EC Number   |
Natural Substrates |
|---|
   3.4.23.46 | amyloid precursor protein + H2O |
cleavage by beta-secretase at the N-terminus of the Abeta domain produces a fragment known as soluble beta-amyloid precursor protein and the remaining cell membrane spanning fragment of amyloid precursor protein (C99) |
| 3.4.23.46 | amyloid precursor protein-DELTANL + H2O |
the Swedish familial mutation in APP (DELTANL) enhances beta-secretase cleavage |
| 3.4.23.46 | amyloid-beta precursor protein + H2O |
- |
| 3.4.23.46 | amyloid-beta precursor protein + H2O |
beta-secretase first cleaves the ectodomain of amyloid-beta precursor protein to generate a membrane-bound fragment |
| 3.4.23.46 | amyloid-like protein 1 + H2O |
- |
| 3.4.23.46 | basigin + H2O |
- |
| 3.4.23.46 | beta subunit of voltage-gated sodium channel + H2O |
- |
| 3.4.23.46 | beta-amyloid precursor protein + H2O |
- |
| 3.4.23.46 | beta-amyloid precursor protein + H2O |
the loss of Niemann-Pick type C1 increases beta-secretase cleavage of beta-amyloid precursor protein |
| 3.4.23.46 | beta-secretase 1 + H2O |
- |
