EC Number   |
Application |
Reference |
|---|
   2.1.1.77 | biotechnology |
useful in biotechnical applications |
485610 |
| 2.1.1.77 | medicine |
a cloned source of this enzyme should be useful in the identification of cellular substrates and for quantitation and localization of isoaspartyl sites in purified proteins, including recombinant proteins used as pharmaceuticals |
485606 |
| 2.1.1.77 | medicine |
aging research, accumulation of damaged proteins have detrimental effects over the human lifespan |
485613 |
| 2.1.1.77 | medicine |
L-isoaspartyl residue formation in extracellular matrix proteins such as type -I collagen could play an important role in reducing cell migration. PIMT could be a therapeutic tool to restore normal cell migration in pathological conditions where cell motility is crucial |
658659 |
| 2.1.1.77 | medicine |
mutations in the PCMT1 gene are associated with premature ovarian failure |
703773 |
| 2.1.1.77 | medicine |
PCMT1 is associated with the type 1 diabetes in groups defined by other risk genes (SUMO4 and HLA) |
706709 |
| 2.1.1.77 | medicine |
results show that PIMT expression is up-regulated by GSK-3 inhibition and beta-catenin stabilization upon treatments with lithium and valproic acid suggesting a possible therapeutic role for PIMT in certain brain diseases including epilepsy |
689203 |
| 2.1.1.77 | medicine |
strong enzyme expression is a predictive marker of poor prognosis for surgically resected lung adenocarcinoma |
756902 |
| 2.1.1.77 | molecular biology |
betaine administration of rats prevents the ethanol-induced accumulation of isoaspartyl-containing proteins in the liver by restoring the PIMT-catalyzed protein repair reaction through normalizing the hepatocellular SAM:SAH ratios |
688134 |
| 2.1.1.77 | nutrition |
enzymatic detection of L-isoaspartyl residues in food proteins |
485608 |
