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(symmetrical) Ap4A hydrolase
(symmetrical) dinucleoside tetraphosphatase
-
-
adenosine tetraphosphate phosphodiesterase
-
-
-
-
bis(5'-adenosyl) tetraphosphatase
-
-
-
-
bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
-
-
diadenosine 5',5'''-P1,P4-tetraphosphatase
-
-
-
-
diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
-
-
-
-
diadenosine polyphosphate hydrolase
-
-
-
-
Diadenosine tetraphosphatase
-
-
-
-
diadenosine tetraphosphate hydrolase
diadenosinetetraphosphatase (symmetrical)
-
-
-
-
dinucleosidetetraphosphatase (symmetrical)
-
-
-
-
phosphatase, bis(5'-nucleosyl) tetra- (symmetrical)
-
-
-
-
symmetrical Ap4A hydrolase
-
-
symmetrical diadenosine tetraphosphate hydrolase
-
-
-
-
(symmetrical) Ap4A hydrolase
-
-
(symmetrical) Ap4A hydrolase
-
-
APAH
-
diadenosine tetraphosphate hydrolase
-
-
-
-
diadenosine tetraphosphate hydrolase
-
-
diadenosine tetraphosphate hydrolase
-
-
-
MXAN_1509
-
MXAN_7163
-
PrpA
-
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3'-adenylated bis(5'-adenosyl) tetraphosphate + H2O
3'-adenylated ADP + ADP
-
hydrolysis of 3'-adenylated Ap3A
-
-
?
3'-adenylated bis(5'-guanosyl) tetraphosphate + H2O
3'-adenylated GDP + GDP
-
hydrolysis of 3'-adenylated Gp3G
-
-
?
A5'-P(S)PPP-5'A + H2O
ADP + ADPalphaS
-
-
-
?
adenosine 5'-P(1)-tetraphosphate-P(4)-5'''-cytidine + H2O
ADP + CDP
-
-
-
?
adenosine 5'-P(1)-triphosphate-P(3)-5''-cytidine + H2O
ADP + CMP + CDP + AMP
-
-
-
?
adenosine 5'-P(1)-triphosphate-P(3)-5''-guanosine + H2O
ADP + GMP
-
-
-
?
Ap4G + H2O
ADP + GDP
-
-
-
?
ApCF2ppCF2pA + H2O
?
-
at 0.2% the rate of P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
ADP + ATP
diadenosine tetraphosphate + H2O
2 adenosine diphosphate
Gp3C + H2O
CDP + GMP
-
-
-
?
Gp3G + H2O
guanosine 3'-diphosphate + guanosine 5'-phosphate
Gp5G + H2O
GDP + GTP
-
-
-
?
Gp6G + H2O
GDP + guanosine 5'-tetraphosphate
-
-
-
?
P1,P4-bis(5'-(2'-deoxy)adenosyl)tetraphosphate + H2O
2 dADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
2 ADP
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
P1,P4-bis(adenosyl)tetraphosphate + H2O
2 ADP
P1,P5-bis(adenosyl)pentaphosphate + H2O
ADP + ATP
P1,P6-bis(5'-adenosyl)hexaphosphate + H2O
ADP + ?
-
hydrolysis of Ap6A
-
-
?
P1,P6-di(adenosine-5')hexaphosphate + H2O
ADP + adenosine 5'-tetraphosphate
p4G + H2O
GDP + diphosphate
-
-
-
?
additional information
?
-
Ap3A + H2O
ADP + AMP
-
-
-
-
?
Ap3A + H2O
ADP + AMP
-
-
-
-
?
Ap3A + H2O
ADP + AMP
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
ADP + ATP
-
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
ADP + ATP
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
ADP + ATP
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
ADP + ATP
-
-
-
?
diadenosine tetraphosphate + H2O
2 adenosine diphosphate
-
-
-
-
?
diadenosine tetraphosphate + H2O
2 adenosine diphosphate
-
-
-
-
?
Gp3G + H2O
guanosine 3'-diphosphate + guanosine 5'-phosphate
-
-
-
-
?
Gp3G + H2O
guanosine 3'-diphosphate + guanosine 5'-phosphate
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
2 ADP
-
hydrolysis of Ap4A
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
2 ADP
-
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
ADP
-
hydrolysis of Ap4A
-
-
?
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
-
-
-
-
?
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
-
-
-
-
?
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
-
-
-
-
?
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
-
-
-
?
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O
GTP
-
-
-
-
?
P1,P4-bis(adenosyl)tetraphosphate + H2O
2 ADP
-
-
-
?
P1,P4-bis(adenosyl)tetraphosphate + H2O
2 ADP
-
in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, reaction of EC 3.6.1.17, whereas in the presence of Co2+, PrpA hydrolyzes Ap4A into two molecules of ADP
-
?
P1,P4-bis(adenosyl)tetraphosphate + H2O
2 ADP
-
-
-
?
P1,P4-bis(adenosyl)tetraphosphate + H2O
2 ADP
-
in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, reaction of EC 3.6.1.17, whereas in the presence of Co2+, PrpA hydrolyzes Ap4A into two molecules of ADP
-
?
P1,P5-bis(adenosyl)pentaphosphate + H2O
ADP + ATP
-
-
-
?
P1,P5-bis(adenosyl)pentaphosphate + H2O
ADP + ATP
-
-
-
?
P1,P6-di(adenosine-5')hexaphosphate + H2O
ADP + adenosine 5'-tetraphosphate
-
-
-
-
?
P1,P6-di(adenosine-5')hexaphosphate + H2O
ADP + adenosine 5'-tetraphosphate
-
-
-
?
P1,P6-di(adenosine-5')hexaphosphate + H2O
ADP + adenosine 5'-tetraphosphate
-
-
-
?
P1,P6-di(adenosine-5')hexaphosphate + H2O
ADP + adenosine 5'-tetraphosphate
-
-
-
?
additional information
?
-
-
hydrolase from Escherichia coli shows almost no cleavage of dinucleoside polyphosphate molecules modified in their ADP moieties
-
-
?
additional information
?
-
enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP
-
-
?
additional information
?
-
enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP
-
-
?
additional information
?
-
-
enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP
-
-
?
additional information
?
-
PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP
-
-
?
additional information
?
-
PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP
-
-
?
additional information
?
-
-
PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP
-
-
?
additional information
?
-
enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP
-
-
?
additional information
?
-
enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP
-
-
?
additional information
?
-
PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP
-
-
?
additional information
?
-
PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP
-
-
?
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Cd2+
-
0.002-0.005 mM, 3.5fold stimulation
Mg2+
-
weak stimulation in absence of other divalent metal ions, high synergistic stimulation in combination with Co2+ at its suboptimal concentrations
Ni2+
-
0.004-0.008 mM, 3.5fold stimulation
Ca2+
-
no effect
Ca2+
-
weak stimulation in absence of other divalent metal ions, high synergistic stimulation in combination with Co2+ at its suboptimal concentration
Co2+
-
2500fold stimulation
Co2+
-
0.1-0.5 mM, 100fold increase of activity
Co2+
-
symmetrical Ap4A hydrolase is Co2+-dependent
Co2+
about 50% of the activity with Mn2+. In the presence of Mn2+, PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17
Co2+
required for ApnA hydrolysis
Mn2+
-
0.2-0.5 mM, 8fold stimulation
Mn2+
-
900fold stimulation
Mn2+
best activator. In the presence of Mn2+, PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17
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1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
-
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
1,2,3-tri(adenosine-5'-O-phospho) glycerol
-
-
1,3-di(adenosine-5'-O-phospho) glycerol
-
-
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
-
-
1,3-di(adenosine-5'-O-phosphorothio) glycerol
-
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
1,4-di(adenosine-5'-O-phosphorothio) butanediol
-
-
1,4-di(adenosine-5'-O-phosphorothio) erythritol
-
-
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
-
-
A-5'-pCH2OpOCH2p-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
A-5'-pCH2OpOpOCH2p-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
A-5'-pOCH2pCH2Op-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
A-5'-pOCH2pOpCH2Op-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
A-5'-pOpCH2OpOp-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
A-5'-pOpOCH2pCH2OpOp-5'-A
-
no activity as inhibitor of Escherichia coli symmetrical Ap4A hydrolase
adenosine 5'-tetraphosphate
-
-
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
-
-
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
glycerol phosphate
20 mM, 33.4% residual activity; 20 mM, 46.1% residual activity
guanosine 5'-tetraphosphate
-
-
iodoacetic acid
10 mM, 58.8% residual activity
N-ethylmaleimide
1 mM, 62.6% residual activity; 1 mM, 73.8% residual activity
sodium orthovanadate
1 mM, 6.7% residual activity
tetra(adenosine-5'-O-phospho) pentaerythritol
-
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
-
-
tri(adenosine-5'-O-phosphorothio) glycerol
-
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
trisodium phosphate
20 mM, 24.8% residual activity; 20 mM, 6.2% residual activity
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
competitive with respect to Ap4A
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
-
Cu2+
-
-
Cu2+
-
no effect below 0.03 mM, inhibition above
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
competitive with respect to Ap4A
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
-
EDTA
5 mM, 13.2% residual activity; 5 mM, 2.8% residual activity
Fe2+
-
no effect below 0.03 mM, inhibition above
Fe2+
-
no effect below 0.03 mM, inhibition above
Fe2+
-
no effect below 0.03 mM, inhibition above
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
-
Zn2+
-
no effect below 0.03 mM, inhibition above
Zn2+
-
exposure prior to the assay
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0.005 - 0.037
P1,P4-bis(5'-adenosyl) tetraphosphate
0.0026
P1,P4-bis(5'-adenosyl)tetraphosphate
-
and 0.037, biphasic kinetics
0.14 - 0.86
P1,P4-bis(adenosyl)tetraphosphate
0.19 - 0.49
P1,P5-bis(adenosyl)pentaphosphate
0.014
P1,P6-bis(5'-adenosyl)hexaphosphate
-
reaction medium contains 0.1 mM CoCl2
0.005
P1,P4-bis(5'-adenosyl) tetraphosphate
-
pH 7.6, 30°C
0.012
P1,P4-bis(5'-adenosyl) tetraphosphate
-
with Mn2+
0.022
P1,P4-bis(5'-adenosyl) tetraphosphate
-
with Co2+
0.025
P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
0.025
P1,P4-bis(5'-adenosyl) tetraphosphate
-
pH 7.6, 30°C
0.037
P1,P4-bis(5'-adenosyl) tetraphosphate
-
and 0.0026, biphasic kinetics
0.037
P1,P4-bis(5'-adenosyl) tetraphosphate
-
reaction medium contains 0.1 mM CoCl2
0.14
P1,P4-bis(adenosyl)tetraphosphate
pH 8.0, 50°C, presence of 1 mM Mn2+
0.86
P1,P4-bis(adenosyl)tetraphosphate
pH 8.0, 50°C, presence of 1 mM Co2+
0.19
P1,P5-bis(adenosyl)pentaphosphate
pH 8.0, 50°C, presence of 1 mM Mn2+
0.49
P1,P5-bis(adenosyl)pentaphosphate
pH 8.0, 50°C, presence of 1 mM Co2+
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0.006
1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
-
pH 7.6, 30°C
0.0013 - 0.0029
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
4.08
1,2,3-tri(adenosine-5'-O-phospho) glycerol
-
pH 7.6, 30°C
0.215
1,3-di(adenosine-5'-O-phospho) glycerol
-
pH 7.6, 30°C
0.005
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
-
pH 7.6, 30°C
0.157
1,3-di(adenosine-5'-O-phosphorothio) glycerol
-
pH 7.6, 30°C
0.0014 - 0.0039
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
0.089
1,4-di(adenosine-5'-O-phosphorothio) butanediol
-
pH 7.6, 30°C
0.078
1,4-di(adenosine-5'-O-phosphorothio) erythritol
-
pH 7.6, 30°C
0.109
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
-
pH 7.6, 30°C
0.001
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
-
pH 7.6, 30°C
0.00002 - 0.00004
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
0.028
tetra(adenosine-5'-O-phospho) pentaerythritol
-
pH 7.6, 30°C
0.0014 - 0.0018
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
0.003
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
-
pH 7.6, 30°C
0.007
tri(adenosine-5'-O-phosphorothio) glycerol
-
pH 7.6, 30°C
0.00008 - 0.0017
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
0.0013
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
pH 7.6, 30°C
0.0029
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
pH 7.6, 30°C
0.0014
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
pH 7.6, 30°C
0.0039
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
pH 7.6, 30°C
0.00002
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
pH 7.6, 30°C
0.00004
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
pH 7.6, 30°C
0.0014
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
pH 7.6, 30°C
0.0018
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
pH 7.6, 30°C
0.00008
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
pH 7.6, 30°C
0.0017
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
pH 7.6, 30°C
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Guranowski, A.; Brown, P.; Ashton, P.A.; Blackburn, G.M.
Regiospecificity of the hydrolysis of diadenosine polyphosphates catalyzed by three specific pyrophosphohydrolases
Biochemistry
33
235-240
1994
Escherichia coli
brenda
Barnes, L.D.; Culver, C.A.
Isolation and characterization of diadenosine 5,5-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum
Biochemistry
21
6123-6128
1982
Physarum polycephalum
brenda
Garrison, P.N.; Robertson, G.M.; Culver, C.A.; Barnes, L.D.
Diadenosine 5,5-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum. Substrate specificity
Biochemistry
21
6129-6133
1982
Physarum polycephalum
brenda
Guranowski, A.; Jakubowski, H.; Holler, E.
Catabolism of diadenosine 5,5-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5,5-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12
J. Biol. Chem.
258
14784-14789
1983
Acidaminococcus fermentans, Escherichia coli, Pyrodictium occultum
brenda
Guranowski, A.; Biryukov, A.; Tarussova, N.B.; Khomutov, R.M.; Jakubowski, H.
Phosphonate analogues of diadenosine 5,5-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates
Biochemistry
26
3425-3429
1987
Escherichia coli
brenda
Taylor, G.E.; Blackburn, G.M.; Prescott, M.; McLennan, A.G.
Phosphonate analogs of bis(5'-adenosyl)tetraphosphate
Biochem. Soc. Trans.
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