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1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
2'-deoxyadenosine + H2O
?
3'-deoxyadenosine + H2O
?
5'-deoxyadenosine + H2O
?
5'-methylthioadenosine + H2O
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
S-adenosyl-L-homocysteine + H2O
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide + H2O
?
-
-
-
?
2'-deoxyadenosine + H2O
?
-
-
-
?
2'-deoxyadenosine + H2O
?
-
-
-
?
2'-deoxyadenosine + H2O
?
-
-
-
?
2'-deoxyadenosine + H2O
?
-
-
-
?
3'-deoxyadenosine + H2O
?
-
-
-
?
3'-deoxyadenosine + H2O
?
-
-
-
?
3'-deoxyadenosine + H2O
?
-
-
-
?
3'-deoxyadenosine + H2O
?
-
-
-
?
5'-deoxyadenosine + H2O
?
-
-
-
?
5'-deoxyadenosine + H2O
?
-
-
-
?
5'-deoxyadenosine + H2O
?
-
-
-
?
5'-deoxyadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
the enzyme is part of the futalosine pathway for menaquinone biosynthesis
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
6-amino-6-deoxyfutalosine i.e. 3-[3-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]propanoyl]benzoate
futalosine i.e. 3-[3-[(3S,4R)-3,4-dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl]propanoyl]benzoate
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
futalosine + NH3
-
-
-
?
adenosine + H2O
?
-
-
-
?
adenosine + H2O
?
-
-
-
?
adenosine + H2O
?
-
-
-
?
adenosine + H2O
?
-
-
-
?
AMP + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
?
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0.061
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
0.037
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.042
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.094 - 1
5'-methylthioadenosine
0.0009 - 0.008
6-amino-6-deoxyfutalosine
0.094
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.1 - 1
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.0009
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.0018
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.0034
6-amino-6-deoxyfutalosine
mutant enzyme R87A, at pH 7.5 and at 30°C
0.0048
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.006
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.008
6-amino-6-deoxyfutalosine
mutant enzyme R87M, at pH 7.5 and at 30°C
0.0083
adenosine
mutant enzyme R87A, at pH 7.5 and at 30°C
0.01
adenosine
mutant enzyme R87M, at pH 7.5 and at 30°C
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0.007
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
0.72
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.017
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.31 - 0.4
5'-methylthioadenosine
0.094 - 8.6
6-amino-6-deoxyfutalosine
0.31
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.4
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.094
6-amino-6-deoxyfutalosine
mutant enzyme R87A, at pH 7.5 and at 30°C
0.42
6-amino-6-deoxyfutalosine
mutant enzyme R87M, at pH 7.5 and at 30°C
1.2
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
3.8
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
6.8
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
8.6
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.106
adenosine
mutant enzyme R87A, at pH 7.5 and at 30°C
0.41
adenosine
mutant enzyme R87M, at pH 7.5 and at 30°C
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0.034 - 10
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
0.005 - 19
2'-deoxyadenosine
0.006 - 0.24
3'-deoxyadenosine
0.047 - 74
5'-deoxyadenosine
0.028 - 34
5'-methylthioadenosine
27 - 4800
6-amino-6-deoxyfutalosine
0.024 - 7
S-adenosyl-L-homocysteine
0.034
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
0.11
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
0.11
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
10
1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
wild type enzyme, at pH 7.5 and at 30°C
0.005
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.051
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
1.1
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
19
2'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.006
3'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.024
3'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.044
3'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.24
3'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.047
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.41
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
2.9
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
74
5'-deoxyadenosine
wild type enzyme, at pH 7.5 and at 30°C
0.028
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
2.8
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
4.3
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
34
5'-methylthioadenosine
wild type enzyme, at pH 7.5 and at 30°C
27
6-amino-6-deoxyfutalosine
mutant enzyme R87A, at pH 7.5 and at 30°C
53
6-amino-6-deoxyfutalosine
mutant enzyme R87M, at pH 7.5 and at 30°C
790
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
1100
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
1300
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
4800
6-amino-6-deoxyfutalosine
wild type enzyme, at pH 7.5 and at 30°C
0.011
adenosine
wild type enzyme, at pH 7.5 and at 30°C
0.02
adenosine
wild type enzyme, at pH 7.5 and at 30°C
13
adenosine
mutant enzyme R87A, at pH 7.5 and at 30°C
18
adenosine
wild type enzyme, at pH 7.5 and at 30°C
22
adenosine
wild type enzyme, at pH 7.5 and at 30°C
41
adenosine
mutant enzyme R87M, at pH 7.5 and at 30°C
0.003
AMP
wild type enzyme, at pH 7.5 and at 30°C
0.021
AMP
wild type enzyme, at pH 7.5 and at 30°C
0.032
AMP
wild type enzyme, at pH 7.5 and at 30°C
0.045
AMP
wild type enzyme, at pH 7.5 and at 30°C
0.024
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.5 and at 30°C
0.079
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.5 and at 30°C
0.31
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.5 and at 30°C
7
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.5 and at 30°C
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Arakawa, C.; Kuratsu, M.; Furihata, K.; Hiratsuka, T.; Itoh, N.; Seto, H.; Dairi, T.
Diversity of the early step of the futalosine pathway
Antimicrob. Agents Chemother.
55
913-916
2011
Acidothermus cellulolyticus (A0LRH8)
brenda
Goble, A.M.; Toro, R.; Li, X.; Ornelas, A.; Fan, H.; Eswaramoorthy, S.; Patskovsky, Y.; Hillerich, B.; Seidel, R.; Sali, A.; Shoichet, B.K.; Almo, S.C.; Swaminathan, S.; Tanner, M.E.; Raushel, F.M.
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes
Biochemistry
52
6525-6536
2013
Acidothermus cellulolyticus (A0LRH8), Nitratiruptor sp. SB155-2 (A6Q234), Streptomyces avermitilis (Q82K09), Deinococcus radiodurans (Q9RW45), Acidothermus cellulolyticus 11B (A0LRH8), Acidothermus cellulolyticus 11B, Streptomyces avermitilis MA-4680 (Q82K09), Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 (Q9RW45)
brenda
Dairi, T.
Menaquinone biosyntheses in microorganisms
Methods Enzymol.
515
107-122
2012
Acidothermus cellulolyticus (A0LRH8), Streptomyces coelicolor (O86737), Streptomyces coelicolor A3(2) (O86737)
brenda