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Information on EC 1.7.1.9 - nitroquinoline-N-oxide reductase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.7.1.9
-
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RECOMMENDED NAME
GeneOntology No.
nitroquinoline-N-oxide reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
4-(hydroxyamino)quinoline N-oxide may be the active intermediate essential in the carcinogenic process of 4-nitroquinoline N-oxide
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4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
37256-35-2
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
strong preference for NADH
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
strong preference for NADH
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
-
-
?
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
NADH is preferred, 15% activity with NADPH
-
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.4
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.7.1.9)
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