EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
    1.11.1.8 | more |
in the perinodular normal tissue the enzyme is absent in the apical surface, enzyme from multinodular goiter is absent in the microvilli |
- |
658882 |
| 1.11.1.8 | nuclear envelope |
in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles. In cells from Hashimotos thyroiditis. In Graves disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive |
GO:0005635 AmiGO QuickGO |
658882 |
| 1.11.1.8 | nuclear envelope |
wild-type enzyme and mutant enzymes G614A, G1687T, 1808-13del, C2083, G2401A |
GO:0005635 AmiGO QuickGO |
659944 |
| 1.11.1.8 | plasma membrane |
- |
GO:0005886 AmiGO QuickGO |
725615, 726514 |
| 1.11.1.8 | plasma membrane |
mutant enzymes D574/L575del, G553C and G771R expressed to varying degree on the plasma membrane. Mutant R665W shows no cell surface localization |
GO:0005886 AmiGO QuickGO |
659944 |
| 1.11.1.8 | rough endoplasmic reticulum |
in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles. In cells from Hashimotos thyroiditis detected in scarce rough endoplasmic reticulum. In Graves disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive |
GO:0005791 AmiGO QuickGO |
658882 |
| 1.11.1.8 | vesicle |
in Graves' disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive, in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles |
GO:0031982 AmiGO QuickGO |
658882 |
