EC Number   |
Inhibitors |
Structure  |
|---|
   3.5.1.13 | more |
phosphatidylinositol-specific phospholipase C of Staphylococcus aureus or sodium deoxycholate-activated endogenous phospholipase C solubilizes serotonin-sensitive arylacylamidase , a loss of activity occurs which can be restored by externally added phosphatidylinositol |
 |
| 3.5.1.13 | more |
the aryl acylamidase activity is associated with acetylcholinesterase in chicken embryonic brain, and is much more sensitive to Alzheimer drugs, huperzine and donepezil, especially at younger developmental stages, than the esterase activity of the acetylcholinesterase, whereas inhibition of esterase activity is sensitive to tacrine and DFP |
|
| 3.5.1.13 | more |
no effect by EDTA, 8-hydroxyquinoline, and 2-mercaptoethanol |
|
| 3.5.1.13 | more |
by molecular docking studies the most favourable binding site of aryl acylamidase substrates and serotonin is identified as the side door of acetylcholinesterase. Propidium, a peripheral anionic site binder blocks the main door without affecting the side door, which explains its ineffectiveness in inhibiting aryl acylamidase |
|
| 3.5.1.13 | more |
gallamine selectively inhibits the esterase activity to 63.6% (0.1 mM) and 45.4% (0.5 mM), whereas the aryl acylamidase activity remains significantly unaltered in the presence of gallamine (0.1 mM: 105.2%. 0.5 mM: 107%) |
|
| 3.5.1.13 | Mn2+ |
- |
  |
| 3.5.1.13 | Zn2+ |
- |
|
| 3.5.1.13 | Zn2+ |
0.1 mM, 51% inhibition |
|
| 3.5.1.13 | Zn2+ |
inhibits 40.0% at 1 mM and 75.8% at 10 mM |
|
| 3.5.1.13 | Ca2+ |
inhibits 21.1% at 1 mM and 21.5% at 10 mM |
|
