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EC Tree
IUBMB Comments The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).
The enzyme appears in viruses and cellular organisms
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2,3-didehydroadipoyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-didehydrosuberoyl-CoA
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2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration)
The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).
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CoA + 3-oxo-5,6-didehydrosuberoyl-CoA
2,3-didehydroadipoyl-CoA + acetyl-CoA
additional information
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CoA + 3-oxo-5,6-didehydrosuberoyl-CoA
2,3-didehydroadipoyl-CoA + acetyl-CoA
transforms the beta-keto C8 intermediate of phenylacetate catabolic pathway with CoA to the C6 intermediate dehydroadipyl-CoA and acetyl-CoA
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CoA + 3-oxo-5,6-didehydrosuberoyl-CoA
2,3-didehydroadipoyl-CoA + acetyl-CoA
transforms the beta-keto C8 intermediate of phenylacetate catabolic pathway with CoA to the C6 intermediate dehydroadipyl-CoA and acetyl-CoA
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additional information
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enzyme additionally catalyzes the last step of the pathway, in which 3-oxoadipyl-CoA similarly is cleaved to acetyl-CoA and succinyl-CoA, reaction of EC 2.3.1.174
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additional information
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enzyme additionally catalyzes the last step of the pathway, in which 3-oxoadipyl-CoA similarly is cleaved to acetyl-CoA and succinyl-CoA, reaction of EC 2.3.1.174
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putative
UniProt
brenda
putative
UniProt
brenda
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PAAJ_ECOLI
Escherichia coli (strain K12)
401
0
42277
Swiss-Prot
-
A0A177HLF7_9ACTN
975
0
102650
TrEMBL
-
A0A7G2D2I7_9MICO
383
0
40434
TrEMBL
-
A0A653ZPT0_9ACTN
408
0
41869
TrEMBL
-
A0A653VXV7_9MICO
388
0
41253
TrEMBL
-
A0A7X0EI60_9BACI
402
0
43186
TrEMBL
-
A0A7W4SCC8_ENTAG
401
0
42246
TrEMBL
-
A0A1J5QV39_9ZZZZ
394
0
41485
TrEMBL
Mitochondrion (Reliability: 3 )
A0A7V9Z701_9BACI
401
0
43134
TrEMBL
-
A0A1F2PTF6_RHOER
403
0
42583
TrEMBL
-
A0A0H2LQD3_VARPD
378
0
39742
TrEMBL
-
A0A375IM51_9BURK
383
0
40275
TrEMBL
-
A0A1K0J3D7_CUPNE
383
0
40454
TrEMBL
-
A0A1I9Z0E4_9NOCA
388
0
40855
TrEMBL
-
A0A653PXA0_9MICO
401
0
42492
TrEMBL
-
A0A375GEQ9_9BURK
383
0
40253
TrEMBL
-
A0A375GE37_9BURK
383
0
40406
TrEMBL
-
A0A0H2M4T5_VARPD
390
0
40925
TrEMBL
-
A0A177HRP2_9ACTN
406
0
43517
TrEMBL
-
A0A0E3VC75_RHOER
406
0
42648
TrEMBL
-
A0A7W6ARR2_9BACI
401
0
43236
TrEMBL
-
A0A1J5QIK6_9ZZZZ
391
1
40958
TrEMBL
Mitochondrion (Reliability: 3 )
A0A1J5QJK0_9ZZZZ
168
0
17370
TrEMBL
Secretory Pathway (Reliability: 5 )
A0A7X0HMP5_9BACI
401
0
43006
TrEMBL
-
A0A1J5P3Z4_9ZZZZ
239
0
24330
TrEMBL
other Location (Reliability: 1 )
A0A0K2YK39_9NOCA
397
0
40978
TrEMBL
-
A0A132BXZ1_9RHOB
394
0
41615
TrEMBL
-
A0A653TWW2_9MICC
406
0
42865
TrEMBL
-
A0A1F2PSM6_RHOER
400
0
42470
TrEMBL
-
A0A7W8CMR3_9MYCO
412
0
42982
TrEMBL
-
A0A653PBK5_9MICO
408
0
43453
TrEMBL
-
A0A177HUB3_9ACTN
178
0
17922
TrEMBL
-
A0A1F2PT37_RHOER
388
0
40244
TrEMBL
-
Q845J8_9PSED
401
0
41821
TrEMBL
-
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Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G.
Bacterial phenylalanine and phenylacetate catabolic pathway revealed
Proc. Natl. Acad. Sci. USA
107
14390-14395
2010
Pseudomonas sp. (Q845J8), Pseudomonas sp. Y2 (Q845J8)
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