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EC Number
Inhibitors
Commentary
Structure
2.4.1.152
1-ethynylnaphthalene
exhibits highly potent inhibitory effects against the FUT-VI mediated sialyl Lewis X synthesis
2.4.1.152
6-F-GDP-fucose
complete inhibition
2.4.1.152
Cu2+
-
2.4.1.152
Cu2+
reduced activity
2.4.1.152
deoxyfuconojirimycin
modest inhibitor, causes 21% inhibition, synergism: combined with GDP at their Ki levels results in 80% inhibition, combined with GMP causes 50.4% inhibition
2.4.1.152
diethyldicarbonate
-
2.4.1.152
diethyldicarbonate
IC50: 0.092. Preincubation at 23°C gives maximal inhibition, 75%, after 180 s. Preincubation at 13°C gives 55% inhibition after 3 min. Preincubation at 4°C results in only 35% inhibition
2.4.1.152
dithionitrobenzene
-
2.4.1.152
GDP
causes 22% inhibition
2.4.1.152
GDP
0.191 mM causes 50% inhibition in the scintillation proximity assay and 0.214 mM causes 50% inhibition in the Dowex assay
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