3.4.23.46 amyloid -like PROTEIN 2 + H2O - 3.4.23.46 amyloid beta-precursor protein + H2O - 3.4.23.46 amyloid beta-precursor protein + H2O BACE1 and the amyloid beta-precursor protein processing pathway are critical for cognitive, emotional and synaptic functions 3.4.23.46 amyloid pbeta A4 protein + H2O - 3.4.23.46 amyloid precursor protein + H2O - 3.4.23.46 amyloid precursor protein + H2O first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease 3.4.23.46 amyloid precursor protein + H2O amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99) 3.4.23.46 amyloid precursor protein + H2O BACE1 cleaves amyloid precursor protein at the beta-site 3.4.23.46 amyloid precursor protein + H2O BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99 3.4.23.46 amyloid precursor protein + H2O beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein 3.4.23.46 amyloid precursor protein + H2O cleavage by beta-secretase at the N-terminus of the Abeta domain produces a fragment known as soluble beta-amyloid precursor protein and the remaining cell membrane spanning fragment of amyloid precursor protein (C99) 3.4.23.46 amyloid precursor protein-DELTANL + H2O the Swedish familial mutation in APP (DELTANL) enhances beta-secretase cleavage 3.4.23.46 amyloid-beta precursor protein + H2O - 3.4.23.46 amyloid-beta precursor protein + H2O beta-secretase first cleaves the ectodomain of amyloid-beta precursor protein to generate a membrane-bound fragment 3.4.23.46 amyloid-like protein 1 + H2O - 3.4.23.46 basigin + H2O - 3.4.23.46 beta subunit of voltage-gated sodium channel + H2O - 3.4.23.46 beta-amyloid precursor protein + H2O - 3.4.23.46 beta-amyloid precursor protein + H2O the loss of Niemann-Pick type C1 increases beta-secretase cleavage of beta-amyloid precursor protein 3.4.23.46 beta-secretase 1 + H2O - 3.4.23.46 beta2 subunit of voltage-gated sodium channel + H2O - 3.4.23.46 BMP and activin membrane-bound inhibitor homolog + H2O - 3.4.23.46 cache domain containing 1 + H2O - 3.4.23.46 carboxypeptidase D + H2O - 3.4.23.46 cation-independent mannose-6-phosphate receptor + H2O - 3.4.23.46 CD166 antigen + H2O - 3.4.23.46 CD276 antigen + H2O - 3.4.23.46 CD44 + H2O - 3.4.23.46 chondroitin sulfate proteoglycan 4 + H2O - 3.4.23.46 contactin-1 + H2O - 3.4.23.46 cysteine-rich motor neuron 1 protein + H2O - 3.4.23.46 desmoglein 2 + H2O - 3.4.23.46 disintegrin and metalloproteinase domain-containing protein 10 + H2O - 3.4.23.46 E-cadherin + H2O - 3.4.23.46 ephrin type-A receptor 2 + H2O - 3.4.23.46 ephrin type-A receptor 4 + H2O - 3.4.23.46 ephrin type-A receptor 7 + H2O - 3.4.23.46 ephrin-A5 + H2O - 3.4.23.46 ErbB4 + H2O - 3.4.23.46 glypican-3 + H2O - 3.4.23.46 Golgi apparatus protein 1 + H2O - 3.4.23.46 Golgi phosphoprotein 4 + H2O - 3.4.23.46 hepatocyte growth factor receptor + H2O - 3.4.23.46 HLA class I histocompatibility antigen (combined) + H2O - 3.4.23.46 interleukin-6 receptor beta chain + H2O - 3.4.23.46 Jagged-1 + H2O - 3.4.23.46 Klotho protein + H2O - 3.4.23.46 Kunitz-type protease inhibitor 2 + H2O - 3.4.23.46 leucin-rich repeats and immunoglobulin-like domains protein 1 + H2O - 3.4.23.46 leucin-rich repeats and immunoglobulin-like domains protein 2 + H2O - 3.4.23.46 leucin-rich repeats and immunoglobulin-like domains protein 3 + H2O - 3.4.23.46 leucine-rich repeat-containing protein 33 + H2O - 3.4.23.46 low-density lipoprotein receptor-related protein 11 + H2O - 3.4.23.46 low-density lipoprotein receptor-related protein 4 + H2O - 3.4.23.46 membrane-bound prostaglandin E2 synthase-2 + H2O BACE-1 is involved in the cleavage of membrane-bound prostaglandin E2 synthase-2 in its N-terminal portion, which, in turn, enhances the generation of prostaglandin E2 3.4.23.46 additional information broad endopeptidase specificity, cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein 3.4.23.46 additional information cleaves at the beta-secretase site of Alzheimer's amyloid precursor protein 3.4.23.46 additional information BACE1 is required for myelination and correct bundling of axons by Schwann cell most likely via processing of type III neuregulin 1 3.4.23.46 additional information beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling 3.4.23.46 additional information caveolin 1 and flotillin 1 may modulate beta-secretase activity by interacting with BACE1 3.4.23.46 N-cadherin + H2O - 3.4.23.46 neogenin + H2O - 3.4.23.46 netrin receptor UNC5C + H2O - 3.4.23.46 neuronal cell adhesion molecule 1 + H2O - 3.4.23.46 neuronal cell adhesion molecule L1 + H2O - 3.4.23.46 Notch + H2O - 3.4.23.46 Notch protein + H2O - 3.4.23.46 Notch-1 + H2O - 3.4.23.46 peptidyl-glycine alpha-amidating monooxygenase + H2O - 3.4.23.46 plexin domain-containing protein 2 + H2O - 3.4.23.46 podocalyxin-like protein 1 + H2O - 3.4.23.46 poliovirus receptor type I + H2O - 3.4.23.46 protocadherin 21 + H2O - 3.4.23.46 protocadherin 7 + H2O - 3.4.23.46 protocadherin gamma A11 + H2O - 3.4.23.46 protocadherin gamma A5 + H2O - 3.4.23.46 protocadherin gamma A8 + H2O - 3.4.23.46 protocadherin gamma C3 + H2O - 3.4.23.46 protogenin + H2O - 3.4.23.46 receptor protein tyrosine kinase variant EPHB4V1 + H2O - 3.4.23.46 receptor-type tyrosin-protein phosphatase S + H2O - 3.4.23.46 rhodamine-EVNLDAEFK-quencher + H2O - 3.4.23.46 roundabout homolog 1 + H2O - 3.4.23.46 roundabout homolog 2 + H2O - 3.4.23.46 seizure 6-like protein 2 + H2O - 3.4.23.46 semaphorin-4B + H2O - 3.4.23.46 semaphorin-4C + H2O - 3.4.23.46 semaphorin-6A + H2O - 3.4.23.46 semaphorin-6D + H2O - 3.4.23.46 sidekick-1 + H2O - 3.4.23.46 sidekick-2 + H2O - 3.4.23.46 sortilin type I + H2O - 3.4.23.46 sortilin-related receptor type I + H2O - 3.4.23.46 Swedish mutation of amyloid precursor protein + H2O - 3.4.23.46 syndecan-4 + H2O - 3.4.23.46 T-cell immunomodulatory protein + H2O - 3.4.23.46 toll-like receptor 9 + H2O - 3.4.23.46 trans-Golgi network integral membrane protein 2 + H2O - 3.4.23.46 transmembrane protein 132A + H2O - 3.4.23.46 tumor necrosis factor receptor superfamily member 21 + H2O - 3.4.23.46 vesicular integral-membrane protein VIP36 + H2O -