Literature summary for 5.6.2.2 extracted from

Bender, R.P.; Lehmler, H.J.; Robertson, L.W.; Ludewig, G.; Osheroff, N.
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate (2006), Biochemistry, 45, 10140-10152.

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Activating Compound

Activating Compound	Comment	Organism	Structure
2-(2-chlorophenyl)benzo-1,4-quinone	enhances DNA cleavage by isoform IIalpha	Homo sapiens
2-(3,5-dichlorophenyl)benzo-1,4-quinone	enhances DNA cleavage by isoform IIalpha	Homo sapiens
2-(3-chlorophenyl)benzo-1,4-quinone	enhances DNA cleavage by isoform IIalpha	Homo sapiens
2-(4-chlorophenyl)benzo-1,4-quinone	enhances DNA cleavage by isoform IIalpha up to 7fold	Homo sapiens
3-(4-chlorophenyl)benzo-1,2-quinone	enhances DNA cleavage by isoform IIalpha	Homo sapiens
4'-chlorobiphenyl-2,5-diol	enhances DNA cleavage by isoform IIalpha	Homo sapiens
4-(4-chlorophenyl)benzo-1,2-quinone	enhances DNA cleavage by isoform IIalpha	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(2-chlorophenyl)benzo-1,4-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
2-(3,5-dichlorophenyl)benzo-1,4-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
2-(3-chlorophenyl)benzo-1,4-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
2-(4-chlorophenyl)benzo-1,4-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
3-(4-chlorophenyl)benzo-1,2-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
4'-chlorobiphenyl-2,5-diol	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens
4-(4-chlorophenyl)benzo-1,2-quinone	inhibits DNA religation by isoform IIalpha by blocking the N-terminal gate of the enzyme by cross-linking cross-linking its two protomer subunits	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform IIalpha	-

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Release 2023.1 (January 2023)