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EC unknown
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms KSL12, LOC_Os02g36020 , Os02g0568700 , Rv3378c, more
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Rv3378c
-
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(-)-ent-copalyl diphosphate + H2O = ent-manool + diphosphate
(-)-ent-copalyl diphosphate + H2O = ent-manool + diphosphate
products of Mycobacterium tuberculosis gene product Rv3378c are 22% (-)-ent-copalol, 8% ent-13-epi-manool plus 42% ent-manool. Enzyme catalyzes the removal reaction of the diphosphate moiety, followed by addition of water to the generated cation
(-)-ent-copalyl diphosphate + H2O = ent-manool + diphosphate
products of Mycobacterium tuberculosis gene product Rv3378c are 22% (-)-ent-copalol, 8% ent-13-epi-manool plus 42% ent-manool. Enzyme catalyzes the removal reaction of the diphosphate moiety, followed by addition of water to the generated cation
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(-)-ent-copalyl diphosphate + H2O = ent-manool + diphosphate
-
-
-
-
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(-)-ent-copalyl diphosphate diphosphate-lyase (ent-manool-forming)
-
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(-)-ent-copalyl diphosphate + H2O
ent-manool + diphosphate
ent-copalyl diphosphate + H2O
ent-manool + diphosphate
Substrates: - Products: -
?
additional information
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Substrates: no substrate: geranylgeranyl diphosphate Products: -
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(-)-ent-copalyl diphosphate + H2O
ent-manool + diphosphate
Substrates: - Products: products of Mycobacterium tuberculosis gene product Rv3378c are 40% (+)-copalool, 12% manool, 15% 13-epi-manool
?
(-)-ent-copalyl diphosphate + H2O
ent-manool + diphosphate
Substrates: - Products: products of Mycobacterium tuberculosis gene product Rv3378c are 40% (+)-copalool, 12% manool, 15% 13-epi-manool
?
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Mg2+
essentially required
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putative
UniProt
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putative
UniProt
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-
UniProt
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-
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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evolution
functional KSL12 homologs exist in diverse wild species in the Oryzeae, i.e.Oryza nivara (Oryza rufipogon), Oryza coarctata, Oryza granulata, Leersia perrieri, and Leersia tisseranti. KSL12 homologs in O. granulata, L. perrieri, and L. tisseranti preferentially react with geranylgeranyl diphosphate rather than ent-CDP, resulting in geranyllinalool rather than ent-manool or ent-13-epi-manool as the main product
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A0A0N7KFI7_ORYSJ
514
0
58185
TrEMBL
-
TUBAT_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
296
0
34031
Swiss-Prot
other Location (Reliability: 2 )
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expression in Escherichia coli
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expression is inducible by stress
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Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T.
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
Org. Biomol. Chem.
9
2156-2165
2011
Mycobacterium tuberculosis (P9WJ61), Mycobacterium tuberculosis H37Rv (P9WJ61)
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Itoh, A.; Nakazato, S.; Wakabayashi, H.; Hamano, A.; Shenton, M.R.; Miyamoto, K.; Mitsuhashi, W.; Okada, K.; Toyomasu, T.
Functional kaurene-synthase-like diterpene synthases lacking a gamma domain are widely present in Oryza and related species
Biosci. Biotechnol. Biochem.
85
1945-1952
2021
Oryza sativa Japonica Group (A0A0N7KFI7)
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