EC Number   |
Application |
Reference |
|---|
   2.4.1.221 | diagnostics |
enzyme POFUT1 may serve as a diagnostic marker and a therapeutic target for oral squamous cell carcinoma cells |
736272 |
| 2.4.1.221 | diagnostics |
Pofut1 overexpression clinically correlates with the unfavorable survival and high disease recurrence in hepatocellular carcinoma |
735621 |
| 2.4.1.221 | drug development |
POFUT1 is a potential target for cancers driven by Notch1 mutations |
759308 |
| 2.4.1.221 | medicine |
an aberrant activated Pofut1-Notch pathway is involved in hepatocellular carcinoma progression, and blockage of this pathway can be a promising strategy for the therapy of hepatocellular carcinomas |
735621 |
| 2.4.1.221 | molecular biology |
engineering of an O-fucosylation system in yeast provides a powerful tool for producing proteins with homogenous carbohydrate chains. Such proteins can be used for the analysis of substrate specificity and the production of antibodies that recognize O-glycosylated EGF domains |
692530 |
| 2.4.1.221 | molecular biology |
O-fucosylation is dispensable for many Notch signaling events during Drosophila development |
691483 |
