EC Number   |
Activating Compound |
Reference |
|---|
   5.6.2.2 | 1,4-benzoquinone |
a topoisomerase II poison in vivo and in vitro, enhances cleavage activity, inhibits ligation activity, at 0.025 mM, 1,4-hydroquinone has a higher inhibitory effect on ligation activity but a lower effect on cleavage activity compared to 1,4-benzoquinone |
661475 |
| 5.6.2.2 | 1,4-hydroquinone |
physiological precursor of 1,4-benzoquinone, a topoisomerase II poison, enhances cleavage activity, inhibits ligation activity, at 0.25 mM, alters the enzyme's cleavage site specificity, 1,4-hydroquinone has a higher inhibitory effect on ligation activity but a lower effect on cleavage activity compared to 1,4-benzoquinone |
661475 |
| 5.6.2.2 | 2-(2-chlorophenyl)benzo-1,4-quinone |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | 2-(3,5-dichlorophenyl)benzo-1,4-quinone |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | 2-(3-chlorophenyl)benzo-1,4-quinone |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | 2-(4-chlorophenyl)benzo-1,4-quinone |
enhances DNA cleavage by isoform IIalpha up to 7fold |
678134 |
| 5.6.2.2 | 3-(4-chlorophenyl)benzo-1,2-quinone |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | 4'-chlorobiphenyl-2,5-diol |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | 4-(4-chlorophenyl)benzo-1,2-quinone |
enhances DNA cleavage by isoform IIalpha |
678134 |
| 5.6.2.2 | adenosine 5'-O-(3-thiotriphosphate) |
nonhydrolyzable ATP analogue sustains production of positive supercoils, but to a lesser extent, suggesting that ATP hydrolysis is necessary for efficient activity |
679506 |
