhibitor. The cytotoxicity of etoposide in wild-type cells is mainly dependent on enzyme isoform 2alpha	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
etoposide	cytotoxicity of inhibitor is mainly dependent on enzyme isoform 2alpha	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	mouse skin carcinogenesis model, isoforms 2alpha, 2beta	-

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Release 2023.1 (January 2023)