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Version 2014-12-22
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Details for Rhino-Deadlock-Cutoff Complex
Gene ontology ID
GO:1990469
Definition
Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation
Comment
An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153.
Synonyms
1. RDC complex
2. rhi-del-cuff complex
References
1. GOC: bhm
2. PMID 24906153
3. IntAct: EBI-9694217
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