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Literature summary for 2.4.1.221 extracted from
- Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling (2008), BMC Biol., 6, 1-10.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | O-fucosylation is dispensable for many Notch signaling events during Drosophila development | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R254A | expression of a mutant, Ofut1R245A, lacking fucosyltransferase activity, rescues the requirement for Ofut1 in embryonic neurogenesis. Lack of requirement for O-fucosylation is further supported by the absence of embryonic phenotypes in Gmd mutants, which lack all forms of fucosylation. Requirements for O-fucose during imaginal development are evaluated by characterizing clones of cells expressing only Ofut1R245A. These clones phenocopy fringe mutant clones, indicating that the absence of O-fucose is functionally equivalent to the absence of elongated O-fucose | Drosophila melanogaster |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| O-fucosyltransferase 1 | - |
Drosophila melanogaster |
| OFUTI | - |
Drosophila melanogaster |
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