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IUBMB Comments The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 EC 2.1.1.195 , cobalt-precorrin-5B (C1)-methyltransferase, for the C 1
Synonyms
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precorrin-6X synthase (deacetylating)
CobF
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precorrin-6X synthase (deacetylating)
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precorrin-6X synthase (deacetylating)
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precorrin-6X synthase (deacetylating)
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S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively
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S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
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methyl group transfer
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methyl group transfer
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MetaCyc
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
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S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)
The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 of precorrin-5, and its deacetylation, forming precorrin-6A. See EC 2.1.1.195, cobalt-precorrin-5B (C1)-methyltransferase, for the C1-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway.
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6x + acetate
S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: -
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: enzyme is involved in synthesis of hydrogenobyrinic acid
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: -
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6x + acetate
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Substrates: -
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6x + acetate
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Substrates: -
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: -
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: enzyme is involved in synthesis of hydrogenobyrinic acid
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
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S-adenosyl-L-methionine + precorrin-5 + H2O
S-adenosyl-L-homocysteine + precorrin-6A + acetate
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Substrates: -
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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28944
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2 * 28944, calculation from nucleotide sequence
30000
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2 * 30000, SDS-PAGE
31000
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x * 31000, SDS-PAGE
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x * 31000, SDS-PAGE
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x * 31000, SDS-PAGE
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dimer
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2 * 28944, calculation from nucleotide sequence
dimer
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2 * 30000, SDS-PAGE
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expression in Escherichia coli
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Roessner, C.A.; Spencer, J.B.; Ozaki, S.; Min, C.; Atshaves, B.P.; Nayar, P.; Anousis, N.; Stolowich, N.J.; Holderman, M.T.; Scott, A.I.
Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes
Protein Expr. Purif.
6
155-163
1995
Pseudomonas denitrificans (nom. rej.)
brenda
Debussche, L.; Thibaut, D.; Cameron, B.; Crouzet, J.; Blanche, F.
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans
J. Bacteriol.
175
7430-7440
1993
Pseudomonas denitrificans (nom. rej.)
brenda
Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.
The biosynthesis of adenosylcobalamin (vitamin B12)
Nat. Prod. Rep.
19
390-412
2002
Pseudomonas denitrificans (nom. rej.)
brenda
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