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Information on EC 2.3.1.223 - 3-oxo-5,6-didehydrosuberyl-CoA thiolase

for references in articles please use BRENDA:EC2.3.1.223

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EC Tree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.223 3-oxo-5,6-didehydrosuberyl-CoA thiolase

IUBMB Comments

The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).

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The expected taxonomic range for this enzyme is: Pseudomonas

Reaction Schemes

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2,3-didehydroadipoyl-CoA

acetyl-CoA

CoA

3-oxo-5,6-didehydrosuberoyl-CoA

Synonyms

PaaJ,

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

PaaJ

gene name

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2,3-didehydroadipoyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-didehydrosuberoyl-CoA

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PATHWAY SOURCE

PATHWAYS

BRENDA

phenylacetate degradation (aerobic)

KEGG

Microbial metabolism in diverse environments, Phenylalanine metabolism

MetaCyc

phenylacetate degradation I (aerobic)

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SYSTEMATIC NAME

IUBMB Comments

2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration)

The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

CoA + 3-oxo-5,6-didehydrosuberoyl-CoA

2,3-didehydroadipoyl-CoA + acetyl-CoA

2 entries

additional information

2 entries

CoA + 3-oxo-5,6-didehydrosuberoyl-CoA

2,3-didehydroadipoyl-CoA + acetyl-CoA

Pseudomonas sp.

Q845J3

transforms the beta-keto C8 intermediate of phenylacetate catabolic pathway with CoA to the C6 intermediate dehydroadipyl-CoA and acetyl-CoA

716755

CoA + 3-oxo-5,6-didehydrosuberoyl-CoA

2,3-didehydroadipoyl-CoA + acetyl-CoA

Pseudomonas sp. Y2

Q845J3

transforms the beta-keto C8 intermediate of phenylacetate catabolic pathway with CoA to the C6 intermediate dehydroadipyl-CoA and acetyl-CoA

716755

additional information

Pseudomonas sp.

Q845J3

enzyme additionally catalyzes the last step of the pathway, in which 3-oxoadipyl-CoA similarly is cleaved to acetyl-CoA and succinyl-CoA, reaction of EC 2.3.1.174

716755

additional information

Pseudomonas sp. Y2

Q845J3

enzyme additionally catalyzes the last step of the pathway, in which 3-oxoadipyl-CoA similarly is cleaved to acetyl-CoA and succinyl-CoA, reaction of EC 2.3.1.174

716755