Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.77 extracted from

  • Pyun, J.A.; Kang, H.; Lee, S.K.; Kim, M.H.; Kwack, K.
    Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure (2009), Fertil. Steril., 91, 1362-1365.
    View publication on PubMed
Search for more literature for 2.1.1.77

Application

Application Comment Organism
medicine mutations in the PCMT1 gene are associated with premature ovarian failure Homo sapiens

General Stability

General Stability Organism
the Ile isoform of PCMT is more stable, but the Val isoform has a 30% higher affinity for protein substrates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
PCMT1
-
 Homo sapiens
protein L-isoaspartate (D-aspartate) O-methyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PCMT1 repairs proteins that have been damaged by deamidation of asparagine or isomerization of aspartate, resulting in the spontaneous generation of L-isoaspartyl residues within peptides and proteins during aging Homo sapiens