show all | hide all No of entries

Information on EC 3.2.1.97 - endo-alpha-N-acetylgalactosaminidase

for references in articles please use BRENDA:EC3.2.1.97
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme catalyses the liberation of Gal-(1->3)-beta-GalNAc alpha-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from the bacterium Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. The enzymes from the bacteria Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. they can also release the core 2 trisaccharide Gal-(1->3)-beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-(1->3)-beta-GalNAc) [1,2]. The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan.
Specify your search results
Select one or more organisms in this record: ?
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
acetylgalactosaminidase, endo-alpha, D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetylgalactosaminohydrolase, endo GalNAc-ase S, endo-alpha-acetylgalactosaminidase, endo-alpha-GalNAc-ase, endo-alpha-N-acetylgalactosaminidase, endo-alpha-N-acetylgalactosaminidase S, endo-beta-N-acetylgalactosaminidase, endo-EF, endo-GalNAc-ase S, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-[glycoprotein]-L-serine/L-threonine + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + [glycoprotein]-L-serine/L-threonine
show the reaction diagram
-
-
-
-
Select items on the left to see more content.