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Literature summary for 2.4.1.221 extracted from

  • Yokota, S.; Ogawara, K.; Kimura, R.; Shimizu, F.; Baba, T.; Minakawa, Y.; Higo, M.; Kasamatsu, A.; Endo-Sakamoto, Y.; Shiiba, M.; Tanzawa, H.; Uzawa, K.
    Protein O-fucosyltransferase 1: a potential diagnostic marker and therapeutic target for human oral cancer (2013), Int. J. Oncol., 43, 1864-1870.
    View publication on PubMed
Search for more literature for 2.4.1.221

Application

Application Comment Organism
diagnostics enzyme POFUT1 may serve as a diagnostic marker and a therapeutic target for oral squamous cell carcinoma cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative reverse tran­scriptase PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H488 gene POFUT1
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
Ho-1-u-1 cell
-
 Homo sapiens
-
HSC-2 cell
-
 Homo sapiens
-
HSC-3 cell
-
 Homo sapiens
-
HSC-4 cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
KOSC2 cell
-
 Homo sapiens
-
oral squamous cell carcinoma cell oral squamous cell carcinoma cell-derived cell lines and primary oral squamous cell carcinoma cells, increased enzyme expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
Pofut1
-
 Homo sapiens
protein O-fucosyltransferase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens POFUT1 mRNA expression is upregulated in oral squamous cell carcinoma cells up

General Information

General Information Comment Organism
malfunction cell proliferation of POFUT1 knock­down cells is significantly inhibited compared with that of control cells, phenotypes, overview Homo sapiens
physiological function the enzyme adds O-fucose through O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cellular surface and secreted proteins. ENzyme POFUT1 expres­sion can contribute to cancer progression Homo sapiens